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Ketamine evoked disruption of entorhinal and hippocampal spatial maps.
Masuda FK, Aery Jones EA, Sun Y, Giocomo LM. Masuda FK, et al. Nat Commun. 2023 Oct 7;14(1):6285. doi: 10.1038/s41467-023-41750-4. Nat Commun. 2023. PMID: 37805575 Free PMC article.
Ketamine acutely increased firing rates, degraded cell-pair temporal firing-rate relationships, and altered oscillations, leading to longer-term remapping of spatial representations. In the reciprocally connected hippocampus, the activity of neurons that encode the positio …
Ketamine acutely increased firing rates, degraded cell-pair temporal firing-rate relationships, and altered oscillations, leading to longer- …
Ketamine evoked disruption of entorhinal and hippocampal spatial maps.
Masuda FK, Sun Y, Aery Jones EA, Giocomo LM. Masuda FK, et al. bioRxiv [Preprint]. 2023 Feb 6:2023.02.05.527227. doi: 10.1101/2023.02.05.527227. bioRxiv. 2023. PMID: 36798242 Free PMC article. Updated. Preprint.
Here, we used electrophysiology and calcium imaging to examine ketamine's impacts on the medial entorhinal cortex and hippocampus, which contain neurons that encode an animal's spatial position, as mice navigated virtual reality and real world environments. Ketamine induced an ac …
Here, we used electrophysiology and calcium imaging to examine ketamine's impacts on the medial entorhinal cortex and hippocampus, which con …
Temporal signaling, population control, and information processing through chromatin-mediated gene regulation.
Mukund A, Bintu L. Mukund A, et al. J Theor Biol. 2022 Feb 21;535:110977. doi: 10.1016/j.jtbi.2021.110977. Epub 2021 Dec 14. J Theor Biol. 2022. PMID: 34919934 Free PMC article.
We integrate this mode of regulation with classical gene regulatory motifs, such as autoregulatory and incoherent feedforward loops, to determine the types of responses achievable with duration-dependent signaling. We demonstrate that repressive regulators without long-term …
We integrate this mode of regulation with classical gene regulatory motifs, such as autoregulatory and incoherent feedforward loops, to dete …
Gene editing to enhance the efficacy of cancer cell therapies.
Murty T, Mackall CL. Murty T, et al. Mol Ther. 2021 Nov 3;29(11):3153-3162. doi: 10.1016/j.ymthe.2021.10.001. Epub 2021 Oct 18. Mol Ther. 2021. PMID: 34673274 Free PMC article. Review.
This review discusses gene editing approaches that have been the best studied in the context of human T cells and adoptive T cell therapies, summarizing their current status and near-term potential for translation....
This review discusses gene editing approaches that have been the best studied in the context of human T cells and adoptive T cell therapies, …
Computational drug repositioning of atorvastatin for ulcerative colitis.
Bai L, Scott MKD, Steinberg E, Kalesinskas L, Habtezion A, Shah NH, Khatri P. Bai L, et al. J Am Med Inform Assoc. 2021 Oct 12;28(11):2325-2335. doi: 10.1093/jamia/ocab165. J Am Med Inform Assoc. 2021. PMID: 34529084 Free PMC article.
OBJECTIVE: Ulcerative colitis (UC) is a chronic inflammatory disorder with limited effective therapeutic options for long-term treatment and disease maintenance. We hypothesized that a multi-cohort analysis of independent cohorts representing real-world heterogeneity of UC …
OBJECTIVE: Ulcerative colitis (UC) is a chronic inflammatory disorder with limited effective therapeutic options for long-term treatm …
Revisiting Stem Cell-Based Clinical Trials for Ischemic Stroke.
He JQ, Sussman ES, Steinberg GK. He JQ, et al. Front Aging Neurosci. 2020 Dec 14;12:575990. doi: 10.3389/fnagi.2020.575990. eCollection 2020. Front Aging Neurosci. 2020. PMID: 33381020 Free PMC article.
Stroke is the leading cause of serious long-term disability, significantly reducing mobility in almost half of the affected patients aged 65 years and older. ...
Stroke is the leading cause of serious long-term disability, significantly reducing mobility in almost half of the affected patients …
Progenitor identification and SARS-CoV-2 infection in human distal lung organoids.
Salahudeen AA, Choi SS, Rustagi A, Zhu J, van Unen V, de la O SM, Flynn RA, Margalef-Català M, Santos AJM, Ju J, Batish A, Usui T, Zheng GXY, Edwards CE, Wagar LE, Luca V, Anchang B, Nagendran M, Nguyen K, Hart DJ, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Harbury PB, Glenn JS, Garcia KC, Davis MM, Baric RS, Sabatti C, Amieva MR, Blish CA, Desai TJ, Kuo CJ. Salahudeen AA, et al. Nature. 2020 Dec;588(7839):670-675. doi: 10.1038/s41586-020-3014-1. Epub 2020 Nov 25. Nature. 2020. PMID: 33238290 Free PMC article.
Three-dimensional in vitro human distal lung culture systems would strongly facilitate the investigation of pathologies such as interstitial lung disease, cancer and coronavirus disease 2019 (COVID-19) pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV- …
Three-dimensional in vitro human distal lung culture systems would strongly facilitate the investigation of pathologies such as interstitial …
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains.
Pluvinage JV, Haney MS, Smith BAH, Sun J, Iram T, Bonanno L, Li L, Lee DP, Morgens DW, Yang AC, Shuken SR, Gate D, Scott M, Khatri P, Luo J, Bertozzi CR, Bassik MC, Wyss-Coray T. Pluvinage JV, et al. Nature. 2019 Apr;568(7751):187-192. doi: 10.1038/s41586-019-1088-4. Epub 2019 Apr 3. Nature. 2019. PMID: 30944478 Free PMC article.
CD22 mediates the anti-phagocytic effect of alpha2,6-linked sialic acid, and inhibition of CD22 promotes the clearance of myelin debris, amyloid-beta oligomers and alpha-synuclein fibrils in vivo. Long-term central nervous system delivery of an antibody that blocks CD22 fu …
CD22 mediates the anti-phagocytic effect of alpha2,6-linked sialic acid, and inhibition of CD22 promotes the clearance of myelin debris, amy …
Generation and assembly of human brain region-specific three-dimensional cultures.
Sloan SA, Andersen J, Pașca AM, Birey F, Pașca SP. Sloan SA, et al. Nat Protoc. 2018 Sep;13(9):2062-2085. doi: 10.1038/s41596-018-0032-7. Nat Protoc. 2018. PMID: 30202107 Free PMC article.
Astrocytes are also present in the human forebrain-specific spheroids, and these undergo maturation when the forebrain spheroids are cultured long term. The initial generation of neural spheroids from hPSCs occurs in <1 week, with regional patterning occurring over the …
Astrocytes are also present in the human forebrain-specific spheroids, and these undergo maturation when the forebrain spheroids are culture …
Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche.
Chen JY, Miyanishi M, Wang SK, Yamazaki S, Sinha R, Kao KS, Seita J, Sahoo D, Nakauchi H, Weissman IL. Chen JY, et al. Nature. 2016 Feb 11;530(7589):223-7. doi: 10.1038/nature16943. Nature. 2016. PMID: 26863982 Free PMC article.
Here we demonstrate by unbiased multi-step screening, identification of a single gene, homeobox B5 (Hoxb5, also known as Hox-2.1), with expression in the bone marrow that is limited to long-term (LT)-HSCs in mice. Using a mouse single-colour tri-mCherry reporter driven by …
Here we demonstrate by unbiased multi-step screening, identification of a single gene, homeobox B5 (Hoxb5, also known as Hox-2.1), with expr …
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