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Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults.
Walters S, Contreras AG, Eissman JM, Mukherjee S, Lee ML, Choi SE, Scollard P, Trittschuh EH, Mez JB, Bush WS, Kunkle BW, Naj AC, Peterson A, Gifford KA, Cuccaro ML, Cruchaga C, Pericak-Vance MA, Farrer LA, Wang LS, Haines JL, Jefferson AL, Kukull WA, Keene CD, Saykin AJ, Thompson PM, Martin ER, Bennett DA, Barnes LL, Schneider JA, Crane PK, Hohman TJ, Dumitrescu L; Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Genetics Consortium, and Alzheimer’s Disease Sequencing Project. Walters S, et al. JAMA Neurol. 2023 Sep 1;80(9):929-939. doi: 10.1001/jamaneurol.2023.2169. JAMA Neurol. 2023. PMID: 37459083 Free PMC article.
The intersectional effect of race was modeled using an APOE sex race interaction term, assessing whether APOE sex interactions differed by race. Models were adjusted for age at baseline and corrected for multiple comparisons. ...
The intersectional effect of race was modeled using an APOE sex race interaction term, assessing whether APOE sex interactions differ …
Prion-like α-synuclein pathology in the brain of infants with Krabbe disease.
Hatton C, Ghanem SS, Koss DJ, Abdi IY, Gibbons E, Guerreiro R, Bras J; International DLB Genetics Consortium; Walker L, Gelpi E, Heywood W, Outeiro TF, Attems J, McFarland R, Forsyth R, El-Agnaf OM, Erskine D. Hatton C, et al. Brain. 2022 May 24;145(4):1257-1263. doi: 10.1093/brain/awac002. Brain. 2022. PMID: 34999780 Free PMC article.
GALC variants are also associated with Lewy body diseases, an umbrella term for age-associated neurodegenerative diseases in which the protein alpha-synuclein aggregates into Lewy bodies. ...
GALC variants are also associated with Lewy body diseases, an umbrella term for age-associated neurodegenerative diseases in which th …
Subjective Cognitive Complaint in Parkinson's Disease Patients With Normal Cognition: Canary in the Coal Mine?
Purri R, Brennan L, Rick J, Xie SX, Deck BL, Chahine LM, Dahodwala N, Chen-Plotkin A, Duda JE, Morley JF, Akhtar RS, Trojanowski JQ, Siderowf A, Weintraub D. Purri R, et al. Among authors: trojanowski jq. Mov Disord. 2020 Sep;35(9):1618-1625. doi: 10.1002/mds.28115. Epub 2020 Jun 10. Mov Disord. 2020. PMID: 32520435 Free PMC article.
CONCLUSIONS: Patients with PD with normal cognition, but with SCC, report poorer cognition-specific functional abilities, and are more likely to be diagnosed with cognitive impairment and experience global functional ability decline long term. These findings suggest that S …
CONCLUSIONS: Patients with PD with normal cognition, but with SCC, report poorer cognition-specific functional abilities, and are more likel …
Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer's disease.
Arena JD, Smith DH, Lee EB, Gibbons GS, Irwin DJ, Robinson JL, Lee VM, Trojanowski JQ, Stewart W, Johnson VE. Arena JD, et al. Among authors: trojanowski jq. Brain. 2020 May 1;143(5):1572-1587. doi: 10.1093/brain/awaa071. Brain. 2020. PMID: 32390044 Free PMC article.
Cases satisfying preliminary consensus diagnostic criteria for CTE neuropathological change (CTE-NC) were identified (athletes, n = 10; long-term survivors of moderate or severe TBI, n = 4) from the Glasgow TBI Archive and Penn Neurodegenerative Disease Brain Bank. ...
Cases satisfying preliminary consensus diagnostic criteria for CTE neuropathological change (CTE-NC) were identified (athletes, n = 10; long …
Analytical and Clinical Performance of Amyloid-Beta Peptides Measurements in CSF of ADNIGO/2 Participants by an LC-MS/MS Reference Method.
Korecka M, Figurski MJ, Landau SM, Brylska M, Alexander J, Blennow K, Zetterberg H, Jagust WJ, Trojanowski JQ, Shaw LM; Alzheimer’s Disease Neuroimaging Initiative. Korecka M, et al. Among authors: trojanowski jq. Clin Chem. 2020 Apr 1;66(4):587-597. doi: 10.1093/clinchem/hvaa012. Clin Chem. 2020. PMID: 32087019 Free PMC article.
Comparison of Abeta42 with Abeta42/Abeta40 showed that the ratio improved concordance with concurrent [18F]-florbetapir PET as a measure of fibrillar Abeta (n = 766) from 81 to 88%. CONCLUSIONS: Long-term performance assessment substantiates our modified LC-MS/MS reference …
Comparison of Abeta42 with Abeta42/Abeta40 showed that the ratio improved concordance with concurrent [18F]-florbetapir PET as a measure of …
Chronic traumatic encephalopathy - confusion and controversies.
Smith DH, Johnson VE, Trojanowski JQ, Stewart W. Smith DH, et al. Among authors: trojanowski jq. Nat Rev Neurol. 2019 Mar;15(3):179-183. doi: 10.1038/s41582-018-0114-8. Nat Rev Neurol. 2019. PMID: 30664683 Free PMC article. Review.
The term chronic traumatic encephalopathy (CTE) has recently entered public consciousness via media reports and even a Hollywood movie. ...
The term chronic traumatic encephalopathy (CTE) has recently entered public consciousness via media reports and even a Hollywood movi …
Statins and Cognition in Parkinson's Disease.
Deck BL, Rick J, Xie SX, Chen-Plotkin A, Duda JE, Morley JF, Chahine LM, Dahodwala N, Trojanowski JQ, Weintraub D. Deck BL, et al. Among authors: trojanowski jq. J Parkinsons Dis. 2017;7(4):661-667. doi: 10.3233/JPD-171113. J Parkinsons Dis. 2017. PMID: 28922167 Free PMC article.
In Cross-sectional analysis, SU performed better on global cognition, Trails B, semantic fluency, and phonemic fluency tasks. Rate of long-term global cognitive (Dementia Rating Scale-2 and MoCA) decline was significantly less in SU....
In Cross-sectional analysis, SU performed better on global cognition, Trails B, semantic fluency, and phonemic fluency tasks. Rate of long- …
Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases.
Kovacs GG, Robinson JL, Xie SX, Lee EB, Grossman M, Wolk DA, Irwin DJ, Weintraub D, Kim CF, Schuck T, Yousef A, Wagner ST, Suh E, Van Deerlin VM, Lee VM, Trojanowski JQ. Kovacs GG, et al. Among authors: trojanowski jq. J Neuropathol Exp Neurol. 2017 Apr 1;76(4):270-288. doi: 10.1093/jnen/nlx007. J Neuropathol Exp Neurol. 2017. PMID: 28340083 Free PMC article.
The term "aging-related tau astrogliopathy" (ARTAG) describes pathological accumulation of abnormally phosphorylated tau protein in astrocytes. ...
The term "aging-related tau astrogliopathy" (ARTAG) describes pathological accumulation of abnormally phosphorylated tau protein in a …
Milder Alzheimer's disease pathology in heart failure and atrial fibrillation.
Sposato LA, Ruíz Vargas E, Riccio PM, Toledo JB, Trojanowski JQ, Kukull WA, Cipriano LE, Nucera A, Whitehead SN, Hachinski V. Sposato LA, et al. Among authors: trojanowski jq. Alzheimers Dement. 2017 Jul;13(7):770-777. doi: 10.1016/j.jalz.2016.12.002. Epub 2017 Feb 5. Alzheimers Dement. 2017. PMID: 28174071 Free PMC article.

In the regression analyses, age (odds ratio [OR] 0.94, 95% confidence interval [CI] 0.93-0.95 per 1-year increase in age, P < .001) and the interaction term HF AF (OR 0.61, 95% CI 0.40-0.91, P = .014) were inversely related to severe AD pathology, whereas APOE epsilon4

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In the regression analyses, age (odds ratio [OR] 0.94, 95% confidence interval [CI] 0.93-0.95 per 1-year increase in age, P < .001) and t

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50 results