Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo.
Samer S, Thomas Y, Araínga M, Carter C, Shirreff LM, Arif MS, Avita JM, Frank I, McRaven MD, Thuruthiyil CT, Heybeli VB, Anderson MR, Owen B, Gaisin A, Bose D, Simons LM, Hultquist JF, Arthos J, Cicala C, Sereti I, Santangelo PJ, Lorenzo-Redondo R, Hope TJ, Villinger FJ, Martinelli E.
Samer S, et al. Among authors: villinger fj.
JCI Insight. 2022 Nov 8;7(21):e162290. doi: 10.1172/jci.insight.162290.
JCI Insight. 2022.
PMID: 36125890
Free PMC article.
Resting HIV-1 target cells represent the main cellular reservoir after long-term antiretroviral therapy (ART). We hypothesized that releasing cells from TGF-beta-driven signaling would promote latency reversal. ...In vivo, oral galunisertib promoted increased total standar …
Resting HIV-1 target cells represent the main cellular reservoir after long-term antiretroviral therapy (ART). We hypothesized that r …