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Therapy-Induced Senescence Drives Bone Loss.
Yao Z, Murali B, Ren Q, Luo X, Faget DV, Cole T, Ricci B, Thotala D, Monahan J, van Deursen JM, Baker D, Faccio R, Schwarz JK, Stewart SA. Yao Z, et al. Among authors: van deursen jm. Cancer Res. 2020 Mar 1;80(5):1171-1182. doi: 10.1158/0008-5472.CAN-19-2348. Epub 2020 Jan 13. Cancer Res. 2020. PMID: 31932453 Free PMC article.
While great strides have been made to ameliorate the acute toxicities induced by chemotherapy, long-term comorbidities including bone loss remain a significant problem. ...
While great strides have been made to ameliorate the acute toxicities induced by chemotherapy, long-term comorbidities including bone …
Aneuploidy in Cancer and Aging.
Naylor RM, van Deursen JM. Naylor RM, et al. Among authors: van deursen jm. Annu Rev Genet. 2016 Nov 23;50:45-66. doi: 10.1146/annurev-genet-120215-035303. Annu Rev Genet. 2016. PMID: 27893964 Free PMC article. Review.
With this review, we aim to expand our understanding of the role of CIN in cancer and aging with the long-term objective of harnessing this information for the advancement of patient care....
With this review, we aim to expand our understanding of the role of CIN in cancer and aging with the long-term objective of harnessin …
Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.
Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK. Schafer MJ, et al. Among authors: van deursen jm. Diabetes. 2016 Jun;65(6):1606-15. doi: 10.2337/db15-0291. Epub 2016 Mar 16. Diabetes. 2016. PMID: 26983960 Free PMC article.
We show that exercise prevents the accumulation of senescent cells and the expression of the SASP while nullifying the damaging effects of the FFD on parameters of health. We also demonstrate that exercise initiated after long-term FFD feeding reduces senescent phenotype m …
We show that exercise prevents the accumulation of senescent cells and the expression of the SASP while nullifying the damaging effects of t …
CREB binding protein is required for both short-term and long-term memory formation.
Chen G, Zou X, Watanabe H, van Deursen JM, Shen J. Chen G, et al. Among authors: van deursen jm. J Neurosci. 2010 Sep 29;30(39):13066-77. doi: 10.1523/JNEUROSCI.2378-10.2010. J Neurosci. 2010. PMID: 20881124 Free PMC article.
CBP cKO mice exhibited robust impairment in the formation of spatial, associative, and object-recognition memory. In addition to impaired long-term memory, CBP cKO mice also displayed deficits in short-term associative and object-recognition memory. ...Collectively, …
CBP cKO mice exhibited robust impairment in the formation of spatial, associative, and object-recognition memory. In addition to impaired lo …