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Development of a Rat Model of Fasciotomy Treatment for Compartment Syndrome.
Poteracki JM, Moschouris K, Yoseph BP, Zhou Y, Soker S, Criswell TL. Poteracki JM, et al. Among authors: soker s. Tissue Eng Part C Methods. 2022 Feb;28(2):51-60. doi: 10.1089/ten.TEC.2021.0205. Tissue Eng Part C Methods. 2022. PMID: 35107365 Free PMC article.
Early fasciotomy will preserve the limb, but often leaves patients with long-term scarring and reduced muscle function. Our group previously developed and characterized a rat model of CS to explore the pathophysiology of CS and test new therapies. ...
Early fasciotomy will preserve the limb, but often leaves patients with long-term scarring and reduced muscle function. Our group pre …
Pleural Effusion Aspirate for Use in 3D Lung Cancer Modeling and Chemotherapy Screening.
Mazzocchi A, Dominijanni A, Soker S. Mazzocchi A, et al. Among authors: soker s. Methods Mol Biol. 2022;2394:471-483. doi: 10.1007/978-1-0716-1811-0_24. Methods Mol Biol. 2022. PMID: 35094341
Here, we discuss the fabrication of 3D lung cancer organoids using a rare cell source, pleural effusion aspirate. We tracked the phenotypic change that developed in short-term culturing and characterized the cell population within the organoids. ...
Here, we discuss the fabrication of 3D lung cancer organoids using a rare cell source, pleural effusion aspirate. We tracked the phenotypic …
Drug compound screening in single and integrated multi-organoid body-on-a-chip systems.
Skardal A, Aleman J, Forsythe S, Rajan S, Murphy S, Devarasetty M, Pourhabibi Zarandi N, Nzou G, Wicks R, Sadri-Ardekani H, Bishop C, Soker S, Hall A, Shupe T, Atala A. Skardal A, et al. Among authors: soker s. Biofabrication. 2020 Feb 26;12(2):025017. doi: 10.1088/1758-5090/ab6d36. Biofabrication. 2020. PMID: 32101533
These integrated systems proved to maintain viability and expressed functional biomarkers, long-term. Examples are provided that demonstrate how multi-organoid 'body-on-a-chip' systems may be used to model the interdependent metabolism and downstream effects of drugs acros …
These integrated systems proved to maintain viability and expressed functional biomarkers, long-term. Examples are provided that demo …
N-Acetyl-L-Cysteine Reduces Fibrosis and Improves Muscle Function After Acute Compartment Syndrome Injury.
Yosef B, Zhou Y, Mouschouris K, Poteracki J, Soker S, Criswell T. Yosef B, et al. Among authors: soker s. Mil Med. 2020 Jan 7;185(Suppl 1):25-34. doi: 10.1093/milmed/usz232. Mil Med. 2020. PMID: 32074330 Free PMC article.
CONCLUSIONS: These results suggest that NAC treatment of skeletal muscle after injury may be a viable option for the prevention of long-term fibrosis and scar formation, facilitating recovery of muscle function....
CONCLUSIONS: These results suggest that NAC treatment of skeletal muscle after injury may be a viable option for the prevention of long-t …
Pleural Effusion Aspirate for use in 3D Lung Cancer Modeling and Chemotherapy Screening.
Mazzocchi A, Devarasetty M, Herberg S, Petty WJ, Marini F, Miller L, Kucera G, Dukes DK, Ruiz J, Skardal A, Soker S. Mazzocchi A, et al. Among authors: soker s. ACS Biomater Sci Eng. 2019 Apr 8;5(4):1937-1943. doi: 10.1021/acsbiomaterials.8b01356. Epub 2019 Mar 8. ACS Biomater Sci Eng. 2019. PMID: 31723594 Free PMC article.
With these 3D models, we have characterized the cell populations comprising the pleural effusion aspirate and have tracked phenotypic changes that develop during short-term in vitro culture. We found that isolated, patient cells placed directly into organoids created anato …
With these 3D models, we have characterized the cell populations comprising the pleural effusion aspirate and have tracked phenotypic change …
Development of a Colorectal Cancer 3D Micro-tumor Construct Platform From Cell Lines and Patient Tumor Biospecimens for Standard-of-Care and Experimental Drug Screening.
Forsythe S, Mehta N, Devarasetty M, Sivakumar H, Gmeiner W, Soker S, Votanopoulos K, Skardal A. Forsythe S, et al. Among authors: soker s. Ann Biomed Eng. 2020 Mar;48(3):940-952. doi: 10.1007/s10439-019-02269-2. Epub 2019 Apr 24. Ann Biomed Eng. 2020. PMID: 31020445 Free PMC article.
In this study, we utilized an extracellular matrix-derived hydrogel to create a 3D micro-tumor construct platform capable of both supporting cells for long time durations and for high throughput drug screening. Experiments with cell lines demonstrated long-term viability w …
In this study, we utilized an extracellular matrix-derived hydrogel to create a 3D micro-tumor construct platform capable of both supporting …
In Vitro Proliferation of Porcine Pancreatic Islet Cells for β-Cell Therapy Applications.
Niu G, McQuilling JP, Zhou Y, Opara EC, Orlando G, Soker S. Niu G, et al. Among authors: soker s. J Diabetes Res. 2016;2016:5807876. doi: 10.1155/2016/5807876. Epub 2016 Dec 6. J Diabetes Res. 2016. PMID: 28050568 Free PMC article.
beta-Cell replacement through transplantation is the only curative treatment to establish a long-term stable euglycemia in diabetic patients. Owing to the shortage of donor tissue, attempts are being made to develop alternative sources of insulin-secreting cells. ...
beta-Cell replacement through transplantation is the only curative treatment to establish a long-term stable euglycemia in diabetic p …
A tunable hydrogel system for long-term release of cell-secreted cytokines and bioprinted in situ wound cell delivery.
Skardal A, Murphy SV, Crowell K, Mack D, Atala A, Soker S. Skardal A, et al. Among authors: soker s. J Biomed Mater Res B Appl Biomater. 2017 Oct;105(7):1986-2000. doi: 10.1002/jbm.b.33736. Epub 2016 Jun 28. J Biomed Mater Res B Appl Biomater. 2017. PMID: 27351939 Free PMC article.
Often, delivered cells are transient, and half-lives of the growth factors that they secrete are short, limiting their long-term effectiveness. The goal of this study was to optimize a hydrogel system capable of in situ cell delivery that could sequester and release growth …
Often, delivered cells are transient, and half-lives of the growth factors that they secrete are short, limiting their long-term effe …
Bioengineered multilayered human corneas from discarded human corneal tissue.
Zhang Z, Niu G, Choi JS, Giegengack M, Atala A, Soker S. Zhang Z, et al. Among authors: soker s. Biomed Mater. 2015 Jun 24;10(3):035012. doi: 10.1088/1748-6041/10/3/035012. Biomed Mater. 2015. PMID: 26106974
These constructs may be suitable for corneal transplantation, and as a short-term application, may serve for ophthalmological drug testing purposes....
These constructs may be suitable for corneal transplantation, and as a short-term application, may serve for ophthalmological drug te …
An in vitro culture system that supports robust expansion and maintenance of in vivo engraftment capabilities for myogenic progenitor cells from adult mice.
Wang Z, Cheung D, Zhou Y, Han C, Fennelly C, Criswell T, Soker S. Wang Z, et al. Among authors: soker s. Biores Open Access. 2014 Jun 1;3(3):79-87. doi: 10.1089/biores.2014.0007. Biores Open Access. 2014. PMID: 24940559 Free PMC article.
In the current study, we developed an in vitro system that allowed for long-term culture and massive expansion of murine MPCs (mMPCs) with the preservation of myogenic regeneration capabilities. Long term in vitro expanded mMPC expressed the myogenic stem cell marke …
In the current study, we developed an in vitro system that allowed for long-term culture and massive expansion of murine MPCs (mMPCs) …
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