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Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo.
Samer S, Thomas Y, Araínga M, Carter C, Shirreff LM, Arif MS, Avita JM, Frank I, McRaven MD, Thuruthiyil CT, Heybeli VB, Anderson MR, Owen B, Gaisin A, Bose D, Simons LM, Hultquist JF, Arthos J, Cicala C, Sereti I, Santangelo PJ, Lorenzo-Redondo R, Hope TJ, Villinger FJ, Martinelli E. Samer S, et al. Among authors: villinger fj. JCI Insight. 2022 Nov 8;7(21):e162290. doi: 10.1172/jci.insight.162290. JCI Insight. 2022. PMID: 36125890 Free PMC article.
Resting HIV-1 target cells represent the main cellular reservoir after long-term antiretroviral therapy (ART). We hypothesized that releasing cells from TGF-beta-driven signaling would promote latency reversal. ...In vivo, oral galunisertib promoted increased total standar …
Resting HIV-1 target cells represent the main cellular reservoir after long-term antiretroviral therapy (ART). We hypothesized that r …
Immune Priming and Long-term Persistence of Memory B Cells After Inactivated Poliovirus Vaccine in Macaque Models: Support for at least 2 Doses.
Bhaumik SK, Kulkarni RR, Weldon WC, Silveira ELV, Ahmed H, Gunisetty S, Chandele A, Antia R, Verma H, Sutter R, Pallansch MA, Oberste MS, Villinger F, Orenstein W, Murali-Krishna K. Bhaumik SK, et al. Among authors: villinger f. Clin Infect Dis. 2018 Oct 30;67(suppl_1):S66-S77. doi: 10.1093/cid/ciy634. Clin Infect Dis. 2018. PMID: 30376091 Free PMC article.
BACKGROUND: As a risk-mitigation strategy to minimize paralytic polio following withdrawal of Sabin type 2 from the oral poliovirus vaccine in April 2016, a single full dose or 2 fractional doses of inactivated poliovirus vaccine (IPV) are recommended. However, limited knowledge …
BACKGROUND: As a risk-mitigation strategy to minimize paralytic polio following withdrawal of Sabin type 2 from the oral poliovirus vaccine …
CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection.
Kwa S, Sadagopal S, Shen X, Hong JJ, Gangadhara S, Basu R, Victor B, Iyer SS, LaBranche CC, Montefiori DC, Tomaras GD, Villinger F, Moss B, Kozlowski PA, Amara RR. Kwa S, et al. Among authors: villinger f. J Virol. 2015 Apr;89(8):4690-5. doi: 10.1128/JVI.03527-14. Epub 2015 Feb 4. J Virol. 2015. PMID: 25653428 Free PMC article.
Here, we show that a CD40L-adjuvanted DNA/modified vaccinia virus Ankara (MVA) simian immunodeficiency virus (SIV) vaccine enhances protection against a pathogenic neutralization-resistant mucosal SIV infection, improves long-term viral control, and prevents AIDS. Analyses …
Here, we show that a CD40L-adjuvanted DNA/modified vaccinia virus Ankara (MVA) simian immunodeficiency virus (SIV) vaccine enhances protecti …
Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21.
Pallikkuth S, Micci L, Ende ZS, Iriele RI, Cervasi B, Lawson B, McGary CS, Rogers KA, Else JG, Silvestri G, Easley K, Estes JD, Villinger F, Pahwa S, Paiardini M. Pallikkuth S, et al. Among authors: villinger f. PLoS Pathog. 2013;9(7):e1003471. doi: 10.1371/journal.ppat.1003471. Epub 2013 Jul 4. PLoS Pathog. 2013. PMID: 23853592 Free PMC article.
Interleukin (IL)-21 promotes differentiation of Th17 cells, long-term maintenance of functional CD8+ T cells, and differentiation of memory B cells and antibody-secreting plasma cells. ...
Interleukin (IL)-21 promotes differentiation of Th17 cells, long-term maintenance of functional CD8+ T cells, and differentiation of …
High-level, lasting antiviral immunity induced by a bimodal AIDS vaccine and boosted by live-virus exposure: prevention of viremia.
Rasmussen RA, Siddappa NB, Lakhashe SK, Watkins J, Villinger F, Ibegbu C, Florese RH, Robert-Guroff M, Montefiori DC, Forthal DN, O'Connor D, Ruprecht RM; Clade C Program Project Group. Rasmussen RA, et al. Among authors: villinger f. AIDS. 2012 Jan 14;26(2):149-55. doi: 10.1097/QAD.0b013e32834d3c4f. AIDS. 2012. PMID: 21941166 Free PMC article.
METHODS: Long-term immune reactivity was evaluated and identification of virus in RAt-9 was attempted by RT-PCR analysis of concentrated plasma and blood transfer to CD8(+) cell-depleted infant macaques. ...CONCLUSION: Monkey RAt-9 is the first example of a virus-exposed, …
METHODS: Long-term immune reactivity was evaluated and identification of virus in RAt-9 was attempted by RT-PCR analysis of concentra …
Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits.
Ali Z, Yan L, Plagman N, Reichenberg A, Hintz M, Jomaa H, Villinger F, Chen ZW. Ali Z, et al. Among authors: villinger f. J Immunol. 2009 Oct 15;183(8):5407-17. doi: 10.4049/jimmunol.0901760. Epub 2009 Sep 28. J Immunol. 2009. PMID: 19786533 Free PMC article.
Such increases in Abs were sustained for >170 days and were immediately preceded by increased production of IFN-gamma, TNF-alpha, IL-4, and IL-10 during peak expansion of Vgamma2Vdelta2 T cells displaying memory phenotypes, as well as the short-term increased effector f …
Such increases in Abs were sustained for >170 days and were immediately preceded by increased production of IFN-gamma, TNF-alpha, IL-4, a …
The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates.
Ansari AA, Pereira LE, Mayne AE, Onlamoon N, Pattanapanyasat K, Mori K, Villinger F. Ansari AA, et al. Among authors: villinger f. J Autoimmun. 2007 Mar-May;28(2-3):152-9. doi: 10.1016/j.jaut.2007.02.014. Epub 2007 Mar 26. J Autoimmun. 2007. PMID: 17368846 Free PMC article. Review.
Results of these studies showed that the highest autoantibody titers were noted in animals with lower relative plasma viral loads with a wider spectrum of autoantigens that are the target of such responses as compared with lower autoantibody titers in animals with relatively high …
Results of these studies showed that the highest autoantibody titers were noted in animals with lower relative plasma viral loads with a wid …
Studies on GM-CSF DNA as an adjuvant for neutralizing Ab elicited by a DNA/MVA immunodeficiency virus vaccine.
Robinson HL, Montefiori DC, Villinger F, Robinson JE, Sharma S, Wyatt LS, Earl PL, McClure HM, Moss B, Amara RR. Robinson HL, et al. Among authors: villinger f. Virology. 2006 Sep 1;352(2):285-94. doi: 10.1016/j.virol.2006.02.011. Epub 2006 Jun 5. Virology. 2006. PMID: 16740288 Free article.
Co-delivery of GM-CSF and vaccine DNAs enhanced the temporal appearance of neutralizing Ab and broadened the specificity of the neutralizing activity to include SHIV-89.6P. Two long-term SHIV-89.6 infections elicited neutralizing activity for SHIV-89.6 but not SHIV-89.6P. …
Co-delivery of GM-CSF and vaccine DNAs enhanced the temporal appearance of neutralizing Ab and broadened the specificity of the neutralizing …
Ancient co-speciation of simian foamy viruses and primates.
Switzer WM, Salemi M, Shanmugam V, Gao F, Cong ME, Kuiken C, Bhullar V, Beer BE, Vallet D, Gautier-Hion A, Tooze Z, Villinger F, Holmes EC, Heneine W. Switzer WM, et al. Among authors: villinger f. Nature. 2005 Mar 17;434(7031):376-80. doi: 10.1038/nature03341. Nature. 2005. PMID: 15772660
Although parasite-host co-speciation is a long-held hypothesis, convincing evidence for long-term co-speciation remains elusive, largely because of small numbers of hosts and parasites studied and uncertainty over rates of evolutionary change. ...
Although parasite-host co-speciation is a long-held hypothesis, convincing evidence for long-term co-speciation remains elusive, larg …
17 results