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Visual stimulation by extensive visual media consumption can be beneficial for motor learning.
Nuernberger M, Finke K, Nuernberger L, Ruiz-Rizzo AL, Gaser C, Klingner C, Witte OW, Brodoehl S. Nuernberger M, et al. Among authors: witte ow. Sci Rep. 2023 Dec 12;13(1):22056. doi: 10.1038/s41598-023-49415-4. Sci Rep. 2023. PMID: 38086999 Free PMC article. Clinical Trial.

We found that the intervention group performed significantly better in the motor learning task (+ 8.21% (95%-CI[12.04, 4.31], t(70) = 4.23, p < 0.001) while showing an increased capacity of visual short-term memory (+ 0.254, t(58) = - 3.19, p = 0.002) and increased conn

We found that the intervention group performed significantly better in the motor learning task (+ 8.21% (95%-CI[12.04, 4.31], t(70) = 4.23, …
Restoring Age-Related Cognitive Decline through Environmental Enrichment: A Transcriptomic Approach.
Schmidt S, Haase M, Best L, Groth M, Lindner J, Witte OW, Kaleta C, Frahm C. Schmidt S, et al. Among authors: witte ow. Cells. 2022 Nov 30;11(23):3864. doi: 10.3390/cells11233864. Cells. 2022. PMID: 36497123 Free PMC article.
Our analyses showed that late-onset EE was able to restore deficits in spatial learning and short-term memory in 24-month-old mice. These positive cognitive effects were reflected by specific changes in the hippocampal transcriptome, where late-onset EE affected transcript …
Our analyses showed that late-onset EE was able to restore deficits in spatial learning and short-term memory in 24-month-old mice. T …
Shaping the Sensory-Motor Network by Short-Term Unresolvable Sensory-Motor Mismatch.
Klingner CM, Kattlun F, Krolopp L, Jochmann E, Volk GF, Brodoehl S, Guntinas-Lichius O, Witte OW, Dobel C. Klingner CM, et al. Among authors: witte ow. Front Neurol. 2022 Jan 12;12:793662. doi: 10.3389/fneur.2021.793662. eCollection 2021. Front Neurol. 2022. PMID: 35095737 Free PMC article.
However, in contrast to long-term mismatch, we did not find the involvement of the cerebral motor cortex. The lack of the involvement of the motor cortex can be interpreted both as an effect of time and also as an effect of the lack of a reduction in the motor error. The s …
However, in contrast to long-term mismatch, we did not find the involvement of the cerebral motor cortex. The lack of the involvement …
Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging.
Barth E, Srivastava A, Wengerodt D, Stojiljkovic M, Axer H, Witte OW, Kretz A, Marz M. Barth E, et al. Among authors: witte ow. Aging (Albany NY). 2021 Dec 19;13(24):25694-25716. doi: 10.18632/aging.203788. Epub 2021 Dec 19. Aging (Albany NY). 2021. PMID: 34923482 Free PMC article.
Our results illustrate how the circadian system and aging might influence each other in various tissues over a long lifespan and conceptually complement previous studies tracking short-term diurnal and nocturnal gene expression oscillations....
Our results illustrate how the circadian system and aging might influence each other in various tissues over a long lifespan and conceptuall …
Poststroke dendritic arbor regrowth requires the actin nucleator Cobl.
Ji Y, Koch D, González Delgado J, Günther M, Witte OW, Kessels MM, Frahm C, Qualmann B. Ji Y, et al. Among authors: witte ow. PLoS Biol. 2021 Dec 13;19(12):e3001399. doi: 10.1371/journal.pbio.3001399. eCollection 2021 Dec. PLoS Biol. 2021. PMID: 34898601 Free PMC article.
Ischemic stroke is a major cause of death and long-term disability. We demonstrate that middle cerebral artery occlusion (MCAO) in mice leads to a strong decline in dendritic arborization of penumbral neurons. ...
Ischemic stroke is a major cause of death and long-term disability. We demonstrate that middle cerebral artery occlusion (MCAO) in mi …
Adult Neurogenesis and Stroke: A Tale of Two Neurogenic Niches.
Ceanga M, Dahab M, Witte OW, Keiner S. Ceanga M, et al. Among authors: witte ow. Front Neurosci. 2021 Aug 10;15:700297. doi: 10.3389/fnins.2021.700297. eCollection 2021. Front Neurosci. 2021. PMID: 34447293 Free PMC article. Review.
As such, the beneficial or maladaptive effect of some stroke-induced cellular responses is unclear, restricting the advancement of therapeutic strategies to target long-term complications. A prominent delayed effect of stroke is the robust increase in adult neurogenesis, w …
As such, the beneficial or maladaptive effect of some stroke-induced cellular responses is unclear, restricting the advancement of therapeut …
Weather conditions associated with subarachnoid hemorrhage: a multicenter case-crossover study.
Kockler M, Schlattmann P, Walther M, Hagemann G, Becker PN, Rosahl S, Witte OW, Schwab M, Rakers F. Kockler M, et al. Among authors: witte ow. BMC Neurol. 2021 Jul 19;21(1):283. doi: 10.1186/s12883-021-02312-7. BMC Neurol. 2021. PMID: 34281522 Free PMC article.
In the light of increasing climate variability and change, we investigated weather and rapid weather changes as possible short-term risk factors for SAH. METHODS: Seven hundred ninety one patients admitted to three major hospitals in Germany for non-traumatic SAH with a de …
In the light of increasing climate variability and change, we investigated weather and rapid weather changes as possible short-term r …
A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior.
Graf J, Zhang C, Marguet SL, Herrmann T, Flossmann T, Hinsch R, Rahmati V, Guenther M, Frahm C, Urbach A, Neves RM, Witte OW, Kiebel SJ, Isbrandt D, Hübner CA, Holthoff K, Kirmse K. Graf J, et al. Among authors: witte ow. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e2014784118. doi: 10.1073/pnas.2014784118. Proc Natl Acad Sci U S A. 2021. PMID: 33782119 Free PMC article.
In vivo, it has a minor impact on correlated spontaneous activity in the hippocampus and does not affect network activity in the intact visual cortex. Moreover, long-term effects of the developmental NKCC1 deletion on synaptic maturation, network dynamics, and behavioral p …
In vivo, it has a minor impact on correlated spontaneous activity in the hippocampus and does not affect network activity in the intact visu …
A case-crossover study on the effect of short-term exposure to moderate levels of air pollution on the risk of heart failure.
Huschmann A, Rasche M, Schlattmann P, Witte OW, Schwab M, Schulze PC, Rakers F. Huschmann A, et al. Among authors: witte ow. ESC Heart Fail. 2020 Dec;7(6):3851-3858. doi: 10.1002/ehf2.12977. Epub 2020 Sep 13. ESC Heart Fail. 2020. PMID: 32924321 Free PMC article.
The aim of this study was to evaluate the association between short-term exposure to moderate levels of air pollution with the risk of HF in a city with good air quality. ...CONCLUSIONS: In an area with only moderate air pollution, short-term exposure to major air p …
The aim of this study was to evaluate the association between short-term exposure to moderate levels of air pollution with the risk o …
Outcome of Older Patients with Acute Neuropsychological Symptoms Not Fulfilling Criteria of Delirium.
Zipprich HM, Arends MC, Schumacher U, Bahr V, Scherag A, Kwetkat A, Wedding U, Brunkhorst FM, Witte OW, Prell T, Redecker C. Zipprich HM, et al. Among authors: witte ow. J Am Geriatr Soc. 2020 Jul;68(7):1469-1475. doi: 10.1111/jgs.16422. Epub 2020 Mar 20. J Am Geriatr Soc. 2020. PMID: 32198768
Our aim was to determine point prevalence, predictors, and long-term outcomes of delirium and acute neuropsychological changes in patients aged 60 years and older across different departments of a university hospital with general inpatient care. ...
Our aim was to determine point prevalence, predictors, and long-term outcomes of delirium and acute neuropsychological changes in pat …
54 results