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Immortalised murine R349P desmin knock-in myotubes exhibit a reduced proton leak and decreased ADP/ATP translocase levels in purified mitochondria.
Berwanger C, Terres D, Pesta D, Eggers B, Marcus K, Wittig I, Wiesner RJ, Schröder R, Clemen CS. Berwanger C, et al. Among authors: wiesner rj. Eur J Cell Biol. 2024 Feb 20;103(2):151399. doi: 10.1016/j.ejcb.2024.151399. Online ahead of print. Eur J Cell Biol. 2024. PMID: 38412640 Free article.
The desminopathy myoblasts showed the characteristic disruption of the desmin cytoskeleton and desmin protein aggregation, and the desminopathy myotubes showed the characteristic myofibrillar irregularities. Long-term electrical pulse stimulation promoted myotube different …
The desminopathy myoblasts showed the characteristic disruption of the desmin cytoskeleton and desmin protein aggregation, and the desminopa …
Liver adapts mitochondrial function to insulin resistant and diabetic states in mice.
Franko A, von Kleist-Retzow JC, Neschen S, Wu M, Schommers P, Böse M, Kunze A, Hartmann U, Sanchez-Lasheras C, Stoehr O, Huntgeburth M, Brodesser S, Irmler M, Beckers J, de Angelis MH, Paulsson M, Schubert M, Wiesner RJ. Franko A, et al. Among authors: wiesner rj. J Hepatol. 2014 Apr;60(4):816-23. doi: 10.1016/j.jhep.2013.11.020. Epub 2013 Nov 28. J Hepatol. 2014. PMID: 24291365
BACKGROUND & AIMS: To determine if diabetic and insulin-resistant states cause mitochondrial dysfunction in liver or if there is long term adaptation of mitochondrial function to these states, mice were (i) fed with a high-fat diet to induce obesity and T2D (HFD), (ii) …
BACKGROUND & AIMS: To determine if diabetic and insulin-resistant states cause mitochondrial dysfunction in liver or if there is long …
Respiratory chain deficiency slows down cell-cycle progression via reduced ROS generation and is associated with a reduction of p21CIP1/WAF1.
Schauen M, Spitkovsky D, Schubert J, Fischer JH, Hayashi J, Wiesner RJ. Schauen M, et al. Among authors: wiesner rj. J Cell Physiol. 2006 Oct;209(1):103-12. doi: 10.1002/jcp.20711. J Cell Physiol. 2006. PMID: 16775840
We have used HeLa cells without mitochondrial DNA (rho0-cells) and transient rho0-phenocopies, obtained from wild-type cells by short-term treatment with ethidium bromide, to analyze how the absence of a functional mitochondrial respiratory chain slows down proliferation. …
We have used HeLa cells without mitochondrial DNA (rho0-cells) and transient rho0-phenocopies, obtained from wild-type cells by short-ter …
Cultivation in glucose-deprived medium stimulates mitochondrial biogenesis and oxidative metabolism in HepG2 hepatoma cells.
Weber K, Ridderskamp D, Alfert M, Hoyer S, Wiesner RJ. Weber K, et al. Among authors: wiesner rj. Biol Chem. 2002 Feb;383(2):283-90. doi: 10.1515/BC.2002.030. Biol Chem. 2002. PMID: 11934266
Lactate production was significantly reduced and glutamine was consumed as an alternative substrate for oxidative metabolism. Long-term adapted cells formed exclusively monolayers, while they normally grow in multilayers forming tumor spheroids. Also, long-term adap …
Lactate production was significantly reduced and glutamine was consumed as an alternative substrate for oxidative metabolism. Long-term …
Denervated chicken breast muscle displays discoordinate regulation and differential patterns of expression of alpha f and beta tropomyosin genes.
Gupta MP, Wiesner RJ, Mouly V, Zak R, Lemonnier M. Gupta MP, et al. Among authors: wiesner rj. J Muscle Res Cell Motil. 1993 Aug;14(4):377-84. doi: 10.1007/BF00121288. J Muscle Res Cell Motil. 1993. PMID: 8227295
No such translation block is seen with RNA obtained from control or muscles denervated for 6 weeks. (2) No changes in the alpha fTM mRNA and corresponding protein are observed. (3) RNA processing of the two genes is not changed. (4) In the contralateral muscles, transitory increa …
No such translation block is seen with RNA obtained from control or muscles denervated for 6 weeks. (2) No changes in the alpha fTM mRNA and …