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Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device.
Olgasi C, Borsotti C, Merlin S, Bergmann T, Bittorf P, Adewoye AB, Wragg N, Patterson K, Calabria A, Benedicenti F, Cucci A, Borchiellini A, Pollio B, Montini E, Mazzuca DM, Zierau M, Stolzing A, Toleikis PM, Braspenning J, Follenzi A. Olgasi C, et al. Among authors: stolzing a. Mol Ther Methods Clin Dev. 2021 Nov 3;23:551-566. doi: 10.1016/j.omtm.2021.10.015. eCollection 2021 Dec 10. Mol Ther Methods Clin Dev. 2021. PMID: 34853801 Free PMC article.
As current therapies based on frequent FVIII infusions are not a definitive cure, long-term expression of FVIII in endothelial cells through lentiviral vector (LV)-mediated gene transfer holds the promise of a one-time treatment. ...Overall, this is the first preclinical s …
As current therapies based on frequent FVIII infusions are not a definitive cure, long-term expression of FVIII in endothelial cells …
Dissecting primary and secondary senescence to enable new senotherapeutic strategies.
Admasu TD, Rae M, Stolzing A. Admasu TD, et al. Among authors: stolzing a. Ageing Res Rev. 2021 Sep;70:101412. doi: 10.1016/j.arr.2021.101412. Epub 2021 Jul 21. Ageing Res Rev. 2021. PMID: 34302996 Review.
More recently, investigators have discovered that senescent cells induced by these methods (what we term "primary senescent cells") are also capable of inducing other non-senescent cells to undergo senescence - a phenomenon we call "secondary senescence." ...Second, primar …
More recently, investigators have discovered that senescent cells induced by these methods (what we term "primary senescent cells") a …
Stem cells in degenerative orthopaedic pathologies: effects of aging on therapeutic potential.
Atesok K, Fu FH, Sekiya I, Stolzing A, Ochi M, Rodeo SA. Atesok K, et al. Among authors: stolzing a. Knee Surg Sports Traumatol Arthrosc. 2017 Feb;25(2):626-636. doi: 10.1007/s00167-015-3763-9. Epub 2015 Aug 23. Knee Surg Sports Traumatol Arthrosc. 2017. PMID: 26298714 Review.
The studies published in English have been assessed, and the best and most recent evidence was included in the current study. RESULTS: Evidence suggests that, although short-term results regarding the effects of stem cell therapy in degenerative orthopaedic pathologies can …
The studies published in English have been assessed, and the best and most recent evidence was included in the current study. RESULTS: Evide …
Effect of different freezing rates during cryopreservation of rat mesenchymal stem cells using combinations of hydroxyethyl starch and dimethylsulfoxide.
Naaldijk Y, Staude M, Fedorova V, Stolzing A. Naaldijk Y, et al. Among authors: stolzing a. BMC Biotechnol. 2012 Aug 13;12:49. doi: 10.1186/1472-6750-12-49. BMC Biotechnol. 2012. PMID: 22889198 Free PMC article.
Cryopreservation is the most effective way to preserve cells long term, but it involves potentially cytotoxic compounds and processing steps. ...
Cryopreservation is the most effective way to preserve cells long term, but it involves potentially cytotoxic compounds and processin …
Effect of reduced culture temperature on antioxidant defences of mesenchymal stem cells.
Stolzing A, Scutt A. Stolzing A, et al. Free Radic Biol Med. 2006 Jul 15;41(2):326-38. doi: 10.1016/j.freeradbiomed.2006.04.018. Epub 2006 May 12. Free Radic Biol Med. 2006. PMID: 16814114
These data demonstrate that culturing MSC at reduced temperature decreases the accumulation of oxidative damage and therefore would probably improve long-term viability and successful engraftment of MSC used for tissue engineering or cell therapeutic purposes....
These data demonstrate that culturing MSC at reduced temperature decreases the accumulation of oxidative damage and therefore would probably …