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The obligate need for accuracy in reporting preclinical studies relevant to clinical trials: autologous germline mitochondrial supplementation for assisted human reproduction as a case study.
Tilly JL, Woods DC. Tilly JL, et al. Ther Adv Reprod Health. 2020 Apr 23;14:2633494120917350. doi: 10.1177/2633494120917350. eCollection 2020 Jan-Dec. Ther Adv Reprod Health. 2020. PMID: 32518919 Free PMC article. Review.
Initial trials of autologous germline mitochondrial energy transfer during - in vitro fertilization at three different sites with a total of 104 patients indicated a benefit of the procedure for improving pregnancy success rates, with the birth of children conceived throug …
Initial trials of autologous germline mitochondrial energy transfer during - in vitro fertilization at three different sites with a total of …
Ovarian regeneration: The potential for stem cell contribution in the postnatal ovary to sustained endocrine function.
Truman AM, Tilly JL, Woods DC. Truman AM, et al. Among authors: tilly jl. Mol Cell Endocrinol. 2017 Apr 15;445:74-84. doi: 10.1016/j.mce.2016.10.012. Epub 2016 Oct 12. Mol Cell Endocrinol. 2017. PMID: 27743990 Free PMC article. Review.
Herein, we review the relative contributions of ovarian stem cells to ovarian function during the reproductive lifespan, and postulate steps toward the development of ovarian stem cell-based approaches to advance fertility treatments, and also importantly to provide a physiologic …
Herein, we review the relative contributions of ovarian stem cells to ovarian function during the reproductive lifespan, and postulate steps …
Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids.
Nehra D, Le HD, Fallon EM, Carlson SJ, Woods D, White YA, Pan AH, Guo L, Rodig SJ, Tilly JL, Rueda BR, Puder M. Nehra D, et al. Among authors: tilly jl. Aging Cell. 2012 Dec;11(6):1046-54. doi: 10.1111/acel.12006. Epub 2012 Oct 19. Aging Cell. 2012. PMID: 22978268 Free PMC article.
Women approaching advanced maternal age have extremely poor outcomes with both natural and assisted fertility. Moreover, the incidence of chromosomal abnormalities and birth defects increases with age. As of yet, there is no effective and practical strategy for delaying ov …
Women approaching advanced maternal age have extremely poor outcomes with both natural and assisted fertility. Moreover, the incidence of ch …
In vivo delivery of FTY720 prevents radiation-induced ovarian failure and infertility in adult female nonhuman primates.
Zelinski MB, Murphy MK, Lawson MS, Jurisicova A, Pau KY, Toscano NP, Jacob DS, Fanton JK, Casper RF, Dertinger SD, Tilly JL. Zelinski MB, et al. Among authors: tilly jl. Fertil Steril. 2011 Mar 15;95(4):1440-5.e1-7. doi: 10.1016/j.fertnstert.2011.01.012. Fertil Steril. 2011. PMID: 21316047 Free PMC article.
OBJECTIVE: To determine whether sphingosine-1-phosphate (S1P), or the S1P mimetic FTY720 shields ovaries of adult female rhesus monkeys from damage caused by 15 Gy of targeted radiotherapy, allowing for the retention of long-term fertility, and to evaluate whether S1P prot …
OBJECTIVE: To determine whether sphingosine-1-phosphate (S1P), or the S1P mimetic FTY720 shields ovaries of adult female rhesus monkeys from …
Bone marrow transplantation generates immature oocytes and rescues long-term fertility in a preclinical mouse model of chemotherapy-induced premature ovarian failure.
Lee HJ, Selesniemi K, Niikura Y, Niikura T, Klein R, Dombkowski DM, Tilly JL. Lee HJ, et al. Among authors: tilly jl. J Clin Oncol. 2007 Aug 1;25(22):3198-204. doi: 10.1200/JCO.2006.10.3028. J Clin Oncol. 2007. PMID: 17664466
Immune cells were sorted from blood and analyzed for germline markers. RESULTS: BMT rescued long-term fertility in CTx-treated females, but all offspring were derived from the recipient germline. ...
Immune cells were sorted from blood and analyzed for germline markers. RESULTS: BMT rescued long-term fertility in CTx-treated female …
Sphingolipids, apoptosis, cancer treatments and the ovary: investigating a crime against female fertility.
Tilly JL, Kolesnick RN. Tilly JL, et al. Biochim Biophys Acta. 2002 Dec 30;1585(2-3):135-8. doi: 10.1016/s1388-1981(02)00333-5. Biochim Biophys Acta. 2002. PMID: 12531546 Review.
Although the need for tumor eradication in these patients is clear, the long-term consequences of chemotherapy and radiation on non-target tissues, such as the ovaries where large numbers of germ cells (oocytes) are also killed off, are substantial. ...
Although the need for tumor eradication in these patients is clear, the long-term consequences of chemotherapy and radiation on non-t …
Expression of BCL-2, BAX and BAK in the trophoblast layer of the term human placenta: a unique model of apoptosis within a syncytium.
Ratts VS, Tao XJ, Webster CB, Swanson PE, Smith SD, Brownbill P, Krajewski S, Reed JC, Tilly JL, Nelson DM. Ratts VS, et al. Among authors: tilly jl. Placenta. 2000 May;21(4):361-6. doi: 10.1053/plac.1999.0486. Placenta. 2000. PMID: 10833371
TUNEL (terminal deoxynucleotidyltransferase-mediated dUTP end-labelling) staining to detect DNA fragmentation typical of apoptosis was performed in term human placentae revealing labelled nuclei associated with fibrin-type fibrinoid, as well as labelled nuclei in discrete …
TUNEL (terminal deoxynucleotidyltransferase-mediated dUTP end-labelling) staining to detect DNA fragmentation typical of apoptosis was perfo …
Hormonal modulation of apoptosis in the rat adrenal gland in vitro is dependent on structural integrity.
Carsia RV, Tilly KI, Tilly JL. Carsia RV, et al. Among authors: tilly jl. Endocrine. 1997 Dec;7(3):377-81. doi: 10.1007/BF02801333. Endocrine. 1997. PMID: 9657076
The intact rat adrenal gland in short-term (3-h) organ culture may be amenable for the identification of factors involved in regulating adrenal cell apoptosis under defined conditions. ...
The intact rat adrenal gland in short-term (3-h) organ culture may be amenable for the identification of factors involved in regulati …
Induction of PreB cell apoptosis by 7,12-dimethylbenz[a]anthracene in long-term primary murine bone marrow cultures.
Yamaguchi K, Matulka RA, Shneider AM, Toselli P, Trombino AF, Yang S, Hafer LJ, Mann KK, Tao XJ, Tilly JL, Near RI, Sherr DH. Yamaguchi K, et al. Among authors: tilly jl. Toxicol Appl Pharmacol. 1997 Dec;147(2):190-203. doi: 10.1006/taap.1997.8263. Toxicol Appl Pharmacol. 1997. PMID: 9439715 Free article.
Relatively few studies have assessed the effects of these common environmental chemicals on immature lymphocytes. In the present study, long-term primary bone marrow cultures were employed to investigate the effects of a prototypic PAH and aryl hydrocarbon receptor (AhR) a …
Relatively few studies have assessed the effects of these common environmental chemicals on immature lymphocytes. In the present study, long …
Biphasic developmental expression of adrenocorticotropin receptor messenger ribonucleic acid levels in the baboon fetal adrenal gland.
Albrecht ED, Aberdeen GW, Babischkin JS, Tilly JL, Pepe GJ. Albrecht ED, et al. Among authors: tilly jl. Endocrinology. 1996 Apr;137(4):1292-8. doi: 10.1210/endo.137.4.8625902. Endocrinology. 1996. PMID: 8625902
A baboon ACTH receptor complementary DNA was cloned and hybridized with polyadenylated RNA isolated from baboon (Papio anubis) fetal adrenals obtained in early (days 58-64; RNA from seven baboon fetuses pooled to yield three samples), mid-(days 99-103; RNA from five baboons poole …
A baboon ACTH receptor complementary DNA was cloned and hybridized with polyadenylated RNA isolated from baboon (Papio anubis) fetal adrenal …
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