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An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence.
Riviere-Cazaux C, Carlstrom LP, Neth BJ, Olson IE, Rajani K, Rahman M, Ikram S, Mansour MA, Mukherjee B, Warrington AE, Short SC, von Zglinicki T, Brown DA, Burma S, Tchkonia T, Schafer MJ, Baker DJ, Kizilbash SH, Kirkland JL, Burns TC. Riviere-Cazaux C, et al. Among authors: tchkonia t. NPJ Precis Oncol. 2023 Nov 29;7(1):126. doi: 10.1038/s41698-023-00476-8. NPJ Precis Oncol. 2023. PMID: 38030881 Free PMC article. Review.
High-grade gliomas are primary brain tumors that are incredibly refractory long-term to surgery and chemoradiation, with no proven durable salvage therapies for patients that have failed conventional treatments. ...We also discuss how senescent cell clearance can decrease …
High-grade gliomas are primary brain tumors that are incredibly refractory long-term to surgery and chemoradiation, with no proven du …
Role of senescence in the chronic health consequences of COVID-19.
Wissler Gerdes EO, Vanichkachorn G, Verdoorn BP, Hanson GJ, Joshi AY, Murad MH, Rizza SA, Hurt RT, Tchkonia T, Kirkland JL. Wissler Gerdes EO, et al. Among authors: tchkonia t. Transl Res. 2022 Mar;241:96-108. doi: 10.1016/j.trsl.2021.10.003. Epub 2021 Oct 22. Transl Res. 2022. PMID: 34695606 Free PMC article. Review.
Innate immune system dysfunction that leads to decreased senescent cell removal and/or increased senescent cell formation could contribute to accumulation of senescent cells with both aging and viral infections. These processes may contribute to increased risk for long-term …
Innate immune system dysfunction that leads to decreased senescent cell removal and/or increased senescent cell formation could contribute t …
SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3.
Tripathi U, Nchioua R, Prata LGPL, Zhu Y, Gerdes EOW, Giorgadze N, Pirtskhalava T, Parker E, Xue A, Espindola-Netto JM, Stenger S, Robbins PD, Niedernhofer LJ, Dickinson SL, Allison DB, Kirchhoff F, Sparrer KMJ, Tchkonia T, Kirkland JL. Tripathi U, et al. Among authors: tchkonia t. Aging (Albany NY). 2021 Sep 16;13(18):21838-21854. doi: 10.18632/aging.203560. Epub 2021 Sep 16. Aging (Albany NY). 2021. PMID: 34531331 Free PMC article.
Our results suggest that induction of cellular senescence and SASP amplification through TLR-3 contribute to SARS-CoV-2 morbidity, indicating that clinical trials of senolytics and/or SASP/TLR-3 inhibitors for alleviating acute and long-term SARS-CoV-2 sequelae are warrant …
Our results suggest that induction of cellular senescence and SASP amplification through TLR-3 contribute to SARS-CoV-2 morbidity, indicatin …
Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era.
Verdoorn BP, Evans TK, Hanson GJ, Zhu Y, Langhi Prata LGP, Pignolo RJ, Atkinson EJ, Wissler-Gerdes EO, Kuchel GA, Mannick JB, Kritchevsky SB, Khosla S, Rizza SA, Walston JD, Musi N, Lipsitz LA, Kiel DP, Yung R, LeBrasseur NK, Singh RJ, McCarthy T, Puskarich MA, Niedernhofer LJ, Robbins PD, Sorenson M, Tchkonia T, Kirkland JL. Verdoorn BP, et al. Among authors: tchkonia t. J Am Geriatr Soc. 2021 Nov;69(11):3023-3033. doi: 10.1111/jgs.17416. Epub 2021 Aug 20. J Am Geriatr Soc. 2021. PMID: 34375437 Free PMC article.
We consider logistic challenges of conducting trials in long-term care settings in the SARS-CoV-2 era, including restricted access, consent procedures, methods for obtaining biospecimens and clinical data, staffing, investigational product administration issues, and potent …
We consider logistic challenges of conducting trials in long-term care settings in the SARS-CoV-2 era, including restricted access, c …
Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice.
Stojakovic A, Trushin S, Sheu A, Khalili L, Chang SY, Li X, Christensen T, Salisbury JL, Geroux RE, Gateno B, Flannery PJ, Dehankar M, Funk CC, Wilkins J, Stepanova A, O'Hagan T, Galkin A, Nesbitt J, Zhu X, Tripathi U, Macura S, Tchkonia T, Pirtskhalava T, Kirkland JL, Kudgus RA, Schoon RA, Reid JM, Yamazaki Y, Kanekiyo T, Zhang S, Nemutlu E, Dzeja P, Jaspersen A, Kwon YIC, Lee MK, Trushina E. Stojakovic A, et al. Among authors: tchkonia t. Commun Biol. 2021 Jan 8;4(1):61. doi: 10.1038/s42003-020-01584-y. Commun Biol. 2021. PMID: 33420340 Free PMC article.
Treatment of symptomatic APP/PS1 mice with complex I inhibitor improved energy homeostasis, synaptic activity, long-term potentiation, dendritic spine maturation, cognitive function and proteostasis, and reduced oxidative stress and inflammation in brain and periphery, ult …
Treatment of symptomatic APP/PS1 mice with complex I inhibitor improved energy homeostasis, synaptic activity, long-term potentiation …
Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice.
Saccon TD, Nagpal R, Yadav H, Cavalcante MB, Nunes ADC, Schneider A, Gesing A, Hughes B, Yousefzadeh M, Tchkonia T, Kirkland JL, Niedernhofer LJ, Robbins PD, Masternak MM. Saccon TD, et al. Among authors: tchkonia t. J Gerontol A Biol Sci Med Sci. 2021 Oct 13;76(11):1895-1905. doi: 10.1093/gerona/glab002. J Gerontol A Biol Sci Med Sci. 2021. PMID: 33406219 Free PMC article.
The senolytic drug combination, Dasatinib plus Quercetin (D+Q), is known to reduce senescent cell abundance in aged mice. However, the effects of long-term D+Q treatment on intestinal senescent cell and inflammatory burden and microbiome composition in aged mice remain unk …
The senolytic drug combination, Dasatinib plus Quercetin (D+Q), is known to reduce senescent cell abundance in aged mice. However, the effec …
Biology of premature ageing in survivors of cancer.
Cupit-Link MC, Kirkland JL, Ness KK, Armstrong GT, Tchkonia T, LeBrasseur NK, Armenian SH, Ruddy KJ, Hashmi SK. Cupit-Link MC, et al. Among authors: tchkonia t. ESMO Open. 2017 Dec 18;2(5):e000250. doi: 10.1136/esmoopen-2017-000250. eCollection 2017. ESMO Open. 2017. PMID: 29326844 Free PMC article. Review.
We review the effects of cancer therapies on recognised hallmarks of ageing. Long-term comorbidities seen in cancer survivors mimic the phenotypes of ageing and likely result from the interaction between therapeutic exposures and the underlying biology of ageing. Long-t …
We review the effects of cancer therapies on recognised hallmarks of ageing. Long-term comorbidities seen in cancer survivors mimic t …
Muscle-specific differences in expression and phosphorylation of the Janus kinase 2/Signal Transducer and Activator of Transcription 3 following long-term mechanical ventilation and immobilization in rats.
Salah H, Fury W, Gromada J, Bai Y, Tchkonia T, Kirkland JL, Larsson L. Salah H, et al. Among authors: tchkonia t. Acta Physiol (Oxf). 2018 Mar;222(3). doi: 10.1111/apha.12980. Epub 2017 Oct 30. Acta Physiol (Oxf). 2018. PMID: 29032602
This study aimed at investigating the temporal expression and phosphorylation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway in muscle wasting associated with the ICU condition to characterize the JAK/STAT proteins and the related changes …
This study aimed at investigating the temporal expression and phosphorylation of the Janus kinase/signal transducer and activator of transcr …
The Clinical Potential of Senolytic Drugs.
Kirkland JL, Tchkonia T, Zhu Y, Niedernhofer LJ, Robbins PD. Kirkland JL, et al. Among authors: tchkonia t. J Am Geriatr Soc. 2017 Oct;65(10):2297-2301. doi: 10.1111/jgs.14969. Epub 2017 Sep 4. J Am Geriatr Soc. 2017. PMID: 28869295 Free PMC article.
To do so, new clinical trial paradigms for testing senolytics and other agents that target fundamental aging mechanisms are being developed, because use of long-term endpoints such as lifespan or healthspan is not feasible. These strategies include testing effects on multi …
To do so, new clinical trial paradigms for testing senolytics and other agents that target fundamental aging mechanisms are being developed, …
Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.
Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK. Schafer MJ, et al. Among authors: tchkonia t. Diabetes. 2016 Jun;65(6):1606-15. doi: 10.2337/db15-0291. Epub 2016 Mar 16. Diabetes. 2016. PMID: 26983960 Free PMC article.
We show that exercise prevents the accumulation of senescent cells and the expression of the SASP while nullifying the damaging effects of the FFD on parameters of health. We also demonstrate that exercise initiated after long-term FFD feeding reduces senescent phenotype m …
We show that exercise prevents the accumulation of senescent cells and the expression of the SASP while nullifying the damaging effects of t …
11 results