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Circulating MicroRNA Profiling Identifies Distinct MicroRNA Signatures in Acute Ischemic Stroke and Transient Ischemic Attack Patients.
Toor SM, Aldous EK, Parray A, Akhtar N, Al-Sarraj Y, Abdelalim EM, Arredouani A, El-Agnaf O, Thornalley PJ, Pananchikkal SV, Pir GJ, Ayadathil R, Shuaib A, Alajez NM, Albagha OME. Toor SM, et al. Among authors: thornalley pj. Int J Mol Sci. 2022 Dec 21;24(1):108. doi: 10.3390/ijms24010108. Int J Mol Sci. 2022. PMID: 36613546 Free PMC article. Clinical Trial.
Understanding the differences in molecular pathways in AIS and TIA has merit for deciphering the underlying cause for neuronal deficits with long-term effects and high risks of morbidity and mortality. In this study, we performed comprehensive investigations into the circu …
Understanding the differences in molecular pathways in AIS and TIA has merit for deciphering the underlying cause for neuronal deficits with …
Protein glycation - biomarkers of metabolic dysfunction and early-stage decline in health in the era of precision medicine.
Rabbani N, Thornalley PJ. Rabbani N, et al. Among authors: thornalley pj. Redox Biol. 2021 Jun;42:101920. doi: 10.1016/j.redox.2021.101920. Epub 2021 Feb 26. Redox Biol. 2021. PMID: 33707127 Free PMC article.
It is a biomarker for diagnosis of diabetes and prediabetes and of medium-term glycemic control in patients with established diabetes. A1C is an early-stage glycation adduct of hemoglobin with glucose; a fructosamine derivative. ...
It is a biomarker for diagnosis of diabetes and prediabetes and of medium-term glycemic control in patients with established diabetes …
Quantitative measurement of specific biomarkers for protein oxidation, nitration and glycation in Arabidopsis leaves.
Bechtold U, Rabbani N, Mullineaux PM, Thornalley PJ. Bechtold U, et al. Among authors: thornalley pj. Plant J. 2009 Aug;59(4):661-71. doi: 10.1111/j.1365-313X.2009.03898.x. Epub 2009 Apr 25. Plant J. 2009. PMID: 19392687 Free article.
A comparison between wild-type plants and a mutant lacking peptide methionine sulfoxide reductase (pmsr2-1) showed increased protein oxidation, nitration and glycation of specific amino acid residues during darkness in pmsr2-1. Short-term excess light exposure, which promo …
A comparison between wild-type plants and a mutant lacking peptide methionine sulfoxide reductase (pmsr2-1) showed increased protein oxidati …
Glycation in diabetic neuropathy: characteristics, consequences, causes, and therapeutic options.
Thornalley PJ. Thornalley PJ. Int Rev Neurobiol. 2002;50:37-57. doi: 10.1016/s0074-7742(02)50072-6. Int Rev Neurobiol. 2002. PMID: 12198817 Review.
Early glycation adducts (fructosamines) and advanced glycation adducts (AGEs) are formed. "Glycoxidation" is a term used for glycation processes involving oxidation. Sural, peroneal, and saphenous nerves of human diabetic subjects contained AGEs in the perineurium, endothe …
Early glycation adducts (fructosamines) and advanced glycation adducts (AGEs) are formed. "Glycoxidation" is a term used for glycatio …
Suppression of the accumulation of triosephosphates and increased formation of methylglyoxal in human red blood cells during hyperglycaemia by thiamine in vitro.
Thornalley PJ, Jahan I, Ng R. Thornalley PJ, et al. J Biochem. 2001 Apr;129(4):543-9. doi: 10.1093/oxfordjournals.jbchem.a002889. J Biochem. 2001. PMID: 11275553 Free article.
To assess the effect of thiamine supplementation on the accumulation of triosephosphates and methylglyoxal formation in cellular hyperglycaemia, we incubated human red blood cell suspensions (50% v/v) in short-term culture with 5 mM glucose and 50 mM glucose in Krebs-Ringe …
To assess the effect of thiamine supplementation on the accumulation of triosephosphates and methylglyoxal formation in cellular hyperglycae …