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2013 6
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65 results

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A unified mediation analysis framework for integrative cancer proteogenomics with clinical outcomes.
Huang L, Long JP, Irajizad E, Doecke JD, Do KA, Ha MJ. Huang L, et al. Bioinformatics. 2023 Jan 1;39(1):btad023. doi: 10.1093/bioinformatics/btad023. Bioinformatics. 2023. PMID: 36648331 Free PMC article.
Using kidney renal clear cell carcinoma proteogenomic data, we identify genes that are mediated by proteins and the underlying mechanisms on various survival outcomes that capture short- and long-term disease-specific clinical characteristics. AVAILABILITY AND IMPLEMENTATI …
Using kidney renal clear cell carcinoma proteogenomic data, we identify genes that are mediated by proteins and the underlying mechanisms on …
Outcomes of the Second Aqueous Shunt Implant Versus Transscleral Cyclophotocoagulation Treatment Study: A Randomized Comparative Trial.
Feldman RM, Chuang AZ, Mansberger SL, Tanna AP, Blieden LS, Bell NP, Gross RL, Pasquale LR, Greenfield DS, Liebmann JM, Weinreb RN; ASSISTS Group. Feldman RM, et al. J Glaucoma. 2022 Sep 1;31(9):701-709. doi: 10.1097/IJG.0000000000002079. Epub 2022 Jul 21. J Glaucoma. 2022. PMID: 35901309 Free PMC article. Clinical Trial.
PRCIS: Short-term overall success rates were high with either SGDD or CPC. However, SGDD was associated with more clinic visits and an increased risk of additional glaucoma surgery. ...The number of additional glaucoma surgeries ( P =0.003), office visits during the first …
PRCIS: Short-term overall success rates were high with either SGDD or CPC. However, SGDD was associated with more clinic visits and a …
Dabrafenib plus trametinib in patients with BRAF V600E-mutant anaplastic thyroid cancer: updated analysis from the phase II ROAR basket study.
Subbiah V, Kreitman RJ, Wainberg ZA, Cho JY, Schellens JHM, Soria JC, Wen PY, Zielinski CC, Cabanillas ME, Boran A, Ilankumaran P, Burgess P, Romero Salas T, Keam B. Subbiah V, et al. Ann Oncol. 2022 Apr;33(4):406-415. doi: 10.1016/j.annonc.2021.12.014. Epub 2022 Jan 10. Ann Oncol. 2022. PMID: 35026411 Free PMC article. Clinical Trial.
CONCLUSIONS: These updated results confirm the substantial clinical benefit and manageable toxicity of dabrafenib plus trametinib in BRAF V600E-mutant ATC. Dabrafenib plus trametinib notably improved long-term survival and represents a meaningful treatment option for this …
CONCLUSIONS: These updated results confirm the substantial clinical benefit and manageable toxicity of dabrafenib plus trametinib in BRAF V6 …
Long-Term Cognitive Impairment Associated With Delirium in Acute Neurological Injury.
Meeks JR, Bambhroliya AB, Sheth SA, Khan B, Slooter AJC, Ely EW, Miller CC, Tyson JE, McCullough LD, Savitz SI, Vahidy FS. Meeks JR, et al. Crit Care Explor. 2020 Jun 9;2(6):e0130. doi: 10.1097/CCE.0000000000000130. eCollection 2020 Jun. Crit Care Explor. 2020. PMID: 32695995 Free PMC article.
OBJECTIVES: To characterize the risk of long-term cognitive impairment associated with delirium in acute neurologic injury patients. ...CONCLUSIONS: Identification, management, and prevention of in-hospital delirium could potentially improve long-term cognitive outc …
OBJECTIVES: To characterize the risk of long-term cognitive impairment associated with delirium in acute neurologic injury patients. …
Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies.
Yang RK, Qing Y, Jelloul FZ, Routbort MJ, Wang P, Shaw K, Zhang J, Lee J, Medeiros LJ, Kopetz S, Tetzlaff MT, Broaddus RR. Yang RK, et al. Oncotarget. 2020 Feb 11;11(6):600-618. doi: 10.18632/oncotarget.27466. eCollection 2020 Feb 11. Oncotarget. 2020. PMID: 32110280 Free PMC article.
Multivariate regression analysis including the two variables of tumor mutation burden (TMB) and ICB, and their interaction term, showed favorable survival associated with ICB, unfavorable survival associated with TMB without ICB treatment, and improved outcome with increas …
Multivariate regression analysis including the two variables of tumor mutation burden (TMB) and ICB, and their interaction term, show …
Advances in Targeting RET-Dependent Cancers.
Subbiah V, Cote GJ. Subbiah V, et al. Cancer Discov. 2020 Apr;10(4):498-505. doi: 10.1158/2159-8290.CD-19-1116. Epub 2020 Feb 24. Cancer Discov. 2020. PMID: 32094155 Free PMC article. Review.
Questions that clearly need to be addressed relate to the ability to maintain long-term inhibition of tumor cell growth, how to prepare for the potential mechanisms of acquired resistance, and the development of next-generation selective RET inhibitors....
Questions that clearly need to be addressed relate to the ability to maintain long-term inhibition of tumor cell growth, how to prepa …
Early Detection of Cerebral Palsy Using Sensorimotor Tract Biomarkers in Very Preterm Infants.
Parikh NA, Hershey A, Altaye M. Parikh NA, et al. Pediatr Neurol. 2019 Sep;98:53-60. doi: 10.1016/j.pediatrneurol.2019.05.001. Epub 2019 May 9. Pediatr Neurol. 2019. PMID: 31201071 Free PMC article.
BACKGROUND: Our objectives were to evaluate the brain's sensorimotor network microstructure using diffusion magnetic resonance imaging (MRI) at term-corrected age and test the ability of sensorimotor microstructural parameters to accurately predict cerebral palsy in extrem …
BACKGROUND: Our objectives were to evaluate the brain's sensorimotor network microstructure using diffusion magnetic resonance imaging (MRI) …
Cognitive deficits in acute mild ischemic stroke and TIA and effects of rt-PA.
Rosenbaum Halevi D, Bursaw AW, Karamchandani RR, Alderman SE, Breier JI, Vahidy FS, Aden JK, Cai C, Zhang X, Savitz SI. Rosenbaum Halevi D, et al. Ann Clin Transl Neurol. 2019 Jan 22;6(3):466-474. doi: 10.1002/acn3.719. eCollection 2019 Mar. Ann Clin Transl Neurol. 2019. PMID: 30911570 Free PMC article.
INTRODUCTION: It is unknown if treatment with rt-PA in mild acute ischemic stroke (MIS) is associated with improvement in long term cognition. METHODS: Forty-five patients with suspected acute mild stroke or transient ischemic attacks with NIHSS 6 were enrolled in a prospe …
INTRODUCTION: It is unknown if treatment with rt-PA in mild acute ischemic stroke (MIS) is associated with improvement in long term c …
The combined effect of physical activity and sedentary behavior on subclinical atherosclerosis: a cross-sectional study among Mexican Americans.
Walker TJ, Heredia NI, Lee M, Laing ST, Fisher-Hoch SP, McCormick JB, Reininger BM. Walker TJ, et al. BMC Public Health. 2019 Feb 6;19(1):161. doi: 10.1186/s12889-019-6439-4. BMC Public Health. 2019. PMID: 30727990 Free PMC article.
A series of multivariable regression models were used to assess study aims. An interaction term between physical activity and sedentary behavior was included in models for each respective outcome. ...
A series of multivariable regression models were used to assess study aims. An interaction term between physical activity and sedenta …
Whole Genome-Derived Tiled Peptide Arrays Detect Prediagnostic Autoantibody Signatures in Non-Small-Cell Lung Cancer.
Yan Y, Sun N, Wang H, Kobayashi M, Ladd JJ, Long JP, Lo KC, Patel J, Sullivan E, Albert T, Goodman GE, Do KA, Hanash SM. Yan Y, et al. Cancer Res. 2019 Apr 1;79(7):1549-1557. doi: 10.1158/0008-5472.CAN-18-1536. Epub 2019 Feb 5. Cancer Res. 2019. PMID: 30723114 Free PMC article. Clinical Trial.
The majority of non-small-cell lung cancer (NSCLC) cases are diagnosed at advanced stages, primarily because earlier stages of the disease are either asymptomatic or may be attributed to other causes such as infection or long-term effects from smoking. Therefore, early det …
The majority of non-small-cell lung cancer (NSCLC) cases are diagnosed at advanced stages, primarily because earlier stages of the disease a …
65 results