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Escape from G1 arrest during acute MEK inhibition drives the acquisition of drug resistance.
Channathodiyil P, May K, Segonds-Pichon A, Smith PD, Cook SJ, Houseley J. Channathodiyil P, et al. Among authors: segonds pichon a. NAR Cancer. 2022 Oct 17;4(4):zcac032. doi: 10.1093/narcan/zcac032. eCollection 2022 Dec. NAR Cancer. 2022. PMID: 36267209 Free PMC article.
Here, we investigate BRAF(V600E) amplification events that underlie resistance to the MEK inhibitor selumetinib (AZD6244/ARRY-142886) in COLO205 cells, a well-characterized model for reproducible emergence of drug resistance, and show that BRAF amplifications acquired de novo are …
Here, we investigate BRAF(V600E) amplification events that underlie resistance to the MEK inhibitor selumetinib (AZD6244/ARRY-142886) in COL …
Changes in molecular epidemiology of streptococcus pneumoniae causing meningitis following introduction of pneumococcal conjugate vaccination in England and Wales.
Pichon B, Ladhani SN, Slack MP, Segonds-Pichon A, Andrews NJ, Waight PA, Miller E, George R. Pichon B, et al. Among authors: segonds pichon a. J Clin Microbiol. 2013 Mar;51(3):820-7. doi: 10.1128/JCM.01917-12. Epub 2012 Dec 26. J Clin Microbiol. 2013. PMID: 23269742 Free PMC article.
Thus, the introduction of PCV7 resulted in an increase in non-PCV7 serotypes, including some not covered by the 13-valent vaccine, such as serotypes 22F and 33F, emphasizing the importance of long-term epidemiological and molecular surveillance....
Thus, the introduction of PCV7 resulted in an increase in non-PCV7 serotypes, including some not covered by the 13-valent vaccine, such as s …