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Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity.
Shapiro MB, Cheever T, Malherbe DC, Pandey S, Reed J, Yang ES, Wang K, Pegu A, Chen X, Siess D, Burke D, Henderson H, Lewinsohn R, Fischer M, Stanton JJ, Axthelm MK, Kahl C, Park B, Lewis AD, Sacha JB, Mascola JR, Hessell AJ, Haigwood NL. Shapiro MB, et al. Nat Commun. 2020 Jan 7;11(1):70. doi: 10.1038/s41467-019-13972-y. Nat Commun. 2020. PMID: 31911610 Free PMC article.
Vertical transmission accounts for most human immunodeficiency virus (HIV) infection in children, and treatments for newborns are needed to abrogate infection or limit disease progression. We showed previously that short-term broadly neutralizing antibody (bNAb) therapy gi …
Vertical transmission accounts for most human immunodeficiency virus (HIV) infection in children, and treatments for newborns are needed to …
Stabilization and formulation of a recombinant Human Cytomegalovirus vector for use as a candidate HIV-1 vaccine.
Kumru OS, Saleh-Birdjandi S, Antunez LR, Sayeed E, Robinson D, van den Worm S, Diemer GS, Perez W, Caposio P, Früh K, Joshi SB, Volkin DB. Kumru OS, et al. Vaccine. 2019 Oct 16;37(44):6696-6706. doi: 10.1016/j.vaccine.2019.09.027. Epub 2019 Sep 20. Vaccine. 2019. PMID: 31548012 Free PMC article.
Thus, the goal of this work was to develop candidate frozen liquid formulations of rHCMV-1 with improved freeze-thaw and short-term liquid stability for potential use in early clinical trials. ...This case study highlights the utility of semi-empirical design of frozen liq …
Thus, the goal of this work was to develop candidate frozen liquid formulations of rHCMV-1 with improved freeze-thaw and short-term l …
Small-Molecule Probes Reveal Esterases with Persistent Activity in Dormant and Reactivating Mycobacterium tuberculosis.
Tallman KR, Levine SR, Beatty KE. Tallman KR, et al. ACS Infect Dis. 2016 Dec 9;2(12):936-944. doi: 10.1021/acsinfecdis.6b00135. Epub 2016 Oct 13. ACS Infect Dis. 2016. PMID: 27690385 Free PMC article.
These asymptomatic, latent infections impede tuberculosis eradication due to the long-term potential for reactivation. Dormant Mtb has reduced enzymatic activity, but hydrolases that remain active facilitate pathogen survival. ...
These asymptomatic, latent infections impede tuberculosis eradication due to the long-term potential for reactivation. Dormant Mtb ha …
Age-related dysregulation of CD8+ T cell memory specific for a persistent virus is independent of viral replication.
Lang A, Brien JD, Messaoudi I, Nikolich-Zugich J. Lang A, et al. J Immunol. 2008 Apr 1;180(7):4848-57. doi: 10.4049/jimmunol.180.7.4848. J Immunol. 2008. PMID: 18354208 Free PMC article.
But neither the causality nor the mechanistic link(s) were established, and the relative roles of persistent antigenic stimulation and of virus-independent homeostatic disturbances in T cell aging remain unresolved. We longitudinally analyzed expansion, contraction, and long-t …
But neither the causality nor the mechanistic link(s) were established, and the relative roles of persistent antigenic stimulation and of vi …
Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates.
Messaoudi I, Warner J, Fischer M, Park B, Hill B, Mattison J, Lane MA, Roth GS, Ingram DK, Picker LJ, Douek DC, Mori M, Nikolich-Zugich J. Messaoudi I, et al. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19448-53. doi: 10.1073/pnas.0606661103. Epub 2006 Dec 11. Proc Natl Acad Sci U S A. 2006. PMID: 17159149 Free PMC article.
Previous studies involving 2- to 4-year CR treatment of long-lived primates failed to find a CR effect or reported effects on the immune system opposite to those seen in CR-treated rodents. Here we show that long-term CR delays the adverse effects of aging on nonhuman prim …
Previous studies involving 2- to 4-year CR treatment of long-lived primates failed to find a CR effect or reported effects on the immune sys …