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An anti-CD19/CTLA-4 switch improves efficacy and selectivity of CAR T cells targeting CD80/86-upregulated DLBCL.
Prinz LF, Riet T, Neureuther DF, Lennartz S, Chrobok D, Hübbe H, Uhl G, Riet N, Hofmann P, Hösel M, Simon AG, Tetenborg L, Segbers P, Shimono J, Gödel P, Balke-Want H, Flümann R, Knittel G, Reinhardt HC, Scheid C, Büttner R, Chapuy B, Ullrich RT, Hallek M, Chmielewski MM. Prinz LF, et al. Among authors: ullrich rt. Cell Rep Med. 2024 Feb 20;5(2):101421. doi: 10.1016/j.xcrm.2024.101421. Epub 2024 Feb 9. Cell Rep Med. 2024. PMID: 38340727 Free PMC article.
CAR/CCR T cells demonstrate superior efficacy in xenograft mouse models compared with CAR T cells, superior long-term activity, and superior selectivity in in vitro assays with non-malignant CD19(+) cells. ...
CAR/CCR T cells demonstrate superior efficacy in xenograft mouse models compared with CAR T cells, superior long-term activity, and s …
A multi-country analysis of COVID-19 hospitalizations by vaccination status.
Gonçalves BP, Jassat W, Baruch J, Hashmi M, Rojek A, Dasgupta A, Martin-Loeches I, Reyes LF, Piubelli C, Citarella BW, Kartsonaki C, Lefèvre B, López Revilla JW, Lunn M, Harrison EM, Kraemer MUG, Shrapnel S, Horby P, Bisoffi Z, Olliaro PL, Merson L; ISARIC Clinical Characterisation Group. Gonçalves BP, et al. Med. 2023 Nov 10;4(11):797-812.e2. doi: 10.1016/j.medj.2023.08.005. Epub 2023 Sep 21. Med. 2023. PMID: 37738979 Free PMC article.
CONCLUSIONS: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history. ...
CONCLUSIONS: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term internat …
Intravenous IgM-enriched immunoglobulins in critical COVID-19: a multicentre propensity-weighted cohort study.
Rahmel T, Kraft F, Haberl H, Achtzehn U, Brandenburger T, Neb H, Jarczak D, Dietrich M, Magunia H, Zimmer F, Basten J, Landgraf C, Koch T, Zacharowski K, Weigand MA, Rosenberger P, Ullrich R, Meybohm P, Nierhaus A, Kindgen-Milles D, Timmesfeld N, Adamzik M. Rahmel T, et al. Among authors: ullrich r. Crit Care. 2022 Jul 7;26(1):204. doi: 10.1186/s13054-022-04059-0. Crit Care. 2022. PMID: 35799196 Free PMC article.
BACKGROUND: A profound inflammation-mediated lung injury with long-term acute respiratory distress and high mortality is one of the major complications of critical COVID-19. ...
BACKGROUND: A profound inflammation-mediated lung injury with long-term acute respiratory distress and high mortality is one of the m …
Cerebral microemboli during extracorporeal life support: a single-centre cohort study.
Kietaibl C, Horvat Menih I, Engel A, Ullrich R, Klein KU, Erdoes G. Kietaibl C, et al. Among authors: ullrich r. Eur J Cardiothorac Surg. 2021 Dec 27;61(1):172-179. doi: 10.1093/ejcts/ezab353. Eur J Cardiothorac Surg. 2021. PMID: 34406372
CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT02020759, https://clinicaltrials.gov/ct2/show/NCT02020759?term=erdoes&rank=1....
CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT02020759, https://clinicaltrials.gov/ct2/show/NCT02020759?term=erdoes&rank=1. …
Effects of Low Dose Space Radiation Exposures on the Splenic Metabolome.
Laiakis EC, Shuryak I, Deziel A, Wang YW, Barnette BL, Yu Y, Ullrich RL, Fornace AJ Jr, Emmett MR. Laiakis EC, et al. Among authors: ullrich rl. Int J Mol Sci. 2021 Mar 17;22(6):3070. doi: 10.3390/ijms22063070. Int J Mol Sci. 2021. PMID: 33802822 Free PMC article.
Taken together, there is a strong suggestion of mitochondrial implication and the possibility of long-term effects on DNA repair and nucleotide pools following radiation exposure....
Taken together, there is a strong suggestion of mitochondrial implication and the possibility of long-term effects on DNA repair and …
Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo.
Mittenbühler MJ, Saedler K, Nolte H, Kern L, Zhou J, Qian SB, Meder L, Ullrich RT, Brüning JC, Wunderlich FT. Mittenbühler MJ, et al. Among authors: ullrich rt. Mol Metab. 2020 Dec;42:101085. doi: 10.1016/j.molmet.2020.101085. Epub 2020 Sep 19. Mol Metab. 2020. PMID: 32956847 Free PMC article.
To determine the impact of hepatic FTO on HCC development, FTO(L-KO) and Ctrl mice were subjected to long-term diethylnitrosamine (DEN)-induced HCC-development and the tumor initiation phase was examined via a short-term DEN protocol. RESULTS: In long-term DE …
To determine the impact of hepatic FTO on HCC development, FTO(L-KO) and Ctrl mice were subjected to long-term diethylnitrosamine (DE …
Disseminating Intention: How a term has spread within cross-species comparative science.
Ullrich R, Mittelbach M, Liebal K. Ullrich R, et al. J Comp Psychol. 2020 Feb;134(1):11-26. doi: 10.1037/com0000191. Epub 2019 Jul 22. J Comp Psychol. 2020. PMID: 31328953
The current study takes a holistic view of cross-species comparative research and investigates the dissemination of the term intention as representative of the so-called "cognitive revolution." ...Furthermore, taking account of which species are investigated could reveal a …
The current study takes a holistic view of cross-species comparative research and investigates the dissemination of the term intentio …
Estimation of liver fibrosis by noncommercial serum markers in comparison with transient elastography in patients with chronic hepatitis C virus infection receiving direct-acting antiviral treatment.
Knop V, Hofmann WP, Buggisch P, Klinker H, Mauss S, Günther R, Hinrichsen H, Hüppe D, Pfeiffer-Vornkahl H, Simon KG, Berg T, Manns MP, Friedrich-Rust M; German Hepatitis C-Registry. Knop V, et al. J Viral Hepat. 2019 Feb;26(2):224-230. doi: 10.1111/jvh.13021. Epub 2018 Nov 8. J Viral Hepat. 2019. PMID: 30315694
In conclusion, in the present multicentre real-world cohort, SF and cirrhosis were predicted with high accuracy with noncommercial serum markers using TE as reference. Further prospective long-term follow-up is necessary to compare biomarkers with TE concerning liver-relat …
In conclusion, in the present multicentre real-world cohort, SF and cirrhosis were predicted with high accuracy with noncommercial serum mar …
Long-term response to gluten-free diet as evidence for non-celiac wheat sensitivity in one third of patients with diarrhea-dominant and mixed-type irritable bowel syndrome.
Barmeyer C, Schumann M, Meyer T, Zielinski C, Zuberbier T, Siegmund B, Schulzke JD, Daum S, Ullrich R. Barmeyer C, et al. Among authors: ullrich r. Int J Colorectal Dis. 2017 Jan;32(1):29-39. doi: 10.1007/s00384-016-2663-x. Epub 2016 Sep 30. Int J Colorectal Dis. 2017. PMID: 27695975 Free PMC article.
Based on the hypothesis of non-celiac wheat sensitivity (WS) in a subgroup of IBS patients, we tested the long-term response to a gluten-free diet (GFD) and investigated HLA-DQ2 or -DQ8 expression as a diagnostic marker for WS in diarrhea-dominant (IBS-D) and mixed-type IB …
Based on the hypothesis of non-celiac wheat sensitivity (WS) in a subgroup of IBS patients, we tested the long-term response to a glu …
Space radiation-associated lung injury in a murine model.
Christofidou-Solomidou M, Pietrofesa RA, Arguiri E, Schweitzer KS, Berdyshev EV, McCarthy M, Corbitt A, Alwood JS, Yu Y, Globus RK, Solomides CC, Ullrich RL, Petrache I. Christofidou-Solomidou M, et al. Among authors: ullrich rl. Am J Physiol Lung Cell Mol Physiol. 2015 Mar 1;308(5):L416-28. doi: 10.1152/ajplung.00260.2014. Epub 2014 Dec 19. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25526737 Free PMC article.
Despite considerable progress in identifying health risks to crewmembers related to exposure to galactic/cosmic rays and solar particle events (SPE) during space travel, its long-term effects on the pulmonary system are unknown. We used a murine risk projection model to in …
Despite considerable progress in identifying health risks to crewmembers related to exposure to galactic/cosmic rays and solar particle even …
33 results