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An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence.
Riviere-Cazaux C, Carlstrom LP, Neth BJ, Olson IE, Rajani K, Rahman M, Ikram S, Mansour MA, Mukherjee B, Warrington AE, Short SC, von Zglinicki T, Brown DA, Burma S, Tchkonia T, Schafer MJ, Baker DJ, Kizilbash SH, Kirkland JL, Burns TC. Riviere-Cazaux C, et al. Among authors: schafer mj. NPJ Precis Oncol. 2023 Nov 29;7(1):126. doi: 10.1038/s41698-023-00476-8. NPJ Precis Oncol. 2023. PMID: 38030881 Free PMC article. Review.
High-grade gliomas are primary brain tumors that are incredibly refractory long-term to surgery and chemoradiation, with no proven durable salvage therapies for patients that have failed conventional treatments. ...We also discuss how senescent cell clearance can decrease …
High-grade gliomas are primary brain tumors that are incredibly refractory long-term to surgery and chemoradiation, with no proven du …
Calorie restriction slows age-related microbiota changes in an Alzheimer's disease model in female mice.
Cox LM, Schafer MJ, Sohn J, Vincentini J, Weiner HL, Ginsberg SD, Blaser MJ. Cox LM, et al. Among authors: schafer mj. Sci Rep. 2019 Nov 29;9(1):17904. doi: 10.1038/s41598-019-54187-x. Sci Rep. 2019. PMID: 31784610 Free PMC article.
Furthermore, we demonstrate that Bacteroides colonization exacerbates Abeta deposition, which may be a mechanism whereby the gut impacts AD pathogenesis. These results suggest that long-term CR may alter the gut environment and prevent the expansion of microbes that contri …
Furthermore, we demonstrate that Bacteroides colonization exacerbates Abeta deposition, which may be a mechanism whereby the gut impacts AD …
Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.
Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK. Schafer MJ, et al. Diabetes. 2016 Jun;65(6):1606-15. doi: 10.2337/db15-0291. Epub 2016 Mar 16. Diabetes. 2016. PMID: 26983960 Free PMC article.
We show that exercise prevents the accumulation of senescent cells and the expression of the SASP while nullifying the damaging effects of the FFD on parameters of health. We also demonstrate that exercise initiated after long-term FFD feeding reduces senescent phenotype m …
We show that exercise prevents the accumulation of senescent cells and the expression of the SASP while nullifying the damaging effects of t …
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.
Roos CM, Zhang B, Palmer AK, Ogrodnik MB, Pirtskhalava T, Thalji NM, Hagler M, Jurk D, Smith LA, Casaclang-Verzosa G, Zhu Y, Schafer MJ, Tchkonia T, Kirkland JL, Miller JD. Roos CM, et al. Among authors: schafer mj. Aging Cell. 2016 Oct;15(5):973-7. doi: 10.1111/acel.12458. Epub 2016 Aug 5. Aging Cell. 2016. PMID: 26864908 Free PMC article.
While reports suggest a single dose of senolytics may improve vasomotor function, the structural and functional impact of long-term senolytic treatment is unknown. To determine whether long-term senolytic treatment improves vasomotor function, vascular stiffness, an …
While reports suggest a single dose of senolytics may improve vasomotor function, the structural and functional impact of long-term s …
Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional Signatures.
Schafer MJ, Dolgalev I, Alldred MJ, Heguy A, Ginsberg SD. Schafer MJ, et al. PLoS One. 2015 Jul 29;10(7):e0133923. doi: 10.1371/journal.pone.0133923. eCollection 2015. PLoS One. 2015. PMID: 26221964 Free PMC article.
However, the mosaic of molecular changes responsible for CR benefits remains unclear, particularly in brain regions susceptible to deterioration during aging. We examined the influence of long-term CR on the CA1 hippocampal region, a key learning and memory brain area that …
However, the mosaic of molecular changes responsible for CR benefits remains unclear, particularly in brain regions susceptible to deteriora …
Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice.
Schafer MJ, Alldred MJ, Lee SH, Calhoun ME, Petkova E, Mathews PM, Ginsberg SD. Schafer MJ, et al. Neurobiol Aging. 2015 Mar;36(3):1293-302. doi: 10.1016/j.neurobiolaging.2014.10.043. Epub 2014 Dec 4. Neurobiol Aging. 2015. PMID: 25556162 Free PMC article.
Sustained CR also significantly reduced expression of presenilin enhancer 2 (Psenen) and presenilin 1, components of the gamma-secretase complex, in Tg2576 females. These results indicate that long-term CR significantly reduces age-dependent female Tg2576 Abeta pathology, …
Sustained CR also significantly reduced expression of presenilin enhancer 2 (Psenen) and presenilin 1, components of the gamma-secretase com …