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Perinatal complications and maximising lamb survival in an adolescent paradigm characterised by premature delivery and low birthweight.
Wallace JM, Shepherd PO, Milne JS, Aitken RP. Wallace JM, et al. PLoS One. 2021 Nov 15;16(11):e0259890. doi: 10.1371/journal.pone.0259890. eCollection 2021. PLoS One. 2021. PMID: 34780509 Free PMC article.
Accordingly, overnourished dams were more likely to lamb without assistance while the incidence of major dystocia was greater in controls. Initial lamb vigour at birth was independent of gestational-intake, delivery or birthweight category but both ELBW and very premature …
Accordingly, overnourished dams were more likely to lamb without assistance while the incidence of major dystocia was greater in controls. I …
Early pregnancy weight gain and fat accrual predict pregnancy outcome in growing adolescent sheep.
Wallace JM, Milne JS, Aitken RP. Wallace JM, et al. Reproduction. 2021 Mar;161(3):227-238. doi: 10.1530/REP-20-0533. Reproduction. 2021. PMID: 33275119

GWG during this early period was also higher in PlGR compared with non-PlGR, and in very preterm vs term deliveries (P < 0.01). Likewise maternal leptin concentrations (fat accrual biomarker) were FGR > non-FGR by day 60, and changes in leptin throughout pregnancy pr

…

GWG during this early period was also higher in PlGR compared with non-PlGR, and in very preterm vs term deliveries (P < 0.01). Li

…
Zoledronate and Raloxifene combination therapy enhances material and mechanical properties of diseased mouse bone.
Powell KM, Skaggs C, Pulliam A, Berman A, Allen MR, Wallace JM. Powell KM, et al. Among authors: wallace jm. Bone. 2019 Oct;127:199-206. doi: 10.1016/j.bone.2019.06.018. Epub 2019 Jun 21. Bone. 2019. PMID: 31233931 Free PMC article.
Bisphosphonates, such as Zoledronate (ZOL), are used to treat a variety of bone disorders by increasing bone mass to decrease fracture risk, but long-term use has been shown in some settings to compromise bone quality. ...
Bisphosphonates, such as Zoledronate (ZOL), are used to treat a variety of bone disorders by increasing bone mass to decrease fracture risk, …
Raloxifene Improves Bone Mechanical Properties in Mice Previously Treated with Zoledronate.
Meixner CN, Aref MW, Gupta A, McNerny EMB, Brown D, Wallace JM, Allen MR. Meixner CN, et al. Among authors: wallace jm. Calcif Tissue Int. 2017 Jul;101(1):75-81. doi: 10.1007/s00223-017-0257-4. Epub 2017 Feb 28. Calcif Tissue Int. 2017. PMID: 28246928 Free PMC article.
Bisphosphonates represent the gold-standard pharmaceutical agent for reducing fracture risk. Long-term treatment with bisphosphonates can result in tissue brittleness which in rare clinical cases manifests as atypical femoral fracture. ...
Bisphosphonates represent the gold-standard pharmaceutical agent for reducing fracture risk. Long-term treatment with bisphosphonates …
Placental vascularity and markers of angiogenesis in relation to prenatal growth status in overnourished adolescent ewes.
Carr DJ, David AL, Aitken RP, Milne JS, Borowicz PP, Wallace JM, Redmer DA. Carr DJ, et al. Among authors: wallace jm. Placenta. 2016 Oct;46:79-86. doi: 10.1016/j.placenta.2016.08.076. Epub 2016 Aug 19. Placenta. 2016. PMID: 27697225 Free PMC article.
METHODS: Singleton pregnancies were established in adolescent ewes either overnourished to putatively restrict fetoplacental growth (n = 27) or control-fed (n = 12). At 131d (term = 145d) pregnancies were interrupted and fetuses classified as FGR (n = 17, <4222 g, -2SD …
METHODS: Singleton pregnancies were established in adolescent ewes either overnourished to putatively restrict fetoplacental growth (n = 27) …
Using NMR-Based Metabolomics to Evaluate Postprandial Urinary Responses Following Consumption of Minimally Processed Wheat Bran or Wheat Aleurone by Men and Women.
Garg R, Brennan L, Price RK, Wallace JM, Strain JJ, Gibney MJ, Shewry PR, Ward JL, Garg L, Welch RW. Garg R, et al. Among authors: wallace jm. Nutrients. 2016 Feb 17;8(2):96. doi: 10.3390/nu8020096. Nutrients. 2016. PMID: 26901221 Free PMC article. Clinical Trial.
Overall, this postprandial study suggests that acute consumption of bran or aleurone is associated with a number of physiological effects that may impact on energy metabolism and which are consistent with longer term human and animal metabolomic studies that used whole-gra …
Overall, this postprandial study suggests that acute consumption of bran or aleurone is associated with a number of physiological effects th …
Orexigenic Gene Expression in Late Gestation Ovine Foetal Hypothalamus is Sensitive to Maternal Undernutrition and Realimentation.
Adam CL, Williams PA, Milne JS, Aitken RP, Wallace JM. Adam CL, et al. Among authors: wallace jm. J Neuroendocrinol. 2015 Oct;27(10):765-71. doi: 10.1111/jne.12302. J Neuroendocrinol. 2015. PMID: 26212239
Adverse nutritional effects on developing foetal hypothalamic appetitive pathways may contribute to programmed hyperphagia and obesity in intra-uterine growth-restricted, low birth weight offspring. In the present study, for the first time, hypothalamic gene expression for …
Adverse nutritional effects on developing foetal hypothalamic appetitive pathways may contribute to programmed hyperphagia and obesity in in …
Undernutrition and stage of gestation influence fetal adipose tissue gene expression.
Wallace JM, Milne JS, Aitken RP, Redmer DA, Reynolds LP, Luther JS, Horgan GW, Adam CL. Wallace JM, et al. J Mol Endocrinol. 2015 Jun;54(3):263-75. doi: 10.1530/JME-15-0048. Epub 2015 Apr 27. J Mol Endocrinol. 2015. PMID: 25917833 Free PMC article.
In the present study, we investigated the impact of maternal undernutrition on the expression of genes that regulate fetal perirenal adipose tissue (PAT) development and function at gestation days 89 and 130 (term=145 days). Singleton fetuses were taken from adolescent ewe …
In the present study, we investigated the impact of maternal undernutrition on the expression of genes that regulate fetal perirenal adipose …
Uteroplacental adenovirus vascular endothelial growth factor gene therapy increases fetal growth velocity in growth-restricted sheep pregnancies.
Carr DJ, Wallace JM, Aitken RP, Milne JS, Mehta V, Martin JF, Zachary IC, Peebles DM, David AL. Carr DJ, et al. Among authors: wallace jm. Hum Gene Ther. 2014 Apr;25(4):375-84. doi: 10.1089/hum.2013.214. Epub 2014 Apr 7. Hum Gene Ther. 2014. PMID: 24593228 Free PMC article.
Herein we evaluated Ad.VEGF therapy in the overnourished adolescent ewe, an experimental paradigm in which reduced UBF from midgestation correlates with reduced lamb birthweight near term. Singleton pregnancies were established using embryo transfer in adolescent ewes subs …
Herein we evaluated Ad.VEGF therapy in the overnourished adolescent ewe, an experimental paradigm in which reduced UBF from midgestation cor …
Impact of embryo donor adiposity, birthweight and gender on early postnatal growth, glucose metabolism and body composition in the young lamb.
Wallace JM, Milne JS, Aitken RP, Adam CL. Wallace JM, et al. Reprod Fertil Dev. 2014 Jun;26(5):665-81. doi: 10.1071/RD13090. Reprod Fertil Dev. 2014. PMID: 23714163
Gestation length was equivalent in both categories and all lambs were delivered spontaneously preterm (PT; mean (s.e.m.) 139.81.7 days; term=145-147 days). The IUGR lambs were smaller at birth, but fractional growth rates (FGR) for eight anthropometry parameters wer …
Gestation length was equivalent in both categories and all lambs were delivered spontaneously preterm (PT; mean (s.e.m.) 139.81.7 days; t …
51 results