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Glycemic Variability As a Prognostic Factor for Mortality in Patients With Critical Illness: A Systematic Review and Meta-Analysis.
Hryciw BN, Ghossein J, Rochwerg B, Meggison H, Fernando SM, Kyeremanteng K, Tran A, Seely AJE. Hryciw BN, et al. Among authors: seely aje. Crit Care Explor. 2024 Jan 11;6(1):e1025. doi: 10.1097/CCE.0000000000001025. eCollection 2024 Jan. Crit Care Explor. 2024. PMID: 38222872 Free PMC article. Review.
STUDY SELECTION: We included English language studies that assessed metrics of glycemic variation or complexity and short-term mortality in patients admitted to the ICU. DATA EXTRACTION: Two authors performed independent data abstraction and risk-of-bias assessments. ...CO …
STUDY SELECTION: We included English language studies that assessed metrics of glycemic variation or complexity and short-term mortal …
Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis.
Fernando SM, Tran A, Sadeghirad B, Burns KEA, Fan E, Brodie D, Munshi L, Goligher EC, Cook DJ, Fowler RA, Herridge MS, Cardinal P, Jaber S, Møller MH, Thille AW, Ferguson ND, Slutsky AS, Brochard LJ, Seely AJE, Rochwerg B. Fernando SM, et al. Among authors: seely aje. Intensive Care Med. 2022 Feb;48(2):137-147. doi: 10.1007/s00134-021-06581-1. Epub 2021 Nov 25. Intensive Care Med. 2022. PMID: 34825256 Free article.
Compared to conventional oxygen therapy, neither NIPPV (OR 0.8 [95% CI 0.61-1.04], moderate certainty) or HFNC (OR 0.9 [95% CI 0.66-1.24], low certainty) reduced short-term mortality. Consistent findings were demonstrated across multiple subgroups, including high- and low- …
Compared to conventional oxygen therapy, neither NIPPV (OR 0.8 [95% CI 0.61-1.04], moderate certainty) or HFNC (OR 0.9 [95% CI 0.66-1.24], l …
Postoperative Adverse Events are Associated with Oncologic Recurrence Following Curative-intent Resection for Lung Cancer.
Gowing S, Baker L, Tran A, Zhang Z, Ahn H, Ivanovic J, Anstee C, Grigor E, Gilbert S, Maziak DE, Shamji F, Sundaresan S, Villeneuve PJ, Seely AJE. Gowing S, et al. Among authors: seely aje. Lung. 2020 Dec;198(6):973-981. doi: 10.1007/s00408-020-00395-6. Epub 2020 Oct 9. Lung. 2020. PMID: 33034720
BACKGROUND: Up to 50% of patients suffer short-term postoperative adverse events (AEs) and metastatic recurrence in the long-term following curative-intent lung cancer resection. ...
BACKGROUND: Up to 50% of patients suffer short-term postoperative adverse events (AEs) and metastatic recurrence in the long-term …
Long-term Symptom Control After Laparoscopic Heller Myotomy and Dor Fundoplication for Achalasia.
Doubova M, Gowing S, Robaidi H, Gilbert S, Maziak DE, Shamji FM, Sundaresan RS, Villeneuve PJ, Seely AJE. Doubova M, et al. Among authors: seely aje. Ann Thorac Surg. 2021 May;111(5):1717-1723. doi: 10.1016/j.athoracsur.2020.06.095. Epub 2020 Sep 3. Ann Thorac Surg. 2021. PMID: 32891651
A favored treatment is laparoscopic modified Heller myotomy with Dor fundoplication (LHMDor) with more than 90% immediate beneficial effect. The short-term outcomes of LHMDor are well documented, but stability and durability of postoperative symptom control over time is le …
A favored treatment is laparoscopic modified Heller myotomy with Dor fundoplication (LHMDor) with more than 90% immediate beneficial effect. …
Frailty and invasive mechanical ventilation: association with outcomes, extubation failure, and tracheostomy.
Fernando SM, McIsaac DI, Rochwerg B, Bagshaw SM, Muscedere J, Munshi L, Ferguson ND, Seely AJE, Cook DJ, Dave C, Tanuseputro P, Kyeremanteng K. Fernando SM, et al. Among authors: seely aje. Intensive Care Med. 2019 Dec;45(12):1742-1752. doi: 10.1007/s00134-019-05795-8. Epub 2019 Oct 8. Intensive Care Med. 2019. PMID: 31595352
The primary outcome was hospital mortality. Secondary outcomes included discharge to long-term care, extubation failure at time of first liberation attempt, and tracheostomy. ...CONCLUSIONS: The presence of frailty among patients receiving mechanical ventilation is associa …
The primary outcome was hospital mortality. Secondary outcomes included discharge to long-term care, extubation failure at time of fi …
Frailty and Associated Outcomes and Resource Utilization Among Older ICU Patients With Suspected Infection.
Fernando SM, McIsaac DI, Perry JJ, Rochwerg B, Bagshaw SM, Thavorn K, Seely AJE, Forster AJ, Fiest KM, Dave C, Tran A, Reardon PM, Tanuseputro P, Kyeremanteng K. Fernando SM, et al. Among authors: seely aje. Crit Care Med. 2019 Aug;47(8):e669-e676. doi: 10.1097/CCM.0000000000003831. Crit Care Med. 2019. PMID: 31135504
Frailty was also associated with higher likelihood of discharge to long-term care (adjusted odds ratio, 2.06 [95% CI, 1.50-2.64]) and higher likelihood of readmission within 30 days (adjusted odds ratio, 1.83 [95% CI, 1.38-2.34]). ...CONCLUSIONS: The presence of frailty am …
Frailty was also associated with higher likelihood of discharge to long-term care (adjusted odds ratio, 2.06 [95% CI, 1.50-2.64]) and …
Vagal contributions to fetal heart rate variability: an omics approach.
Herry CL, Burns P, Desrochers A, Fecteau G, Durosier LD, Cao M, Seely AJE, Frasch MG. Herry CL, et al. Among authors: seely aje. Physiol Meas. 2019 Jul 1;40(6):065004. doi: 10.1088/1361-6579/ab21ae. Physiol Meas. 2019. PMID: 31091517
We aimed to develop novel experimental and data analytical approaches to identify fHRV measures reflecting the vagus nerve contributions to fHRV. APPROACH: In near-term ovine fetuses, a comprehensive set of 46 fHRV measures was computed from fetal pre-cordial electrocardio …
We aimed to develop novel experimental and data analytical approaches to identify fHRV measures reflecting the vagus nerve contributions to …
Sepsis-3 Septic Shock Criteria and Associated Mortality Among Infected Hospitalized Patients Assessed by a Rapid Response Team.
Fernando SM, Reardon PM, Rochwerg B, Shapiro NI, Yealy DM, Seely AJE, Perry JJ, Barnaby DP, Murphy K, Tanuseputro P, Kyeremanteng K. Fernando SM, et al. Among authors: seely aje. Chest. 2018 Aug;154(2):309-316. doi: 10.1016/j.chest.2018.05.004. Epub 2018 May 17. Chest. 2018. PMID: 29778659

Patients meeting the Sepsis-3 septic shock criteria had higher in-hospital mortality (40.9% vs 33.5%; P < .0001), ICU admission (99.5% vs 89.2%; P < .001), and discharge rates to long-term care (66.3% vs 53.7%; P < .0001) than patients meeting the SIRS-based septi

…

Patients meeting the Sepsis-3 septic shock criteria had higher in-hospital mortality (40.9% vs 33.5%; P < .0001), ICU admission (99.5% vs

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Helpful Only When Elevated: Initial Serum Lactate in Stable Emergency Department Patients with Sepsis Is Specific, but Not Sensitive for Future Deterioration.
Fernando SM, Barnaby DP, Herry CL, Gallagher EJ, Shapiro NI, Seely AJE. Fernando SM, et al. Among authors: seely aje. J Emerg Med. 2018 Jun;54(6):766-773. doi: 10.1016/j.jemermed.2018.01.040. Epub 2018 Mar 13. J Emerg Med. 2018. PMID: 29548723
Lactate is associated with 28-day mortality in admitted patients, but little evidence exists on its use in predicting short-term deterioration. OBJECTIVE: Our aim was to determine the role of initial serum lactate for prediction of short-term deterioration in stable …
Lactate is associated with 28-day mortality in admitted patients, but little evidence exists on its use in predicting short-term dete …
Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection: A Systematic Review and Meta-analysis.
Fernando SM, Tran A, Taljaard M, Cheng W, Rochwerg B, Seely AJE, Perry JJ. Fernando SM, et al. Among authors: seely aje. Ann Intern Med. 2018 Feb 20;168(4):266-275. doi: 10.7326/M17-2820. Epub 2018 Feb 6. Ann Intern Med. 2018. PMID: 29404582
CONCLUSION: qSOFA had poor sensitivity and moderate specificity for short-term mortality. The SIRS criteria had sensitivity superior to that of qSOFA, supporting their use for screening of patients and as a prompt for treatment initiation. ...
CONCLUSION: qSOFA had poor sensitivity and moderate specificity for short-term mortality. The SIRS criteria had sensitivity superior …
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