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Drugs Targeting Mechanisms of Aging to Delay Age-Related Disease and Promote Healthspan: Proceedings of a National Institute on Aging Workshop.
Espinoza SE, Khosla S, Baur JA, de Cabo R, Musi N. Espinoza SE, et al. J Gerontol A Biol Sci Med Sci. 2023 Jun 16;78(Suppl 1):53-60. doi: 10.1093/gerona/glad034. J Gerontol A Biol Sci Med Sci. 2023. PMID: 37325957
However, much further research is needed to demonstrate benefits and general safety for wider use, the appropriate target populations, and longer-term outcomes....
However, much further research is needed to demonstrate benefits and general safety for wider use, the appropriate target populations, and l …
TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy.
Levy SA, Zuniga G, Gonzalez EM, Butler D, Temple S, Frost B. Levy SA, et al. Cell Rep Methods. 2022 Sep 9;2(9):100292. doi: 10.1016/j.crmeth.2022.100292. eCollection 2022 Sep 19. Cell Rep Methods. 2022. PMID: 36160048 Free PMC article.
In the current study, we develop a Drosophila split-luciferase-based sensor of tau-tau interaction. This model, which we term "tau(LUM)," allows investigators to quantify tau multimerization at individual time points or longitudinally in adult, living animals housed in a 9 …
In the current study, we develop a Drosophila split-luciferase-based sensor of tau-tau interaction. This model, which we term "tau(LU …
Local immune responses to tuberculin skin challenge in Mycobacterium bovis BCG-vaccinated baboons: a pilot study of younger and older animals.
Scordo JM, Piergallini TJ, Reuter N, Headley CA, Hodara VL, Gonzalez O, Giavedoni LD, Papin JF, Turner J. Scordo JM, et al. Immun Ageing. 2021 Apr 7;18(1):16. doi: 10.1186/s12979-021-00229-w. Immun Ageing. 2021. PMID: 33827617 Free PMC article.
Vaccination generates BCG-specific immune cells that are recruited to the skin upon tuberculin challenge. We tested short term recall responses (8 weeks post-vaccination) and long term recall responses (25 weeks post-vaccination) by performing skin punch biopsies ar …
Vaccination generates BCG-specific immune cells that are recruited to the skin upon tuberculin challenge. We tested short term recall …
Rapamycin enhances BCG-specific γδ T cells during intravesical BCG therapy for non-muscle invasive bladder cancer: a randomized, double-blind study.
Ji N, Mukherjee N, Reyes RM, Gelfond J, Javors M, Meeks JJ, McConkey DJ, Shu ZJ, Ramamurthy C, Dennett R, Curiel TJ, Svatek RS. Ji N, et al. J Immunother Cancer. 2021 Mar;9(3):e001941. doi: 10.1136/jitc-2020-001941. J Immunother Cancer. 2021. PMID: 33653802 Free PMC article. Clinical Trial.
Rapamycin enhances BCG-specific gammadelta T cell immunity and boosts urinary cytokines during BCG treatment. Further study is needed to determine long-term rapamycin safety, tolerability and effects on BCG efficacy....
Rapamycin enhances BCG-specific gammadelta T cell immunity and boosts urinary cytokines during BCG treatment. Further study is needed to det …
Prenatal metformin exposure or organic cation transporter 3 knock-out curbs social interaction preference in male mice.
Garbarino VR, Santos TA, Nelson AR, Zhang WQ, Smolik CM, Javors MA, Daws LC, Gould GG. Garbarino VR, et al. Pharmacol Res. 2019 Feb;140:21-32. doi: 10.1016/j.phrs.2018.11.013. Epub 2018 Nov 10. Pharmacol Res. 2019. PMID: 30423430 Free PMC article.
Yet safety concerns regarding gestational metformin use remain, as its long-term effects in offspring are unclear. In light of beneficial findings with metformin for adult mouse social behavior, we hypothesized gestational metformin treatment might also promote offspring s …
Yet safety concerns regarding gestational metformin use remain, as its long-term effects in offspring are unclear. In light of benefi …
A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects.
Kraig E, Linehan LA, Liang H, Romo TQ, Liu Q, Wu Y, Benavides AD, Curiel TJ, Javors MA, Musi N, Chiodo L, Koek W, Gelfond JAL, Kellogg DL Jr. Kraig E, et al. Exp Gerontol. 2018 May;105:53-69. doi: 10.1016/j.exger.2017.12.026. Epub 2018 Feb 3. Exp Gerontol. 2018. PMID: 29408453 Free PMC article. Clinical Trial.
Thus, based on the results of our pilot study, it appears that short-term RAPA treatment can be used safely in older persons who are otherwise healthy; a trial with a larger sample size and longer treatment duration is warranted....
Thus, based on the results of our pilot study, it appears that short-term RAPA treatment can be used safely in older persons who are …
Theta-burst LTP.
Larson J, Munkácsy E. Larson J, et al. Brain Res. 2015 Sep 24;1621:38-50. doi: 10.1016/j.brainres.2014.10.034. Epub 2014 Oct 27. Brain Res. 2015. PMID: 25452022 Free PMC article. Review.
This review covers the spatial and temporal rules governing induction of hippocampal long-term potentiation (LTP) by theta-burst stimulation. Induction of LTP in field CA1 by high frequency stimulation bursts that resemble the burst discharges (complex-spikes) of hippocamp …
This review covers the spatial and temporal rules governing induction of hippocampal long-term potentiation (LTP) by theta-burst stim …
Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome.
Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Pérez VI, Richardson A. Fok WC, et al. PLoS One. 2014 Jan 7;9(1):e83988. doi: 10.1371/journal.pone.0083988. eCollection 2014. PLoS One. 2014. PMID: 24409289 Free PMC article.
Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways that could be responsible …
Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazar …
11 results