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Page 1
Regulation of the oxidative balance with coenzyme Q10 sensitizes human glioblastoma cells to radiation and temozolomide.
Frontiñán-Rubio J, Santiago-Mora RM, Nieva-Velasco CM, Ferrín G, Martínez-González A, Gómez MV, Moreno M, Ariza J, Lozano E, Arjona-Gutiérrez J, Gil-Agudo A, De la Mata M, Pesic M, Peinado JR, Villalba JM, Pérez-Romasanta L, Pérez-García VM, Alcaín FJ, Durán-Prado M. Frontiñán-Rubio J, et al. Among authors: villalba jm. Radiother Oncol. 2018 Aug;128(2):236-244. doi: 10.1016/j.radonc.2018.04.033. Epub 2018 May 18. Radiother Oncol. 2018. PMID: 29784452 Free article.
CoQ-treated cells were twofold more sensitive than control to radiation-induced DNA damage and apoptosis in short and long-term clonogenic assays, potentiating TMZ-induced cytotoxicity, without affecting non-transformed astrocytes. ...
CoQ-treated cells were twofold more sensitive than control to radiation-induced DNA damage and apoptosis in short and long-term clono …
Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile: A Randomized, Placebo-Controlled Trial.
Pérez-Sánchez C, Aguirre MÁ, Ruiz-Limón P, Ábalos-Aguilera MC, Jiménez-Gómez Y, Arias-de la Rosa I, Rodriguez-Ariza A, Fernández-Del Río L, González-Reyes JA, Segui P, Collantes-Estévez E, Barbarroja N, Velasco F, Sciascia S, Cecchi I, Cuadrado MJ, Villalba JM, López-Pedrera C. Pérez-Sánchez C, et al. Among authors: villalba jm. Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1923-1932. doi: 10.1161/ATVBAHA.117.309225. Epub 2017 Jul 6. Arterioscler Thromb Vasc Biol. 2017. PMID: 28684614 Free article. Clinical Trial.
This disturbance is related to the patients' prothrombotic status and can be prevented by in vitro treatment with coenzyme Q10. Our aim was to investigate short-term effects of in vivo ubiquinol (reduced coenzyme Q(10) [Q(red)]) supplementation on markers related to inflam …
This disturbance is related to the patients' prothrombotic status and can be prevented by in vitro treatment with coenzyme Q10. Our aim was …
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.
Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R. Mercken EM, et al. Among authors: villalba jm. Aging Cell. 2014 Oct;13(5):787-96. doi: 10.1111/acel.12220. Epub 2014 Jun 16. Aging Cell. 2014. PMID: 24931715 Free PMC article.
This is accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensitivity associated with higher mitochondrial content and decreased inflammation. Short-term SRT2104 treatment preserves bone and muscle …
This is accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensiti …
Dicoumarol relieves serum withdrawal-induced G0/1 blockade in HL-60 cells through a superoxide-dependent mechanism.
Bello RI, Gómez-Díaz C, López-Lluch G, Forthoffer N, Córdoba-Pedregosa MC, Navas P, Villalba JM. Bello RI, et al. Among authors: villalba jm. Biochem Pharmacol. 2005 Jun 1;69(11):1613-25. doi: 10.1016/j.bcp.2005.03.012. Epub 2005 Apr 18. Biochem Pharmacol. 2005. PMID: 15896341
Inhibition of G0/1 blockade was confirmed by the increase of thymidine incorporation, the phosphorylation of retinoblastoma protein, and the promotion of cell growth in long-term treatments in the absence of serum. Dicoumarol treatment increased superoxide levels, but did …
Inhibition of G0/1 blockade was confirmed by the increase of thymidine incorporation, the phosphorylation of retinoblastoma protein, and the …
Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal.
Barroso MP, Gómez-Díaz C, Villalba JM, Burón MI, López-Lluch G, Navas P. Barroso MP, et al. Among authors: villalba jm. J Bioenerg Biomembr. 1997 Jun;29(3):259-67. doi: 10.1023/a:1022462111175. J Bioenerg Biomembr. 1997. PMID: 9298711
HL-60 cells were sensitive to serum removal, and an increase of lipid peroxidation and apoptosis was observed. Long-term treatment with ethidium bromide induced the mitochondria-deficient rho(o)HL-60 cell line. ...
HL-60 cells were sensitive to serum removal, and an increase of lipid peroxidation and apoptosis was observed. Long-term treatment wi …
Ascorbate stabilization is stimulated in rho(0)HL-60 cells by CoQ10 increase at the plasma membrane.
Gómez-Díaz C, Villalba JM, Pérez-Vicente R, Crane FL, Navas P. Gómez-Díaz C, et al. Among authors: villalba jm. Biochem Biophys Res Commun. 1997 May 8;234(1):79-81. doi: 10.1006/bbrc.1997.6582. Biochem Biophys Res Commun. 1997. PMID: 9168964
Long-term treatment with ethidium bromide of HL-60 cells induced a mitochondria-deficient rho degree cell line, where mitochondrial DNA can not be identified by PCR and cytochrome c oxidase activity was 80% decreased. ...
Long-term treatment with ethidium bromide of HL-60 cells induced a mitochondria-deficient rho degree cell line, where mitochondrial D …
Cyclic AMP-plus ATP-dependent modulation of the NADH oxidase activity of porcine liver plasma membranes.
Morré DJ, Navas P, Rodriguez-Aguilera JC, Morré DM, Villalba JM, de Cabo R, Lawrence J. Morré DJ, et al. Among authors: villalba jm. Biochim Biophys Acta. 1994 Dec 30;1224(3):566-74. doi: 10.1016/0167-4889(94)90295-x. Biochim Biophys Acta. 1994. PMID: 7803517
The oxidation was resistant to cyanide and responded to nanomolar concentrations of ATP alone or ATP in the presence of cyclic AMP. Both the Km for NADH and the long-term activity of the oxidase were affected. Upon incubation at 37 degrees C with cyclic AMP (0.1-10 nM) and …
The oxidation was resistant to cyanide and responded to nanomolar concentrations of ATP alone or ATP in the presence of cyclic AMP. Both the …
Transplasma membrane redox system of HL-60 cells is controlled by cAMP.
Rodríguez-Aguilera JC, Nakayama K, Arroyo A, Villalba JM, Navas P. Rodríguez-Aguilera JC, et al. Among authors: villalba jm. J Biol Chem. 1993 Dec 15;268(35):26346-9. J Biol Chem. 1993. PMID: 8253758 Free article.
Lactate slightly affected the ascorbate regeneration in nonstimulated cells, but showed a significant effect on Sp-cAMP-S-stimulated plasma membrane electron flow. We show here a role for cAMP in the short-term modulation of transplasma membrane redox system measured as th …
Lactate slightly affected the ascorbate regeneration in nonstimulated cells, but showed a significant effect on Sp-cAMP-S-stimulated plasma …
Ascorbate is regenerated by HL-60 cells through the transplasmalemma redox system.
Alcain FJ, Buron MI, Villalba JM, Navas P. Alcain FJ, et al. Among authors: villalba jm. Biochim Biophys Acta. 1991 Mar 4;1073(2):380-5. doi: 10.1016/0304-4165(91)90146-8. Biochim Biophys Acta. 1991. PMID: 2009284
Ascorbate was maintained in the media during a long-term culture by HL-60 cells. The chemical oxidation of ascorbate was reversed in vitro by living HL-60 cells and was related to the amount of cells added. ...
Ascorbate was maintained in the media during a long-term culture by HL-60 cells. The chemical oxidation of ascorbate was reversed in …
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