Search Page
Save citations to file
Email citations
Send citations to clipboard
Add to Collections
Add to My Bibliography
Create a file for external citation management software
Your saved search
Your RSS Feed
Search Results
2 results
Filters applied: . Clear all
Page 1
Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia.
Cancer Cell. 2023 Jan 9;41(1):70-87.e14. doi: 10.1016/j.ccell.2022.10.002. Epub 2022 Nov 3.
Cancer Cell. 2023.
PMID: 36332625
Free article.
This "transcriptional numbness" lowers the probability of cell death at early stages, increasing the chance of long-term adaptation at the population level. Our findings provide a mechanistic explanation for the widespread selection of subclonal epigenetic-related mutation …
This "transcriptional numbness" lowers the probability of cell death at early stages, increasing the chance of long-term adaptation a …
The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity.
Torres CM, Biran A, Burney MJ, Patel H, Henser-Brownhill T, Cohen AS, Li Y, Ben-Hamo R, Nye E, Spencer-Dene B, Chakravarty P, Efroni S, Matthews N, Misteli T, Meshorer E, Scaffidi P.
Torres CM, et al. Among authors: scaffidi p.
Science. 2016 Sep 30;353(6307):aaf1644. doi: 10.1126/science.aaf1644.
Science. 2016.
PMID: 27708074
Free PMC article.
Here, we show that dynamic epigenetic states defined by the linker histone H1.0 determine which cells within a tumor can sustain the long-term cancer growth. Numerous cancer types exhibit high inter- and intratumor heterogeneity of H1.0, with H1.0 levels correlating with t …
Here, we show that dynamic epigenetic states defined by the linker histone H1.0 determine which cells within a tumor can sustain the long- …
Item in Clipboard
Cite
Cite