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Differential expression of endothelial protein C receptor (EPCR) in hematopoietic stem and multipotent progenitor cells in young and old mice.
Lin DS, Trumpp A. Lin DS, et al. Among authors: trumpp a. Cells Dev. 2023 Jun;174:203843. doi: 10.1016/j.cdev.2023.203843. Epub 2023 Apr 18. Cells Dev. 2023. PMID: 37080459
Prior studies have consistently demonstrated that EPCR expression enriches HSCs capable of long-term multilineage repopulation in both mouse and human across different hematopoietic tissues, including bone marrow (BM), fetal liver and ex vivo HSC expansion cultures. ...
Prior studies have consistently demonstrated that EPCR expression enriches HSCs capable of long-term multilineage repopulation in bot …
Leukemic stem cells and therapy resistance in acute myeloid leukemia.
Stelmach P, Trumpp A. Stelmach P, et al. Among authors: trumpp a. Haematologica. 2023 Feb 1;108(2):353-366. doi: 10.3324/haematol.2022.280800. Haematologica. 2023. PMID: 36722405 Free PMC article. Review.
The latter arises from a few therapy-resistant cells within minimal residual disease (MRD). Resistant cells with long-term self-renewal capacity that drive clonal outgrowth are referred to as leukemic stem cells (LSC). ...
The latter arises from a few therapy-resistant cells within minimal residual disease (MRD). Resistant cells with long-term self-renew …
Analysis of nonleukemic cellular subcompartments reconstructs clonal evolution of acute myeloid leukemia and identifies therapy-resistant preleukemic clones.
Saeed BR, Manta L, Raffel S, Pyl PT, Buss EC, Wang W, Eckstein V, Jauch A, Trumpp A, Huber W, Ho AD, Lutz C. Saeed BR, et al. Among authors: trumpp a. Int J Cancer. 2021 Jun 1;148(11):2825-2838. doi: 10.1002/ijc.33461. Epub 2021 Jan 18. Int J Cancer. 2021. PMID: 33411954 Free article.
This discovery may facilitate the identification of novel targets for long-term cure....
This discovery may facilitate the identification of novel targets for long-term cure....
Survival differences and associated molecular signatures of DNMT3A-mutant acute myeloid leukemia patients.
Lauber C, Correia N, Trumpp A, Rieger MA, Dolnik A, Bullinger L, Roeder I, Seifert M. Lauber C, et al. Among authors: trumpp a. Sci Rep. 2020 Jul 29;10(1):12761. doi: 10.1038/s41598-020-69691-8. Sci Rep. 2020. PMID: 32728112 Free PMC article.
The majority of DNMT3A-mutant AML patients shows fast relapse and poor survival, but also patients with long survival or long-term remission have been reported. Underlying molecular signatures and mechanisms that contribute to these survival differences are only poorly und …
The majority of DNMT3A-mutant AML patients shows fast relapse and poor survival, but also patients with long survival or long-term re …
Haematopoietic stem cells in perisinusoidal niches are protected from ageing.
Saçma M, Pospiech J, Bogeska R, de Back W, Mallm JP, Sakk V, Soller K, Marka G, Vollmer A, Karns R, Cabezas-Wallscheid N, Trumpp A, Méndez-Ferrer S, Milsom MD, Mulaw MA, Geiger H, Florian MC. Saçma M, et al. Among authors: trumpp a. Nat Cell Biol. 2019 Nov;21(11):1309-1320. doi: 10.1038/s41556-019-0418-y. Epub 2019 Nov 4. Nat Cell Biol. 2019. PMID: 31685996
However, whether ageing also affects the HSC niche, and thereby impairs its capacity to support HSC function, is still widely debated. Here, by using in-vivo long-term label-retention assays we demonstrate that aged label-retaining HSCs, which are, in old mice, the most qu …
However, whether ageing also affects the HSC niche, and thereby impairs its capacity to support HSC function, is still widely debated. Here, …
Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo.
Hirche C, Frenz T, Haas SF, Döring M, Borst K, Tegtmeyer PK, Brizic I, Jordan S, Keyser K, Chhatbar C, Pronk E, Lin S, Messerle M, Jonjic S, Falk CS, Trumpp A, Essers MAG, Kalinke U. Hirche C, et al. Among authors: trumpp a. Cell Rep. 2017 Jun 13;19(11):2345-2356. doi: 10.1016/j.celrep.2017.05.063. Cell Rep. 2017. PMID: 28614719 Free article.
Quiescent long-term hematopoietic stem cells (LT-HSCs) are efficiently activated by type I interferon (IFN-I). ...
Quiescent long-term hematopoietic stem cells (LT-HSCs) are efficiently activated by type I interferon (IFN-I). ...
Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal.
Kanatsu-Shinohara M, Tanaka T, Ogonuki N, Ogura A, Morimoto H, Cheng PF, Eisenman RN, Trumpp A, Shinohara T. Kanatsu-Shinohara M, et al. Among authors: trumpp a. Genes Dev. 2016 Dec 1;30(23):2637-2648. doi: 10.1101/gad.287045.116. Genes Dev. 2016. PMID: 28007786 Free PMC article.
While inhibition of glycolysis decreased SSC activity, chemical stimulation of glycolysis or transfection of active Akt1 or Pdpk1 (phosphoinositide-dependent protein kinase 1 ) augmented self-renewal division, and long-term SSC cultures were derived from a nonpermissive st …
While inhibition of glycolysis decreased SSC activity, chemical stimulation of glycolysis or transfection of active Akt1 or Pdpk1 (phosphoin …
Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway.
Tesio M, Tang Y, Müdder K, Saini M, von Paleske L, Macintyre E, Pasparakis M, Waisman A, Trumpp A. Tesio M, et al. Among authors: trumpp a. J Exp Med. 2015 Apr 6;212(4):525-38. doi: 10.1084/jem.20141438. Epub 2015 Mar 30. J Exp Med. 2015. PMID: 25824820 Free PMC article.
The status of long-term quiescence and dormancy guarantees the integrity of hematopoietic stem cells (HSCs) during adult homeostasis. ...
The status of long-term quiescence and dormancy guarantees the integrity of hematopoietic stem cells (HSCs) during adult homeostasis. …
Defined conditions for the isolation and expansion of basal prostate progenitor cells of mouse and human origin.
Höfner T, Eisen C, Klein C, Rigo-Watermeier T, Goeppinger SM, Jauch A, Schoell B, Vogel V, Noll E, Weichert W, Baccelli I, Schillert A, Wagner S, Pahernik S, Sprick MR, Trumpp A. Höfner T, et al. Among authors: trumpp a. Stem Cell Reports. 2015 Mar 10;4(3):503-18. doi: 10.1016/j.stemcr.2015.01.015. Epub 2015 Feb 19. Stem Cell Reports. 2015. PMID: 25702639 Free PMC article.
Here, we present a method to grow and expand both murine and human basal PESCs long term in serum- and feeder-free conditions. The method enriches for adherent mouse basal PESCs with a Lin(-)SCA-1(+)CD49f(+)TROP2(high) phenotype. ...
Here, we present a method to grow and expand both murine and human basal PESCs long term in serum- and feeder-free conditions. The me …
The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients.
Hoang VT, Buss EC, Wang W, Hoffmann I, Raffel S, Zepeda-Moreno A, Baran N, Wuchter P, Eckstein V, Trumpp A, Jauch A, Ho AD, Lutz C. Hoang VT, et al. Among authors: trumpp a. Int J Cancer. 2015 Aug 1;137(3):525-36. doi: 10.1002/ijc.29410. Epub 2015 Jan 14. Int J Cancer. 2015. PMID: 25545165 Free PMC article.
Functional analyses further showed that ALDH(+) cells from ALDH-numerous AML were quiescent, refractory to ARA-C treatment and capable of leukemic engraftment in a xenogenic mouse transplantation model. Clinically, resistance to chemotherapy and poor long-term outcome were …
Functional analyses further showed that ALDH(+) cells from ALDH-numerous AML were quiescent, refractory to ARA-C treatment and capable of le …
23 results