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Synaptogenic effect of APP-Swedish mutation in familial Alzheimer's disease.
Zhou B, Lu JG, Siddu A, Wernig M, Südhof TC. Zhou B, et al. Among authors: wernig m. Sci Transl Med. 2022 Oct 19;14(667):eabn9380. doi: 10.1126/scitranslmed.abn9380. Epub 2022 Oct 19. Sci Transl Med. 2022. PMID: 36260691 Free PMC article.
These data are consistent with the relative inefficacy of BACE1 and anti-Abeta treatments in AD and the chronic nature of AD pathogenesis, suggesting that AD pathogenesis is not simply caused by overproduction of toxic Abeta but rather by a long-term effect of elevated Abe …
These data are consistent with the relative inefficacy of BACE1 and anti-Abeta treatments in AD and the chronic nature of AD pathogenesis, s …
Reversible Disruption of Specific Transcription Factor-DNA Interactions Using CRISPR/Cas9.
Shariati SA, Dominguez A, Xie S, Wernig M, Qi LS, Skotheim JM. Shariati SA, et al. Among authors: wernig m. Mol Cell. 2019 May 2;74(3):622-633.e4. doi: 10.1016/j.molcel.2019.04.011. Mol Cell. 2019. PMID: 31051141 Free PMC article.
Here, we use deactivated Cas9 (dCas9) to disrupt binding to specific sites, a method we term CRISPRd. Since CRISPR guide RNAs are longer than transcription factor binding sites, flanking sequence can be used to target specific sites. ...
Here, we use deactivated Cas9 (dCas9) to disrupt binding to specific sites, a method we term CRISPRd. Since CRISPR guide RNAs are lon …
In Vivo Reprogramming for Brain and Spinal Cord Repair.
Chen G, Wernig M, Berninger B, Nakafuku M, Parmar M, Zhang CL. Chen G, et al. Among authors: wernig m. eNeuro. 2015 Nov 9;2(5):ENEURO.0106-15.2015. doi: 10.1523/ENEURO.0106-15.2015. eCollection 2015 Sep-Oct. eNeuro. 2015. PMID: 26730402 Free PMC article. Review.
However, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival, and functional integration after transplantation. ...
However, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival, and funct …
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency.
Hanna J, Markoulaki S, Schorderet P, Carey BW, Beard C, Wernig M, Creyghton MP, Steine EJ, Cassady JP, Foreman R, Lengner CJ, Dausman JA, Jaenisch R. Hanna J, et al. Among authors: wernig m. Cell. 2008 Apr 18;133(2):250-64. doi: 10.1016/j.cell.2008.03.028. Cell. 2008. PMID: 18423197 Free PMC article.
Multiple iPS lines were clonally derived from both nonfully and fully differentiated B lymphocytes, which gave rise to adult chimeras with germline contribution, and to late-term embryos when injected into tetraploid blastocysts. Our study provides definite proof for the d …
Multiple iPS lines were clonally derived from both nonfully and fully differentiated B lymphocytes, which gave rise to adult chimeras with g …
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease.
Wernig M, Zhao JP, Pruszak J, Hedlund E, Fu D, Soldner F, Broccoli V, Constantine-Paton M, Isacson O, Jaenisch R. Wernig M, et al. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5856-61. doi: 10.1073/pnas.0801677105. Epub 2008 Apr 7. Proc Natl Acad Sci U S A. 2008. PMID: 18391196 Free PMC article.
The long-term goal of nuclear transfer or alternative reprogramming approaches is to create patient-specific donor cells for transplantation therapy, avoiding immunorejection, a major complication in current transplantation medicine. ...
The long-term goal of nuclear transfer or alternative reprogramming approaches is to create patient-specific donor cells for transpla …
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.
Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, Bernstein BE, Jaenisch R. Wernig M, et al. Nature. 2007 Jul 19;448(7151):318-24. doi: 10.1038/nature05944. Epub 2007 Jun 6. Nature. 2007. PMID: 17554336
Notably, the cells-derived from mouse fibroblasts-can form viable chimaeras, can contribute to the germ line and can generate live late-term embryos when injected into tetraploid blastocysts. Our results show that the biological potency and epigenetic state of in-vitro-rep …
Notably, the cells-derived from mouse fibroblasts-can form viable chimaeras, can contribute to the germ line and can generate live late-t …
Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures.
Benninger F, Beck H, Wernig M, Tucker KL, Brüstle O, Scheffler B. Benninger F, et al. Among authors: wernig m. J Neurosci. 2003 Aug 6;23(18):7075-83. doi: 10.1523/JNEUROSCI.23-18-07075.2003. J Neurosci. 2003. PMID: 12904468 Free PMC article.
Here, we use ES cells engineered to express enhanced green fluorescent protein (EGFP) only in neuronal progeny to study the functional properties of ESNs during integration into long-term hippocampal slice cultures. After incorporation into the dentate gyrus, EGFP+ donor n …
Here, we use ES cells engineered to express enhanced green fluorescent protein (EGFP) only in neuronal progeny to study the functional prope …