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Exercised-based cardiac rehabilitation associates with lower all-cause mortality in patients with primary pulmonary hypertension.
Kleinnibbelink G, Buckley BJR, Harrison SL, Williams N, Fazio-Eynullayeva E, Underhill P, van Dijk APJ, Lip GYH, Thijssen DHJ. Kleinnibbelink G, et al. Among authors: thijssen dhj. Front Sports Act Living. 2023 Dec 11;5:1247615. doi: 10.3389/fspor.2023.1247615. eCollection 2023. Front Sports Act Living. 2023. PMID: 38152382 Free PMC article.
BACKGROUND: Despite pharmacological therapies to improve outcomes of pulmonary hypertension (PH), poor long-term survival remains. Exercised-based cardiac rehabilitation (ExCR) may be an alternative strategy to improve prognosis. ...
BACKGROUND: Despite pharmacological therapies to improve outcomes of pulmonary hypertension (PH), poor long-term survival remains. Ex …
The Hypoxia Response Pathway: A Potential Intervention Target in Parkinson's Disease?
Janssen Daalen JM, Koopman WJH, Saris CGJ, Meinders MJ, Thijssen DHJ, Bloem BR. Janssen Daalen JM, et al. Among authors: thijssen dhj. Mov Disord. 2024 Feb;39(2):273-293. doi: 10.1002/mds.29688. Epub 2023 Dec 23. Mov Disord. 2024. PMID: 38140810 Review.
We highlight the mechanistic differences between the rescuing effects of chronic hypoxia in neurodegeneration and short-term moderate hypoxia to improve neuronal resilience, termed "hypoxic conditioning". ...
We highlight the mechanistic differences between the rescuing effects of chronic hypoxia in neurodegeneration and short-term moderate …
Vascular Function, Systemic Inflammation, and Coagulation Activation 18 Months after COVID-19 Infection: An Observational Cohort Study.
Willems LH, Jacobs LMC, Groh LA, Ten Cate H, Spronk HMH, Wilson-Storey B, Hannink G, van Kuijk SMJ, Ghossein-Doha C, Nagy M, Thijssen DHJ, van Petersen AS, Warlé MC. Willems LH, et al. Among authors: thijssen dhj. J Clin Med. 2023 Feb 10;12(4):1413. doi: 10.3390/jcm12041413. J Clin Med. 2023. PMID: 36835948 Free PMC article.
Previous research has shown no indication of macrovascular dysfunction as reflected by carotid artery reactivity, but has shown sustained microvascular dysfunction, systemic inflammation, and coagulation activation at 3 months after acute COVID-19. The long-term effects of …
Previous research has shown no indication of macrovascular dysfunction as reflected by carotid artery reactivity, but has shown sustained mi …
Imatinib attenuates reperfusion injury in a rat model of acute myocardial infarction.
Konijnenberg LSF, Luiken TTJ, Veltien A, Uthman L, Kuster CTA, Rodwell L, de Waard GA, Kea-Te Lindert M, Akiva A, Thijssen DHJ, Nijveldt R, van Royen N. Konijnenberg LSF, et al. Among authors: thijssen dhj. Basic Res Cardiol. 2023 Jan 13;118(1):2. doi: 10.1007/s00395-022-00974-z. Basic Res Cardiol. 2023. PMID: 36639597 Free PMC article.
Following an acute myocardial infarction, reperfusion of an occluded coronary artery is often accompanied by microvascular injury, leading to worse long-term prognosis. Experimental studies have revealed the potential of tyrosine-kinase inhibitor imatinib to reduce vascula …
Following an acute myocardial infarction, reperfusion of an occluded coronary artery is often accompanied by microvascular injury, leading t …
Long-term cardiovascular health status and physical functioning of nonhospitalized patients with COVID-19 compared with non-COVID-19 controls.
van der Sluijs KM, Bakker EA, Schuijt TJ, Joseph J, Kavousi M, Geersing GJ, Rutten FH, Hartman YAW, Thijssen DHJ, Eijsvogels TMH. van der Sluijs KM, et al. Among authors: thijssen dhj. Am J Physiol Heart Circ Physiol. 2023 Jan 1;324(1):H47-H56. doi: 10.1152/ajpheart.00335.2022. Epub 2022 Dec 2. Am J Physiol Heart Circ Physiol. 2023. PMID: 36459448 Free PMC article.
Coronavirus disease 2019 (COVID-19) is reported to have long-term effects on cardiovascular health and physical functioning, even in the nonhospitalized population. ...Follow-up studies should investigate the origins of residual symptoms and their long-term conseque …
Coronavirus disease 2019 (COVID-19) is reported to have long-term effects on cardiovascular health and physical functioning, even in …
Twelve-Week Daily Gluteal and Hamstring Electrical Stimulation Improves Vascular Structure and Function, Limb Volume, and Sitting Pressure in Spinal Cord Injury: A Pilot Feasibility Study.
Barton T, Low DA, Thijssen DHJ, Romviel S, Sloots M, Smit CAJ, Janssen TWJ. Barton T, et al. Among authors: thijssen dhj. Am J Phys Med Rehabil. 2022 Oct 1;101(10):913-919. doi: 10.1097/PHM.0000000000001929. Epub 2021 Nov 17. Am J Phys Med Rehabil. 2022. PMID: 36104843
OBJECTIVE: We examined the long-term effects of low-intensity electrical stimulation on (micro)vasculature and sitting pressure of a home-based, wearable electrical stimulation device in a pilot feasibility study. ...
OBJECTIVE: We examined the long-term effects of low-intensity electrical stimulation on (micro)vasculature and sitting pressure of a …
Multiple N-of-1 trials to investigate hypoxia therapy in Parkinson's disease: study rationale and protocol.
Janssen Daalen JM, Meinders MJ, Giardina F, Roes KCB, Stunnenberg BC, Mathur S, Ainslie PN, Thijssen DHJ, Bloem BR. Janssen Daalen JM, et al. Among authors: thijssen dhj. BMC Neurol. 2022 Jul 14;22(1):262. doi: 10.1186/s12883-022-02770-7. BMC Neurol. 2022. PMID: 35836147 Free PMC article.
Preclinical and clinical evidence suggest that hypoxia-based therapy might have short- and long-term benefits in PD. We present the contours of the first study to assess the safety, feasibility and physiological and symptomatic impact of hypoxia-based therapy in individual …
Preclinical and clinical evidence suggest that hypoxia-based therapy might have short- and long-term benefits in PD. We present the c …
Atrial Fibrillation Specific Exercise Rehabilitation: Are We There Yet?
Buckley BJR, Risom SS, Boidin M, Lip GYH, Thijssen DHJ. Buckley BJR, et al. Among authors: thijssen dhj. J Pers Med. 2022 Apr 10;12(4):610. doi: 10.3390/jpm12040610. J Pers Med. 2022. PMID: 35455726 Free PMC article. Review.
Collating data from 21 studies, we propose that 360-720 metabolic equivalent (MET)-minutes/week, corresponding to ~60-120 min of exercise per week at moderate-to-vigorous intensity, could be an evidence-based recommendation for patients with AF to improve AF-specific outcomes, qu …
Collating data from 21 studies, we propose that 360-720 metabolic equivalent (MET)-minutes/week, corresponding to ~60-120 min of exercise pe …
Short-term exercise-induced protection of cardiovascular function and health: why and how fast does the heart benefit from exercise?
Thijssen DHJ, Uthman L, Somani Y, van Royen N. Thijssen DHJ, et al. J Physiol. 2022 Mar;600(6):1339-1355. doi: 10.1113/JP282000. Epub 2022 Mar 3. J Physiol. 2022. PMID: 35239189 Free PMC article. Review.
Studies, performed in both animals and humans, demonstrate that single or short-term exercise-induced protection (SEP) attenuates the magnitude of cardiac and/or vascular damage in response to prolonged ischaemia and reperfusion injury. ...Finally, we discuss potential fut …
Studies, performed in both animals and humans, demonstrate that single or short-term exercise-induced protection (SEP) attenuates the …
High Levels of Sedentary Time in Patients with COVID-19 after Hospitalisation.
van Bakel BMA, van den Heuvel FMA, Vos JL, Rotbi H, Bakker EA, Nijveldt R, Thijssen DHJ, Eijsvogels TMH. van Bakel BMA, et al. Among authors: thijssen dhj. J Clin Med. 2022 Feb 19;11(4):1110. doi: 10.3390/jcm11041110. J Clin Med. 2022. PMID: 35207383 Free PMC article.
Many patients with COVID-19 experience severe and even fatal disease. Survivors may have long-term health consequences, but data on physical activity and sedentary behaviour are scarce. ...
Many patients with COVID-19 experience severe and even fatal disease. Survivors may have long-term health consequences, but data on p …
39 results