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Increased intraindividual variability in reaction time performance is associated with emerging cognitive decline in cognitively unimpaired adults.
Jutten RJ, Amariglio RE, Maruff P, Properzi MJ, Rentz DM, Johnson KA, Sperling RA, Papp KV. Jutten RJ, et al. Among authors: sperling ra. Neuropsychology. 2024 Feb;38(2):184-197. doi: 10.1037/neu0000928. Epub 2023 Nov 16. Neuropsychology. 2024. PMID: 37971861
CONCLUSIONS: Increased variability in monthly RT may reflect subtle EF deficits and provide unique information about short-term cognitive decline in preclinical Alzheimer's disease. (PsycInfo Database Record (c) 2024 APA, all rights reserved)....
CONCLUSIONS: Increased variability in monthly RT may reflect subtle EF deficits and provide unique information about short-term cogni …
Cortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid.
Gagliardi G, Rodriguez-Vieitez E, Montal V, Sepulcre J, Diez I, Lois C, Hanseeuw B, Schultz AP, Properzi MJ, Papp KV, Marshall GA, Fortea J, Johnson KA, Sperling RA, Vannini P. Gagliardi G, et al. Among authors: sperling ra. Commun Med (Lond). 2023 Aug 1;3(1):106. doi: 10.1038/s43856-023-00324-7. Commun Med (Lond). 2023. PMID: 37528163 Free PMC article.
CONCLUSIONS: The combination of amyloidosis and elevated cMD in the entorhinal cortex may help identify individuals at short-term risk of tau accumulation and Alzheimer's Disease-related episodic memory decline, suggesting utility in clinical trials. ...
CONCLUSIONS: The combination of amyloidosis and elevated cMD in the entorhinal cortex may help identify individuals at short-term ris …
Computerized cognitive practice effects in relation to amyloid and tau in preclinical Alzheimer's disease: Results from a multi-site cohort.
Young CB, Mormino EC, Poston KL, Johnson KA, Rentz DM, Sperling RA, Papp KV. Young CB, et al. Among authors: sperling ra. Alzheimers Dement (Amst). 2023 Mar 20;15(1):e12414. doi: 10.1002/dad2.12414. eCollection 2023 Jan-Mar. Alzheimers Dement (Amst). 2023. PMID: 36950699 Free PMC article.
Initial C3 performance was associated with amyloid status across all participants, and with tau burden in the medial temporal lobe and early cortical regions in CU with abnormal amyloid. Short-term practice effects were associated with reduced tau in these regions in CU wi …
Initial C3 performance was associated with amyloid status across all participants, and with tau burden in the medial temporal lobe and early …
Tau positron emission tomography in preclinical Alzheimer's disease.
Insel PS, Young CB, Aisen PS, Johnson KA, Sperling RA, Mormino EC, Donohue MC. Insel PS, et al. Among authors: sperling ra. Brain. 2023 Feb 13;146(2):700-711. doi: 10.1093/brain/awac299. Brain. 2023. PMID: 35962782 Free PMC article.
However, these abnormal levels do not appear to be the result of a high rate of accumulation in the short term, but possibly a more moderate rate occurring early with respect to age. ...
However, these abnormal levels do not appear to be the result of a high rate of accumulation in the short term, but possibly a more m …
Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment.
Strikwerda-Brown C, Hobbs DA, Gonneaud J, St-Onge F, Binette AP, Ozlen H, Provost K, Soucy JP, Buckley RF, Benzinger TLS, Morris JC, Villemagne VL, Doré V, Sperling RA, Johnson KA, Rowe CC, Gordon BA, Poirier J, Breitner JCS, Villeneuve S; PREVENT-AD, HABS, and AIBL Research Groups. Strikwerda-Brown C, et al. Among authors: sperling ra. JAMA Neurol. 2022 Oct 1;79(10):975-985. doi: 10.1001/jamaneurol.2022.2379. JAMA Neurol. 2022. PMID: 35907254 Free PMC article.
OBJECTIVE: To assess the clinical value of these biological criteria to identify older individuals without cognitive impairment who are at near-term risk of developing symptomatic AD. DESIGN, SETTING, AND PARTICIPANTS: This longitudinal cohort study used data from 4 indepe …
OBJECTIVE: To assess the clinical value of these biological criteria to identify older individuals without cognitive impairment who are at n …
Meaningful benefits: a framework to assess disease-modifying therapies in preclinical and early Alzheimer's disease.
Assunção SS, Sperling RA, Ritchie C, Kerwin DR, Aisen PS, Lansdall C, Atri A, Cummings J. Assunção SS, et al. Among authors: sperling ra. Alzheimers Res Ther. 2022 Apr 19;14(1):54. doi: 10.1186/s13195-022-00984-y. Alzheimers Res Ther. 2022. PMID: 35440022 Free PMC article. Review.
The meaningful benefits framework applies to data collection, assessment, and communication across three dimensions: (1) multidimensional clinical outcome assessments (COAs) including not only core disease outcomes related to cognition and function but also patient- and caregiver …
The meaningful benefits framework applies to data collection, assessment, and communication across three dimensions: (1) multidimensional cl …
Visual short-term memory relates to tau and amyloid burdens in preclinical autosomal dominant Alzheimer's disease.
Norton DJ, Parra MA, Sperling RA, Baena A, Guzman-Velez E, Jin DS, Andrea N, Khang J, Schultz A, Rentz DM, Pardilla-Delgado E, Fuller J, Johnson K, Reiman EM, Lopera F, Quiroz YT. Norton DJ, et al. Among authors: sperling ra. Alzheimers Res Ther. 2020 Aug 21;12(1):99. doi: 10.1186/s13195-020-00660-z. Alzheimers Res Ther. 2020. PMID: 32825838 Free PMC article.
BACKGROUND: Over the past decade, visual short-term memory (VSTM) binding tests have been shown to be one of the most sensitive behavioral indicators of Alzheimer's disease (AD), especially when they require the binding of multiple features (e.g., color and shape). ...
BACKGROUND: Over the past decade, visual short-term memory (VSTM) binding tests have been shown to be one of the most sensitive behav …
Short-term Psychological Outcomes of Disclosing Amyloid Imaging Results to Research Participants Who Do Not Have Cognitive Impairment.
Grill JD, Raman R, Ernstrom K, Sultzer DL, Burns JM, Donohue MC, Johnson KA, Aisen PS, Sperling RA, Karlawish J; A4 Study Team. Grill JD, et al. Among authors: sperling ra. JAMA Neurol. 2020 Dec 1;77(12):1504-1513. doi: 10.1001/jamaneurol.2020.2734. JAMA Neurol. 2020. PMID: 32777010 Free PMC article. Clinical Trial.
IMPORTANCE: The goal of preclinical Alzheimer disease (AD) clinical trials is to move diagnosis and treatment to presymptomatic stages, which will require biomarker testing and disclosure. OBJECTIVE: To assess the short-term psychological outcomes of disclosing amyloid pos …
IMPORTANCE: The goal of preclinical Alzheimer disease (AD) clinical trials is to move diagnosis and treatment to presymptomatic stages, whic …
Subjective cognitive concerns are associated with objective memory performance in Caucasian but not African-American persons.
Jackson JD, Rentz DM, Aghjayan SL, Buckley RF, Meneide TF, Sperling RA, Amariglio RE. Jackson JD, et al. Among authors: sperling ra. Age Ageing. 2017 Nov 1;46(6):988-993. doi: 10.1093/ageing/afx077. Age Ageing. 2017. PMID: 29088363 Free PMC article.
No group differences were observed in the matched sample. The SCC race interaction term was nonsignificant in the full sample, beta = 0.109, P = 0.09, but was significant in the matched sample, beta = 0.422, P = 0.037. ...
No group differences were observed in the matched sample. The SCC race interaction term was nonsignificant in the full sample, beta = …
25 results