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Cognition and the course of prodromal Parkinson's disease.
Weintraub D, Chahine LM, Hawkins KA, Siderowf A, Eberly S, Oakes D, Seibyl J, Stern MB, Marek K, Jennings D; PARS Investigators. Weintraub D, et al. Among authors: stern mb. Mov Disord. 2017 Nov;32(11):1640-1645. doi: 10.1002/mds.27189. Epub 2017 Oct 24. Mov Disord. 2017. PMID: 29063713 Free PMC article.
CONCLUSIONS: Given hyposmia in the general population predicts cognitive decline, the role of cognition in predicting conversion in prodromal PD needs to be assessed in large cohorts followed long-term. The dopamine system may be associated with changes in processing speed …
CONCLUSIONS: Given hyposmia in the general population predicts cognitive decline, the role of cognition in predicting conversion in prodroma …
Plasma EGF and cognitive decline in Parkinson's disease and Alzheimer's disease.
Lim NS, Swanson CR, Cherng HR, Unger TL, Xie SX, Weintraub D, Marek K, Stern MB, Siderowf A; PARS Investigators; Alzheimer's Disease Neuroimaging Initiative; Trojanowski JQ, Chen-Plotkin AS. Lim NS, et al. Among authors: stern mb. Ann Clin Transl Neurol. 2016 Mar 29;3(5):346-55. doi: 10.1002/acn3.299. eCollection 2016 May. Ann Clin Transl Neurol. 2016. PMID: 27231704 Free PMC article.
RESULTS: In both PD and AD-MCI, low baseline plasma EGF predicted poorer long-term cognitive outcomes. In asymptomatic individuals at highest risk for developing PD from the PARS cohort, low baseline plasma EGF associated with poorer performance in the visuospatial domain …
RESULTS: In both PD and AD-MCI, low baseline plasma EGF predicted poorer long-term cognitive outcomes. In asymptomatic individuals at …
Rasagiline in Parkinson's disease.
Chahine LM, Stern MB. Chahine LM, et al. Among authors: stern mb. Int Rev Neurobiol. 2011;100:151-68. doi: 10.1016/B978-0-12-386467-3.00008-X. Int Rev Neurobiol. 2011. PMID: 21971007 Review.
Clinical trials have also shown putative disease-modifying effects, though rasagiline's potential to alter the long-term course of PD remains controversial. Given the demonstrated benefits of rasagiline, along with its safety and tolerability profile, it has an important r …
Clinical trials have also shown putative disease-modifying effects, though rasagiline's potential to alter the long-term course of PD …
Parkinson's at risk syndrome: can Parkinson's disease be predicted?
Stern MB, Siderowf A. Stern MB, et al. Mov Disord. 2010;25 Suppl 1:S89-93. doi: 10.1002/mds.22719. Mov Disord. 2010. PMID: 20187248
Our approach to PD must therefore evolve and include strategies for detecting PD earlier in its course and, eventually, intervening when the disease process is in its nascent stages. Parkinson's associated risk syndrome (PARS) is the term we have coined to describe patient …
Our approach to PD must therefore evolve and include strategies for detecting PD earlier in its course and, eventually, intervening when the …
Use of latent variable modeling to delineate psychiatric and cognitive profiles in Parkinson disease.
Mavandadi S, Nazem S, Ten Have TR, Siderowf AD, Duda JE, Stern MB, Weintraub D. Mavandadi S, et al. Among authors: stern mb. Am J Geriatr Psychiatry. 2009 Nov;17(11):986-95. doi: 10.1097/JGP.0b013e3181b215ec. Am J Geriatr Psychiatry. 2009. PMID: 19855199 Free PMC article.
Neuropsychiatric symptoms and cognitive deficits follow distinct patterns in PD, and further study is needed to determine whether these classes are generalizable, stable, predict function, quality of life, and long-term outcomes and are amenable to treatment at a class lev …
Neuropsychiatric symptoms and cognitive deficits follow distinct patterns in PD, and further study is needed to determine whether these clas …
Long-term follow-up of impulse control disorders in Parkinson's disease.
Mamikonyan E, Siderowf AD, Duda JE, Potenza MN, Horn S, Stern MB, Weintraub D. Mamikonyan E, et al. Among authors: stern mb. Mov Disord. 2008 Jan;23(1):75-80. doi: 10.1002/mds.21770. Mov Disord. 2008. PMID: 17960796 Free PMC article.
Little is known about optimal management strategies or the long-term outcomes of affected patients. To report on the clinical interventions and long-term outcomes of PD patients who developed an ICD after DA initiation. ...
Little is known about optimal management strategies or the long-term outcomes of affected patients. To report on the clinical interve …
Long-term outcomes of bilateral subthalamic nucleus stimulation in patients with advanced Parkinson's disease.
Liang GS, Chou KL, Baltuch GH, Jaggi JL, Loveland-Jones C, Leng L, Maccarone H, Hurtig HI, Colcher A, Stern MB, Kleiner-Fisman G, Simuni T, Siderowf AD. Liang GS, et al. Among authors: stern mb. Stereotact Funct Neurosurg. 2006;84(5-6):221-7. doi: 10.1159/000096495. Epub 2006 Oct 23. Stereotact Funct Neurosurg. 2006. PMID: 17063043
BACKGROUND: In patients with advanced Parkinson's disease (PD), deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been shown to improve motor function and decrease medication requirements in the short term. However, the long-term benefits of DBS are …
BACKGROUND: In patients with advanced Parkinson's disease (PD), deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been shown …
Bilateral stimulation of the subthalamic nucleus in patients with Parkinson disease: a study of efficacy and safety.
Simuni T, Jaggi JL, Mulholland H, Hurtig HI, Colcher A, Siderowf AD, Ravina B, Skolnick BE, Goldstein R, Stern MB, Baltuch GH. Simuni T, et al. Among authors: stern mb. J Neurosurg. 2002 Apr;96(4):666-72. doi: 10.3171/jns.2002.96.4.0666. J Neurosurg. 2002. PMID: 11990805 Clinical Trial.
OBJECT: Palliative neurosurgery has reemerged as a valid therapy for patients with advanced Parkinson disease (PD) that is complicated by severe motor fluctuations. Despite great enthusiasm for long-term deep brain stimulation (DBS) of the subthalamic nucleus (STN), existi …
OBJECT: Palliative neurosurgery has reemerged as a valid therapy for patients with advanced Parkinson disease (PD) that is complicated by se …
Emergence of complex, involuntary movements after gamma knife radiosurgery for essential tremor.
Siderowf A, Gollump SM, Stern MB, Baltuch GH, Riina HA. Siderowf A, et al. Among authors: stern mb. Mov Disord. 2001 Sep;16(5):965-7. doi: 10.1002/mds.1178. Mov Disord. 2001. PMID: 11746633
We report the case of a 59-year-old patient with essential tremor who developed a complex, disabling movement disorder following gamma knife thalamotomy. This case illustrates the need for long-term follow-up to fully evaluate the potential for complications following radi …
We report the case of a 59-year-old patient with essential tremor who developed a complex, disabling movement disorder following gamma knife …
Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation.
During MJ, Kaplitt MG, Stern MB, Eidelberg D. During MJ, et al. Among authors: stern mb. Hum Gene Ther. 2001 Aug 10;12(12):1589-91. Hum Gene Ther. 2001. PMID: 11529246 Clinical Trial.
These showed some encouraging effects on dopamine neuron survival and regeneration in both rodent and primate models; however, uncertain consequences of long-term growth factor expression and question regarding timing of therapy in the disease course must be resolved befor …
These showed some encouraging effects on dopamine neuron survival and regeneration in both rodent and primate models; however, uncertain con …
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