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Early sclerostin assessment in frail elderly patients with sepsis: insights on short- and long-term mortality prediction.
Tirandi A, Arboscello E, Ministrini S, Liberale L, Bonaventura A, Vecchié A, Bertolotto M, Giacobbe DR, Castellani L, Mirabella M, Minetti S, Bassetti M, Montecucco F, Carbone F. Tirandi A, et al. Among authors: vecchie a. Intern Emerg Med. 2023 Aug;18(5):1509-1519. doi: 10.1007/s11739-023-03223-w. Epub 2023 Mar 21. Intern Emerg Med. 2023. PMID: 36943596 Free PMC article.
Thirty-day mortality was set as primary outcome. In-hospital and long-term mortality (2.5 years of median follow-up) were assessed as secondary outcomes. ...The degree of this variation further predicted long-term mortality (HR for delta SOST T0-day 14: 1.006 with 9 …
Thirty-day mortality was set as primary outcome. In-hospital and long-term mortality (2.5 years of median follow-up) were assessed as …
Acute Effects of Liothyronine Administration on Cardiovascular System and Energy Metabolism in Healthy Volunteers.
Chen S, Wohlford GF, Vecchie' A, Carbone S, Yavuz S, Van Tassell B, Abbate A, Celi FS. Chen S, et al. Among authors: vecchie a. Front Endocrinol (Lausanne). 2022 Feb 28;13:843539. doi: 10.3389/fendo.2022.843539. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35295986 Free PMC article. Clinical Trial.
CONCLUSIONS: The absence of measurable rapid effects on the cardiovascular system following a high dose of liothyronine supports the rationale to perform long-term studies to assess its safety and effectiveness in patients affected by hypothyroidism....
CONCLUSIONS: The absence of measurable rapid effects on the cardiovascular system following a high dose of liothyronine supports the rationa …
Orthostatic intolerance syndromes after hematopoietic cell transplantation: clinical characteristics and therapeutic interventions in a single-center experience.
Vecchié A, Thomas G, Bressi E, Bonaventura A, Canada JM, Chuquin D, Kadariya D, Piracha U, Endicott D, Markley R, Toor A, Hess M, Abbate A. Vecchié A, et al. Cardiooncology. 2021 Nov 30;7(1):40. doi: 10.1186/s40959-021-00126-7. Cardiooncology. 2021. PMID: 34847948 Free PMC article.
BACKGROUND: Hematopoietic cell transplantation (HCT) is an established and potentially curative therapeutic option for hematologic cancers. HCT survivors are at risk of developing long-term complications impacting on morbidity and mortality. Orthostatic hypotension (OH) an …
BACKGROUND: Hematopoietic cell transplantation (HCT) is an established and potentially curative therapeutic option for hematologic cancers. …
Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19.
Bonaventura A, Vecchié A, Dagna L, Martinod K, Dixon DL, Van Tassell BW, Dentali F, Montecucco F, Massberg S, Levi M, Abbate A. Bonaventura A, et al. Among authors: vecchie a. Nat Rev Immunol. 2021 May;21(5):319-329. doi: 10.1038/s41577-021-00536-9. Epub 2021 Apr 6. Nat Rev Immunol. 2021. PMID: 33824483 Free PMC article. Review.
The growing understanding of SARS-CoV-2 infection pathogenesis and how it contributes to critical illness and its complications may help to improve risk stratification and develop targeted therapies to reduce the acute and long-term consequences of this disease....
The growing understanding of SARS-CoV-2 infection pathogenesis and how it contributes to critical illness and its complications may help to …
Cardiology on the cutting edge: updates from the European Society of Cardiology (ESC) Congress 2020.
Gallego-Colon E, Bonaventura A, Vecchié A, Cannatà A, Fitzpatrick CM. Gallego-Colon E, et al. Among authors: vecchie a. BMC Cardiovasc Disord. 2020 Oct 19;20(1):448. doi: 10.1186/s12872-020-01734-4. BMC Cardiovasc Disord. 2020. PMID: 33070781 Free PMC article.
To conclude, an important take-home message for all CV health care professionals engaged in the COVID-19 pandemic is that we must foresee and be prepared to tackle the dramatic, long-term CV complications of COVID-19 patients....
To conclude, an important take-home message for all CV health care professionals engaged in the COVID-19 pandemic is that we must foresee an …
The effects of canagliflozin compared to sitagliptin on cardiorespiratory fitness in type 2 diabetes mellitus and heart failure with reduced ejection fraction: The CANA-HF study.
Carbone S, Billingsley HE, Canada JM, Bressi E, Rotelli B, Kadariya D, Dixon DL, Markley R, Trankle CR, Cooke R, Rao K, B Shah K, Medina de Chazal H, Chiabrando JG, Vecchié A, Dell M, L Mihalick V, Bogaev R, Hart L, Van Tassell BW, Arena R, Celi FS, Abbate A. Carbone S, et al. Among authors: vecchie a. Diabetes Metab Res Rev. 2020 Nov;36(8):e3335. doi: 10.1002/dmrr.3335. Epub 2020 Jun 15. Diabetes Metab Res Rev. 2020. PMID: 32415802 Free PMC article. Clinical Trial.
Canagliflozin also reduced MLHFQ score (-12.1, P = .018). CONCLUSIONS: In this small and short-term study of patients with T2DM and HFrEF, interrupted early after only 36 patients, canagliflozin did not improve the primary endpoints of peak VO(2) or VE/VCO(2) slope compare …
Canagliflozin also reduced MLHFQ score (-12.1, P = .018). CONCLUSIONS: In this small and short-term study of patients with T2DM and H …
Management of Acute and Recurrent Pericarditis: JACC State-of-the-Art Review.
Chiabrando JG, Bonaventura A, Vecchié A, Wohlford GF, Mauro AG, Jordan JH, Grizzard JD, Montecucco F, Berrocal DH, Brucato A, Imazio M, Abbate A. Chiabrando JG, et al. Among authors: vecchie a. J Am Coll Cardiol. 2020 Jan 7;75(1):76-92. doi: 10.1016/j.jacc.2019.11.021. J Am Coll Cardiol. 2020. PMID: 31918837 Free article. Review.
Acute pericarditis is generally self-limited and not life-threatening; yet, it may cause significant short-term disability, be complicated by either a large pericardial effusion or tamponade, and carry a significant risk of recurrence. ...
Acute pericarditis is generally self-limited and not life-threatening; yet, it may cause significant short-term disability, be compli …
Baseline neutrophil-to-lymphocyte ratio is associated with long-term T2D remission after metabolic surgery.
Bonaventura A, Liberale L, Carbone F, Vecchié A, Bonomi A, Scopinaro N, Camerini GB, Papadia FS, Maggi D, Cordera R, Dallegri F, Adami G, Montecucco F. Bonaventura A, et al. Among authors: vecchie a. Acta Diabetol. 2019 Jul;56(7):741-748. doi: 10.1007/s00592-019-01345-2. Epub 2019 Apr 16. Acta Diabetol. 2019. PMID: 30993529
In order to identify novel laboratory variables that could improve the selection of patients who might greatly benefit from a surgical approach, we focused on the neutrophil-to-lymphocyte ratio (NLR) as a predictor of long-term T2D remission following metabolic surgery. ME …
In order to identify novel laboratory variables that could improve the selection of patients who might greatly benefit from a surgical appro …
Reduction in TIMP-2 serum levels predicts remission of inflammatory bowel diseases.
Carbone F, Bodini G, Brunacci M, Bonaventura A, Vecchiè A, Liberale L, Crespi M, Baldissarro I, Dallegri F, Savarino V, Montecucco F, Giannini EG. Carbone F, et al. Among authors: vecchie a. Eur J Clin Invest. 2018 Oct;48(10):e13002. doi: 10.1111/eci.13002. Epub 2018 Aug 6. Eur J Clin Invest. 2018. PMID: 30011062
Conversely, no other change in inflammatory molecule concentrations was able to predict short- or long-term IBD remission. CONCLUSIONS: This study indicates TIMP-2 reduction during IBD treatment with monoclonal anti-TNF-alpha antibodies as a potential prognostic parameter …
Conversely, no other change in inflammatory molecule concentrations was able to predict short- or long-term IBD remission. CONCLUSION …
Update on Inflammatory Biomarkers and Treatments in Ischemic Stroke.
Bonaventura A, Liberale L, Vecchié A, Casula M, Carbone F, Dallegri F, Montecucco F. Bonaventura A, et al. Among authors: vecchie a. Int J Mol Sci. 2016 Nov 25;17(12):1967. doi: 10.3390/ijms17121967. Int J Mol Sci. 2016. PMID: 27898011 Free PMC article. Review.
New therapies appear promising both in pre-clinical and clinical studies, but still need more detailed studies to be translated in the ordinary clinical practice. In spite of clinical progresses, no beneficial long-term interventions targeting inflammation are currently av …
New therapies appear promising both in pre-clinical and clinical studies, but still need more detailed studies to be translated in the ordin …