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PCSK9 Inhibitors: potential in cardiovascular therapeutics.
Do RQ, Vogel RA, Schwartz GG. Do RQ, et al. Among authors: vogel ra. Curr Cardiol Rep. 2013 Mar;15(3):345. doi: 10.1007/s11886-012-0345-z. Curr Cardiol Rep. 2013. PMID: 23338726 Review.
In rare genetic experiments of nature, individuals with dominant negative or dual loss of function mutations of PCSK9 appear to have no adverse health effects resulting from lifelong, very low levels of LDL-C. In short-term trials, PCSK9 antibodies have been generally well …
In rare genetic experiments of nature, individuals with dominant negative or dual loss of function mutations of PCSK9 appear to have no adve …
Potential adverse cardiovascular effects from excessive endurance exercise.
O'Keefe JH, Patil HR, Lavie CJ, Magalski A, Vogel RA, McCullough PA. O'Keefe JH, et al. Among authors: vogel ra. Mayo Clin Proc. 2012 Jun;87(6):587-95. doi: 10.1016/j.mayocp.2012.04.005. Mayo Clin Proc. 2012. PMID: 22677079 Free PMC article. Review.
A routine of regular exercise is highly effective for prevention and treatment of many common chronic diseases and improves cardiovascular (CV) health and longevity. However, long-term excessive endurance exercise may induce pathologic structural remodeling of the heart an …
A routine of regular exercise is highly effective for prevention and treatment of many common chronic diseases and improves cardiovascular ( …
Effect of supplemental phytonutrients on impairment of the flow-mediated brachial artery vasoactivity after a single high-fat meal.
Plotnick GD, Corretti MC, Vogel RA, Hesslink R Jr, Wise JA. Plotnick GD, et al. Among authors: vogel ra. J Am Coll Cardiol. 2003 May 21;41(10):1744-9. doi: 10.1016/s0735-1097(03)00302-4. J Am Coll Cardiol. 2003. PMID: 12767658 Free article. Clinical Trial.
OBJECTIVES: Our objective was to determine if long-term daily administration of phytonutrient supplements can prevent the immediate adverse impact of a high-fat meal and increase the production of nitric oxide. ...
OBJECTIVES: Our objective was to determine if long-term daily administration of phytonutrient supplements can prevent the immediate a …
Measurement of endothelial function by brachial artery flow-mediated vasodilation.
Vogel RA. Vogel RA. Am J Cardiol. 2001 Jul 19;88(2A):31E-34E. doi: 10.1016/s0002-9149(01)01764-7. Am J Cardiol. 2001. PMID: 11473743
Brachial artery flow-mediated vasodilation correlates with coronary artery flow-mediated vasodilation. Both indexes have been shown to predict long-term cardiovascular events. Whereas the clinical applicability of brachial artery flow-mediated vasodilation is unclear, it h …
Brachial artery flow-mediated vasodilation correlates with coronary artery flow-mediated vasodilation. Both indexes have been shown to predi …
The Mediterranean diet and endothelial function: why some dietary fats may be healthy.
Vogel RA. Vogel RA. Cleve Clin J Med. 2000 Apr;67(4):232, 235-6. doi: 10.3949/ccjm.67.4.232. Cleve Clin J Med. 2000. PMID: 10780093 Free article.
Evidence from both diet and physiologic studies suggests that some dietary fats--but not others--impair endothelial function in the short term, possibly by a mechanism of oxidative stress. This insight may affect our advice to patients about heart-healthy eating....
Evidence from both diet and physiologic studies suggests that some dietary fats--but not others--impair endothelial function in the short …
Cholesterol, cholesterol lowering, and endothelial function.
Vogel RA, Corretti MC, Gellman J. Vogel RA, et al. Prog Cardiovasc Dis. 1998 Sep-Oct;41(2):117-36. doi: 10.1016/s0033-0620(98)80008-x. Prog Cardiovasc Dis. 1998. PMID: 9790413 Review.
Several studies have shown improvements in endothelial function with cholesterol lowering in both normal individuals and those with coronary heart disease. Short-term improvements in endothelial-dependent vasodilation and adhesion molecule expression have also been reporte …
Several studies have shown improvements in endothelial function with cholesterol lowering in both normal individuals and those with coronary …
Effect of beta-blockade on mortality among high-risk and low-risk patients after myocardial infarction.
Gottlieb SS, McCarter RJ, Vogel RA. Gottlieb SS, et al. Among authors: vogel ra. N Engl J Med. 1998 Aug 20;339(8):489-97. doi: 10.1056/NEJM199808203390801. N Engl J Med. 1998. PMID: 9709041 Free article.
BACKGROUND: Long-term administration of beta-adrenergic blockers to patients after myocardial infarction improves survival. ...
BACKGROUND: Long-term administration of beta-adrenergic blockers to patients after myocardial infarction improves survival. ...
Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal.
Plotnick GD, Corretti MC, Vogel RA. Plotnick GD, et al. Among authors: vogel ra. JAMA. 1997 Nov 26;278(20):1682-6. JAMA. 1997. PMID: 9388088 Clinical Trial.
CONTEXT: Much has been written about the potential role of antioxidants in the prevention of atherosclerosis. OBJECTIVE: To assess the short-term effect of a single high-fat meal with and without pretreatment with antioxidant vitamins on endothelial function in healthy, no …
CONTEXT: Much has been written about the potential role of antioxidants in the prevention of atherosclerosis. OBJECTIVE: To assess the short …
Short-term low dose intracoronary diltiazem administered at the onset of reperfusion reduces myocardial infarct size.
Herzog WR, Vogel RA, Schlossberg ML, Edenbaum LR, Scott HJ, Serebruany VL. Herzog WR, et al. Among authors: vogel ra. Int J Cardiol. 1997 Mar;59(1):21-7. doi: 10.1016/s0167-5273(96)02883-5. Int J Cardiol. 1997. PMID: 9080022
METHODS AND RESULTS: This experiment evaluated the effect of intracoronary short term low dose diltiazem administration given immediately with postischemic myocardial reperfusion. ...Infarct size was 0.13+/-0.06 g/kg of body weight for diltiazem group, and 0.42+/-0.04 g/kg …
METHODS AND RESULTS: This experiment evaluated the effect of intracoronary short term low dose diltiazem administration given immedia …
National Registry for Supported Angioplasty: results and follow-up of three years of supported and standby supported angioplasty in high-risk patients.
Tommaso CL, Vogel RA. Tommaso CL, et al. Among authors: vogel ra. Cardiology. 1994;84(3):238-44. doi: 10.1159/000176404. Cardiology. 1994. PMID: 8205575
In addition, patients with LMCA stenosis and age > or = 70 years are at higher risk. The Registry also demonstrates good long-term results for patients who have undergone the procedure....
In addition, patients with LMCA stenosis and age > or = 70 years are at higher risk. The Registry also demonstrates good long-term …
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