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Comparison of clinical outcomes in hospitalized patients with COVID-19 or non-COVID-19 community-acquired pneumonia in a prospective observational cohort study.
Meyer HJ, Mödl L, Unruh O, Xiang W, Berger S, Müller-Plathe M, Rohde G, Pletz MW, Rupp J, Suttorp N, Witzenrath M, Zoller T, Mittermaier M, Steinbeis F; CAPNETZ study group. Meyer HJ, et al. Infection. 2024 May 18. doi: 10.1007/s15010-024-02292-z. Online ahead of print. Infection. 2024. PMID: 38761325
PURPOSE: Coronavirus disease 2019 (COVID-19) and non-COVID-19 community-acquired pneumonia (NC-CAP) often result in hospitalization with considerable risks of mortality, ICU treatment, and long-term morbidity. A comparative analysis of clinical outcomes in COVID-19 CAP (C- …
PURPOSE: Coronavirus disease 2019 (COVID-19) and non-COVID-19 community-acquired pneumonia (NC-CAP) often result in hospitalization with con …
Statins did not reduce the frequency of exacerbations in individuals with COPD and cardiovascular comorbidities in the COSYCONET cohort.
Frantzi N, Nguyen XP, Herr C, Alter P, Söhler S, Soriano D, Watz H, Waschki B, Trinkmann F, Eichenlaub M, Trudzinski FC, Michels-Zetsche JD, Omlor A, Seiler F, Moneke I, Biertz F, Rohde G, Stolz D, Welte T, Kauczor HU, Kahnert K, Jörres RA, Vogelmeier CF, Bals R, Fähndrich S; German COSYCONET Cohort. Frantzi N, et al. Among authors: welte t. Respir Res. 2024 May 15;25(1):207. doi: 10.1186/s12931-024-02822-1. Respir Res. 2024. PMID: 38750572 Free PMC article.
Other Study ID (BMBF grant): 01GI0881, registered 18 November 2010, study start 2010-11, primary completion 2013-12, study completion 2023-09. https://clinicaltrials.gov/study/NCT01245933?cond=COPD&term=COSYCONET&rank=3....
Other Study ID (BMBF grant): 01GI0881, registered 18 November 2010, study start 2010-11, primary completion 2013-12, study completion 2023-0 …
Long-term multicenter comparison shows equivalent efficacy of monoclonal antibodies in severe asthma therapy.
Kayser MZ, Suhling H, Fuge J, Hinze CA, Drick N, Kneidinger N, Behr J, Taube C, Welte T, Haasler I, Milger K. Kayser MZ, et al. Among authors: welte t. BMC Pulm Med. 2024 Mar 21;24(1):149. doi: 10.1186/s12890-024-02964-4. BMC Pulm Med. 2024. PMID: 38515071 Free PMC article.
While all biologics are efficient individually, the choice of biologic is complicated by insufficient data on their comparative long-term treatment efficacy. Here, we compare the real-life efficacy of these biologics in asthma therapy over 12 months. ...
While all biologics are efficient individually, the choice of biologic is complicated by insufficient data on their comparative long-term …
Alveolar membrane and capillary function in COVID-19 convalescents: insights from chest MRI.
Kern AL, Pink I, Bonifacius A, Kaireit T, Speth M, Behrendt L, Klimeš F, Voskrebenzev A, Hohlfeld JM, Hoeper MM, Welte T, Wacker F, Eiz-Vesper B, Vogel-Claussen J. Kern AL, et al. Among authors: welte t. Eur Radiol. 2024 Mar 9. doi: 10.1007/s00330-024-10669-9. Online ahead of print. Eur Radiol. 2024. PMID: 38460013
OBJECTIVES: To investigate potential presence and resolution of longer-term pulmonary diffusion limitation and microvascular perfusion impairment in COVID-19 convalescents. ...CLINICAL RELEVANCE STATEMENT: (129)Xe MRI shows improvement of microvascular pulmonary perfusion …
OBJECTIVES: To investigate potential presence and resolution of longer-term pulmonary diffusion limitation and microvascular perfusio …
Oversizing lung allografts deteriorates outcomes in patients with pulmonary fibrosis.
Franz M, Tavil S, de Manna ND, Aburahma K, Boethig D, Bobylev D, Welte T, Greer M, Schwerk N, Ruhparwar A, Kuehn C, Salman J, Ius F. Franz M, et al. Among authors: welte t. J Heart Lung Transplant. 2024 Mar 2:S1053-2498(24)01516-X. doi: 10.1016/j.healun.2024.02.1460. Online ahead of print. J Heart Lung Transplant. 2024. PMID: 38438087 Free article.

Patients from the oversized group had a higher PGD grade 3 rate at 24 (p < 0.001), 48 (p < 0.001), and 72 (p = 0.039) hours after transplantation as well as a higher in-hospital mortality compared to the undersized group (p = 0.033). The long-term survival was also b

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Patients from the oversized group had a higher PGD grade 3 rate at 24 (p < 0.001), 48 (p < 0.001), and 72 (p = 0.039) hours after tran

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Effects of triple therapy on disease burden in patients of GOLD groups C and D: results from the observational COPD cohort COSYCONET.
Zader JA, Jörres RA, Mayer I, Alter P, Bals R, Watz H, Mertsch P, Rabe KF, Herth F, Trudzinski FC, Welte T, Kauczor HU, Behr J, Walter J, Vogelmeier CF, Kahnert K. Zader JA, et al. Among authors: welte t. BMC Pulm Med. 2024 Mar 1;24(1):103. doi: 10.1186/s12890-024-02902-4. BMC Pulm Med. 2024. PMID: 38424530 Free PMC article.
These findings are compatible with beneficial effects of triple therapy under continuous, long-term treatment, but also demonstrate the limitations encountered in the comparison of controlled intervention studies with observational studies in patients with severe COPD usin …
These findings are compatible with beneficial effects of triple therapy under continuous, long-term treatment, but also demonstrate t …
Atrial fibrillation and survival on a medical intensive care unit.
Rottmann FA, Abraham H, Welte T, Westermann L, Bemtgen X, Gauchel N, Supady A, Wengenmayer T, Staudacher DL. Rottmann FA, et al. Among authors: welte t. Int J Cardiol. 2024 Mar 15;399:131673. doi: 10.1016/j.ijcard.2023.131673. Epub 2023 Dec 22. Int J Cardiol. 2024. PMID: 38141732 Free article.
Patients who develop new-onset AF during their ICU stay warrant special attention for both short-term and long-term care strategies....
Patients who develop new-onset AF during their ICU stay warrant special attention for both short-term and long-term care strat …
HbA1c-dependent projection of long-term renal outcomes.
Arnold F, Kappes J, Rottmann FA, Westermann L, Welte T. Arnold F, et al. Among authors: welte t. J Intern Med. 2024 Feb;295(2):206-215. doi: 10.1111/joim.13736. Epub 2023 Nov 5. J Intern Med. 2024. PMID: 37925625
CYP19A1 mediates severe SARS-CoV-2 disease outcome in males.
Stanelle-Bertram S, Beck S, Mounogou NK, Schaumburg B, Stoll F, Al Jawazneh A, Schmal Z, Bai T, Zickler M, Beythien G, Becker K, de la Roi M, Heinrich F, Schulz C, Sauter M, Krasemann S, Lange P, Heinemann A, van Riel D, Leijten L, Bauer L, van den Bosch TPP, Lopuhaä B, Busche T, Wibberg D, Schaudien D, Goldmann T, Lüttjohann A, Ruschinski J, Jania H, Müller Z, Pinho Dos Reis V, Krupp-Buzimkic V, Wolff M, Fallerini C, Baldassarri M, Furini S, Norwood K, Käufer C, Schützenmeister N, von Köckritz-Blickwede M, Schroeder M, Jarczak D, Nierhaus A, Welte T, Kluge S, McHardy AC, Sommer F, Kalinowski J, Krauss-Etschmann S, Richter F, von der Thüsen J, Baumgärtner W, Klingel K, Ondruschka B; GEN-COVID Multicenter Study Group; Renieri A, Gabriel G. Stanelle-Bertram S, et al. Among authors: welte t. Cell Rep Med. 2023 Sep 19;4(9):101152. doi: 10.1016/j.xcrm.2023.101152. Epub 2023 Aug 12. Cell Rep Med. 2023. PMID: 37572667 Free PMC article.
In the golden hamster model, we show that SARS-CoV-2 infection causes increased CYP19A1 expression in the lung that is associated with dysregulated plasma sex hormone levels and reduced long-term pulmonary function in males but not females. Treatment of SARS-CoV-2-infected …
In the golden hamster model, we show that SARS-CoV-2 infection causes increased CYP19A1 expression in the lung that is associated with dysre …
Analysis of acute COVID-19 including chronic morbidity: protocol for the deep phenotyping National Pandemic Cohort Network in Germany (NAPKON-HAP).
Steinbeis F, Thibeault C, Steinbrecher S, Ahlgrimm Y, Haack IA, August D, Balzuweit B, Bellinghausen C, Berger S, Chaplinskaya-Sobol I, Cornely O, Doeblin P, Endres M, Fink C, Finke C, Frank S, Hanß S, Hartung T, Hellmuth JC, Herold S, Heuschmann P, Heyckendorf J, Heyder R, Hippenstiel S, Hoffmann W, Kelle SU, Knape P, Koehler P, Kretzler L, Leistner DM, Lienau J, Lorbeer R, Lorenz-Depiereux B, Lüttke CD, Mai K, Merle U, Meyer-Arndt LA, Miljukov O, Muenchhoff M, Müller-Plathe M, Neuhann J, Neuhauser H, Nieters A, Otte C, Pape D, Pinto RM, Pley C, Pudszuhn A, Reuken P, Rieg S, Ritter P, Rohde G, Rönnefarth M, Ruzicka M, Schaller J, Schmidt A, Schmidt S, Schwachmeyer V, Schwanitz G, Seeger W, Stahl D, Stobäus N, Stubbe HC, Suttorp N, Temmesfeld B, Thun S, Triller P, Trinkmann F, Vadasz I, Valentin H, Vehreschild M, von Kalle C, von Lilienfeld-Toal M, Weber J, Welte T, Wildberg C, Wizimirski R, Zvork S, Sander LE, Vehreschild J, Zoller T, Kurth F, Witzenrath M. Steinbeis F, et al. Among authors: welte t. Infection. 2024 Feb;52(1):93-104. doi: 10.1007/s15010-023-02057-0. Epub 2023 Jul 11. Infection. 2024. PMID: 37434025 Free PMC article.
BACKGROUND: The severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) pandemic causes a high burden of acute and long-term morbidity and mortality worldwide despite global efforts in containment, prophylaxis, and therapy. ...METHODS: NAPKON-HAP is a multi-centered …
BACKGROUND: The severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) pandemic causes a high burden of acute and long-term mo …
104 results