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36 results

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Comparison of the efficacy between NAC and metformin in treating PCOS patients: a meta-analysis.
Song Y, Wang H, Huang H, Zhu Z. Song Y, et al. Gynecol Endocrinol. 2020 Mar;36(3):204-210. doi: 10.1080/09513590.2019.1689553. Epub 2019 Nov 21. Gynecol Endocrinol. 2020. PMID: 31749393
Our aim is to evaluate the clinical effectiveness and safety by comparing N-acetyl-cysteine (NAC) with metformin administrated by polycystic ovary syndrome (PCOS) patients. ...In conclusions, NAC may be considered as an alternative supplement to metformin, bu …
Our aim is to evaluate the clinical effectiveness and safety by comparing N-acetyl-cysteine (NAC) with metformin administrated by pol …
Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome.
Hu M, Zhang Y, Ma S, Li J, Wang X, Liang M, Sferruzzi-Perri AN, Wu X, Ma H, Brännström M, Shao LR, Billig H. Hu M, et al. Mol Hum Reprod. 2021 Nov 27;27(12):gaab067. doi: 10.1093/molehr/gaab067. Mol Hum Reprod. 2021. PMID: 34850077
The mechanisms that link hyperandrogenism and insulin (INS) resistance (HAIR) to the increased miscarriage rate in women with polycystic ovary syndrome (PCOS) remain elusive. Previous studies demonstrate that increased uterine and placental ferroptosis is associated with o …
The mechanisms that link hyperandrogenism and insulin (INS) resistance (HAIR) to the increased miscarriage rate in women with polycystic ova …
Metformin inhibits ovarian granular cell pyroptosis through the miR-670-3p/NOX2/ROS pathway.
Zhou LH, Zou H, Hao JY, Huang Y, Zhang JN, Xu XH, Li J. Zhou LH, et al. Aging (Albany NY). 2023 May 25;15(10):4429-4443. doi: 10.18632/aging.204745. Epub 2023 May 25. Aging (Albany NY). 2023. PMID: 37244286 Free PMC article.
Recent studies have demonstrated that ovarian granular cells (OGCs) pyroptosis is present in the ovaries of polycystic ovary syndrome (PCOS) mice and that NLRP3 activation destroys follicular functions. Metformin has been shown to protect against PCOS by reducing in …
Recent studies have demonstrated that ovarian granular cells (OGCs) pyroptosis is present in the ovaries of polycystic ovary syndrome (PC …
Hyperandrogenism and insulin resistance-induced fetal loss: evidence for placental mitochondrial abnormalities and elevated reactive oxygen species production in pregnant rats that mimic the clinical features of polycystic ovary syndrome.
Zhang Y, Zhao W, Xu H, Hu M, Guo X, Jia W, Liu G, Li J, Cui P, Lager S, Sferruzzi-Perri AN, Li W, Wu XK, Han Y, Brännström M, Shao LR, Billig H. Zhang Y, et al. J Physiol. 2019 Aug;597(15):3927-3950. doi: 10.1113/JP277879. Epub 2019 Jul 3. J Physiol. 2019. PMID: 31206177 Free article.
KEY POINTS: Women with polycystic ovary syndrome (PCOS) commonly suffer from miscarriage, but the underlying mechanisms remain unknown. ...However, NAC administration resulted in fetal loss in normal pregnant rats, most likely due to PCOS-like endocrine abnor …
KEY POINTS: Women with polycystic ovary syndrome (PCOS) commonly suffer from miscarriage, but the underlying mechanisms remain unknow …
Alpha lipoic acid in obstetrics and gynecology.
Di Tucci C, Di Feliciantonio M, Vena F, Capone C, Schiavi MC, Pietrangeli D, Muzii L, Benedetti Panici P. Di Tucci C, et al. Gynecol Endocrinol. 2018 Sep;34(9):729-733. doi: 10.1080/09513590.2018.1462320. Epub 2018 May 4. Gynecol Endocrinol. 2018. PMID: 29726290 Review.
ALA reduces oxidative stress and insulin resistance in women with polycystic ovary syndrome (PCOS). The association of N-acetyl cysteine (NAC), alpha-lipoic acid (ALA), and bromelain (Br) is used for prevention and treatment of endometriosis. ...
ALA reduces oxidative stress and insulin resistance in women with polycystic ovary syndrome (PCOS). The association of N-acetyl cyste …
The effects of N-acetylcysteine supplement on metabolic parameters in women with polycystic ovary syndrome: a systematic review and meta-analysis.
Liu J, Su H, Jin X, Wang L, Huang J. Liu J, et al. Front Nutr. 2023 Sep 29;10:1209614. doi: 10.3389/fnut.2023.1209614. eCollection 2023. Front Nutr. 2023. PMID: 37841396 Free PMC article.
However, NAC reduced HDL levels in women with PCOS compared with metformin (SMD: -0.14, 95% CI: -0.42 to 0.14). CONCLUSION: This study suggests that NAC is effective in improving metabolic parameters in PCOS and may be a promising nutritional supplemen …
However, NAC reduced HDL levels in women with PCOS compared with metformin (SMD: -0.14, 95% CI: -0.42 to 0.14). CONCLUSION: Th …
The effects of N-acetylcysteine on ovulation and sex hormones profile in women with polycystic ovary syndrome: a systematic review and meta-analysis.
Shahveghar Asl Z, Parastouei K, Eskandari E. Shahveghar Asl Z, et al. Br J Nutr. 2023 Jul 28;130(2):202-210. doi: 10.1017/S0007114522003270. Epub 2023 Jan 4. Br J Nutr. 2023. PMID: 36597797 Review.
Clinical trials on the effects of N-acetylcysteine (NAC) supplementation on ovulation and sex hormones profile in women with PCOS have been controversial. ...Overall, NAC supplementation might be effective in the improvement of reproductive system function in …
Clinical trials on the effects of N-acetylcysteine (NAC) supplementation on ovulation and sex hormones profile in women with PCOS …
Effects of N-acetylcysteine and metformin treatment on the stereopathological characteristics of uterus and ovary.
Rafiee B, Karbalay-Doust S, Tabei SMB, Azarpira N, Alaee S, Lohrasbi P, Bahmanpour S. Rafiee B, et al. Eur J Transl Myol. 2022 May 9;32(2):10409. doi: 10.4081/ejtm.2022.10409. Eur J Transl Myol. 2022. PMID: 35535444 Free PMC article.
In this study, the stereo-pathological effect of metformin and N-acetyl cysteine is evaluated on the uterus and ovary of polycystic ovary syndrome (PCOS) mice. 96 mature females (8-weekold, weight of 20-30 gr) BALB/c mice were classified into 6 groups including the control …
In this study, the stereo-pathological effect of metformin and N-acetyl cysteine is evaluated on the uterus and ovary of polycystic ovary sy …
N-acetylcysteine for polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled clinical trials.
Thakker D, Raval A, Patel I, Walia R. Thakker D, et al. Obstet Gynecol Int. 2015;2015:817849. doi: 10.1155/2015/817849. Epub 2015 Jan 8. Obstet Gynecol Int. 2015. PMID: 25653680 Free PMC article. Review.
Objective. To review the benefits and harms of N-acetylcysteine (NAC) in women with polycystic ovary syndrome (PCOS). Method. Literature search was conducted using the bibliographic databases, MEDLINE (Ovid), CINAHL, EMBASE, Scopus, PsyInfo, and PROQUEST (from incep …
Objective. To review the benefits and harms of N-acetylcysteine (NAC) in women with polycystic ovary syndrome (PCOS). Method. …
N-acetyl-cysteine as adjuvant therapy in female infertility: a systematic review and meta-analysis.
Devi N, Boya C, Chhabra M, Bansal D. Devi N, et al. J Basic Clin Physiol Pharmacol. 2020 Nov 19;32(5):899-910. doi: 10.1515/jbcpp-2020-0107. J Basic Clin Physiol Pharmacol. 2020. PMID: 34592079 Review.
NAC was found less efficacious and safe than metformin in all outcomes. Overall, NAC showed statistically insignificant (OR=0.98-2.47). OUTLOOK: NAC can be an effective adjuvant in PCOS related and unexplained female infertility. ...
NAC was found less efficacious and safe than metformin in all outcomes. Overall, NAC showed statistically insignificant (OR=0. …
36 results