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Bed-rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism.
Shur NF, Simpson EJ, Crossland H, Constantin D, Cordon SM, Constantin-Teodosiu D, Stephens FB, Brook MS, Atherton PJ, Smith K, Wilkinson DJ, Mougin OE, Bradley C, Macdonald IA, Greenhaff PL. Shur NF, et al. Among authors: wilkinson dj. J Cachexia Sarcopenia Muscle. 2024 Apr;15(2):603-614. doi: 10.1002/jcsm.13431. Epub 2024 Feb 12. J Cachexia Sarcopenia Muscle. 2024. PMID: 38343303 Free PMC article.
BACKGROUND: Bed-rest (BR) of only a few days duration reduces muscle protein synthesis and induces skeletal muscle atrophy and insulin resistance, but the scale and juxtaposition of these events have not been investigated concurrently in the same individuals. Moreover, the impact …
BACKGROUND: Bed-rest (BR) of only a few days duration reduces muscle protein synthesis and induces skeletal muscle atrophy and insulin resis …
A single bout of prior resistance exercise attenuates muscle atrophy and declines in myofibrillar protein synthesis during bed-rest in older men.
Smeuninx B, Elhassan YS, Sapey E, Rushton AB, Morgan PT, Korzepa M, Belfield AE, Philp A, Brook MS, Gharahdaghi N, Wilkinson D, Smith K, Atherton PJ, Breen L. Smeuninx B, et al. Among authors: wilkinson d. J Physiol. 2023 Oct 19. doi: 10.1113/JP285130. Online ahead of print. J Physiol. 2023. PMID: 37856286
These findings suggest that concise resistance exercise intervention holds the potential to support muscle mass retention in older individuals during short-term disuse, with implications for delaying sarcopenia progression in ageing populations....
These findings suggest that concise resistance exercise intervention holds the potential to support muscle mass retention in older individua …
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study.
C-MORE/PHOSP-COVID Collaborative Group. C-MORE/PHOSP-COVID Collaborative Group. Lancet Respir Med. 2023 Nov;11(11):1003-1019. doi: 10.1016/S2213-2600(23)00262-X. Epub 2023 Sep 22. Lancet Respir Med. 2023. PMID: 37748493 Free PMC article.
INTERPRETATION: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeu …
INTERPRETATION: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings e …
A focus on leucine in the nutritional regulation of human skeletal muscle metabolism in ageing, exercise and unloading states.
Ely IA, Phillips BE, Smith K, Wilkinson DJ, Piasecki M, Breen L, Larsen MS, Atherton PJ. Ely IA, et al. Among authors: wilkinson dj. Clin Nutr. 2023 Oct;42(10):1849-1865. doi: 10.1016/j.clnu.2023.08.010. Epub 2023 Aug 12. Clin Nutr. 2023. PMID: 37625315 Free article. Review.
Layering exercise on top of protein intake increases the sensitivity of SKM to EAA, therefore extending the muscle full set-point (48 h), to permit long-term remodelling (e.g., hypertrophy). In contrast, ageing and physical inactivity are associated with a premature muscle …
Layering exercise on top of protein intake increases the sensitivity of SKM to EAA, therefore extending the muscle full set-point (48 h), to …
Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study.
Jackson C, Stewart ID, Plekhanova T, Cunningham PS, Hazel AL, Al-Sheklly B, Aul R, Bolton CE, Chalder T, Chalmers JD, Chaudhuri N, Docherty AB, Donaldson G, Edwardson CL, Elneima O, Greening NJ, Hanley NA, Harris VC, Harrison EM, Ho LP, Houchen-Wolloff L, Howard LS, Jolley CJ, Jones MG, Leavy OC, Lewis KE, Lone NI, Marks M, McAuley HJC, McNarry MA, Patel BV, Piper-Hanley K, Poinasamy K, Raman B, Richardson M, Rivera-Ortega P, Rowland-Jones SL, Rowlands AV, Saunders RM, Scott JT, Sereno M, Shah AM, Shikotra A, Singapuri A, Stanel SC, Thorpe M, Wootton DG, Yates T, Gisli Jenkins R, Singh SJ, Man WD, Brightling CE, Wain LV, Porter JC, Thompson AAR, Horsley A, Molyneaux PL, Evans RA, Jones SE, Rutter MK, Blaikley JF; PHOSP-COVID Study Collaborative Group. Jackson C, et al. Lancet Respir Med. 2023 Aug;11(8):673-684. doi: 10.1016/S2213-2600(23)00124-8. Epub 2023 Apr 15. Lancet Respir Med. 2023. PMID: 37072018 Free PMC article.
A comparison of short-term outcomes following robotic-assisted vs. open transthoracic diaphragm plication.
Stuart CM, Wojcik BM, Gergen AK, Wilkinson DA, Helmkamp LJ, Volker EE, Mitchell JD, Weyant MJ, Meguid RA, Scott CD. Stuart CM, et al. Among authors: wilkinson da. J Robot Surg. 2023 Aug;17(4):1787-1796. doi: 10.1007/s11701-023-01585-z. Epub 2023 Apr 18. J Robot Surg. 2023. PMID: 37071233
Symptomatic patients may benefit from surgical plication of the elevated hemidiaphragm. The objective of this study was to compare short-term outcomes and length of stay following robotic-assisted vs. open diaphragm plication. ...
Symptomatic patients may benefit from surgical plication of the elevated hemidiaphragm. The objective of this study was to compare short- …
Exploring the reasons for labour market gender inequality a year into the COVID-19 pandemic: evidence from the UK cohort studies.
Wielgoszewska B, Bryson A, Costa Dias M, Foliano F, Joshi H, Wilkinson D. Wielgoszewska B, et al. Among authors: wilkinson d. Longit Life Course Stud. 2023 Mar 13;14(2):180-202. doi: 10.1332/175795921X16751166213852. Longit Life Course Stud. 2023. PMID: 37022328
These effects may be long-lasting and jeopardise women's longer-term position through the loss of experience, leading to reinforcement of gender inequalities or even reversal of the progress towards gender equality....
These effects may be long-lasting and jeopardise women's longer-term position through the loss of experience, leading to reinforcemen …
Laparoscopic hernia repair in children: does recreating the open operation improve outcomes? A systematic review.
Goneidy A, Verhoef C, Lansdale N, Peters RT, Wilkinson DJ. Goneidy A, et al. Among authors: wilkinson dj. Hernia. 2023 Oct;27(5):1037-1046. doi: 10.1007/s10029-023-02772-5. Epub 2023 Mar 23. Hernia. 2023. PMID: 36949270 Free PMC article.
This may be explained by the range of different techniques currently included under the term laparoscopic inguinal hernia repair. The purpose of this study is to determine whether dividing the hernia sac before ligation improves surgical outcomes following a paediatric lap …
This may be explained by the range of different techniques currently included under the term laparoscopic inguinal hernia repair. The …
Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study.
McAuley HJC, Evans RA, Bolton CE, Brightling CE, Chalmers JD, Docherty AB, Elneima O, Greenhaff PL, Gupta A, Harris VC, Harrison EM, Ho LP, Horsley A, Houchen-Wolloff L, Jolley CJ, Leavy OC, Lone NI, Man WD, Marks M, Parekh D, Poinasamy K, Quint JK, Raman B, Richardson M, Saunders RM, Sereno M, Shikotra A, Singapuri A, Singh SJ, Steiner M, Tan AL, Wain LV, Welch C, Whitney J, Witham MD, Lord J, Greening NJ; PHOSP-COVID Study Collaborative Group. McAuley HJC, et al. EClinicalMedicine. 2023 Mar 11;57:101896. doi: 10.1016/j.eclinm.2023.101896. eCollection 2023 Mar. EClinicalMedicine. 2023. PMID: 36936404 Free PMC article.
BACKGROUND: The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes including frailty. ...
BACKGROUND: The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes i …
School-age outcomes among IVF-conceived children: A population-wide cohort study.
Kennedy AL, Vollenhoven BJ, Hiscock RJ, Stern CJ, Walker SP, Cheong JLY, Quach JL, Hastie R, Wilkinson D, McBain J, Gurrin LC, MacLachlan V, Agresta F, Baohm SP, Tong S, Lindquist AC. Kennedy AL, et al. Among authors: wilkinson d. PLoS Med. 2023 Jan 24;20(1):e1004148. doi: 10.1371/journal.pmed.1004148. eCollection 2023 Jan. PLoS Med. 2023. PMID: 36693021 Free PMC article. Clinical Trial.
BACKGROUND: In vitro fertilisation (IVF) is a common mode of conception. Understanding the long-term implications for these children is important. The aim of this study was to determine the causal effect of IVF conception on primary school-age childhood developmental and e …
BACKGROUND: In vitro fertilisation (IVF) is a common mode of conception. Understanding the long-term implications for these children …
122 results