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Lentiviral in situ targeting of stem cells in unperturbed intestinal epithelium.
Garside GB, Sandoval M, Beronja S, Rudolph KL. Garside GB, et al. Among authors: rudolph kl. BMC Biol. 2023 Jan 11;21(1):6. doi: 10.1186/s12915-022-01466-1. BMC Biol. 2023. PMID: 36627630 Free PMC article.
BACKGROUND: Methods for the long-term in situ transduction of the unperturbed murine intestinal epithelium have not been developed in past research. ...Postnatal analysis of young adult mice indicates that single transduced cells at E8.0 gave rise to crypt fields that were …
BACKGROUND: Methods for the long-term in situ transduction of the unperturbed murine intestinal epithelium have not been developed in …
Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction.
Gebert N, Cheng CW, Kirkpatrick JM, Di Fraia D, Yun J, Schädel P, Pace S, Garside GB, Werz O, Rudolph KL, Jasper H, Yilmaz ÖH, Ori A. Gebert N, et al. Among authors: rudolph kl. Cell Rep. 2020 Apr 28;31(4):107565. doi: 10.1016/j.celrep.2020.107565. Cell Rep. 2020. PMID: 32348758 Free PMC article.
We find that aging alters epithelial immunity, metabolism, and cell proliferation and is accompanied by region-dependent skewing in the cellular composition of the epithelium. Of note, short-term dietary restriction followed by refeeding partially restores the epithelium b …
We find that aging alters epithelial immunity, metabolism, and cell proliferation and is accompanied by region-dependent skewing in the cell …
Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging.
Tang D, Tao S, Chen Z, Koliesnik IO, Calmes PG, Hoerr V, Han B, Gebert N, Zörnig M, Löffler B, Morita Y, Rudolph KL. Tang D, et al. Among authors: rudolph kl. J Exp Med. 2016 Apr 4;213(4):535-53. doi: 10.1084/jem.20151100. Epub 2016 Mar 7. J Exp Med. 2016. PMID: 26951333 Free PMC article.
Together, these findings delineate positive and negative effects of long-term DR on HSC functionality involving distinct stress and growth signaling pathways....
Together, these findings delineate positive and negative effects of long-term DR on HSC functionality involving distinct stress and g …
Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.
Yamamoto R, Morita Y, Ooehara J, Hamanaka S, Onodera M, Rudolph KL, Ema H, Nakauchi H. Yamamoto R, et al. Among authors: rudolph kl. Cell. 2013 Aug 29;154(5):1112-1126. doi: 10.1016/j.cell.2013.08.007. Cell. 2013. PMID: 23993099 Free article.
Using a single-cell transplantation system and marker mice, we unexpectedly found myeloid-restricted progenitors with long-term repopulating activity (MyRPs), which are lineage-committed to megakaryocytes, megakaryocyte-erythroid cells, or common myeloid cells (MkRPs, MERP …
Using a single-cell transplantation system and marker mice, we unexpectedly found myeloid-restricted progenitors with long-term repop …
Functionality, growth and accelerated aging of tissue engineered living autologous vascular grafts.
Kelm JM, Emmert MY, Zürcher A, Schmidt D, Begus Nahrmann Y, Rudolph KL, Weber B, Brokopp CE, Frauenfelder T, Leschka S, Odermatt B, Jenni R, Falk V, Zünd G, Hoerstrup SP. Kelm JM, et al. Among authors: rudolph kl. Biomaterials. 2012 Nov;33(33):8277-85. doi: 10.1016/j.biomaterials.2012.07.049. Epub 2012 Aug 18. Biomaterials. 2012. PMID: 22906604
Here, the impact of biological cell-age and tissue-remodeling capacity of TEVGs in relation to their clinical long-term functionality are investigated. TEVGs were implanted as pulmonary-artery (PA) replacements in juvenile sheep and followed for up to 240 weeks (4.5years). …
Here, the impact of biological cell-age and tissue-remodeling capacity of TEVGs in relation to their clinical long-term functionality …
Telomere shortening reduces Alzheimer's disease amyloid pathology in mice.
Rolyan H, Scheffold A, Heinrich A, Begus-Nahrmann Y, Langkopf BH, Hölter SM, Vogt-Weisenhorn DM, Liss B, Wurst W, Lie DC, Thal DR, Biber K, Rudolph KL. Rolyan H, et al. Among authors: rudolph kl. Brain. 2011 Jul;134(Pt 7):2044-56. doi: 10.1093/brain/awr133. Epub 2011 Jun 14. Brain. 2011. PMID: 21672962
The study shows that aged telomerase knockout mice with short telomeres (G3Terc-/-) exhibit reduced dentate gyrus neurogenesis and loss of neurons in hippocampus and frontal cortex, associated with short-term memory deficit in comparison to mice with long telomere reserves …
The study shows that aged telomerase knockout mice with short telomeres (G3Terc-/-) exhibit reduced dentate gyrus neurogenesis and loss of n …
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TB, von Zglinicki T. Passos JF, et al. Among authors: rudolph kl. Mol Syst Biol. 2010;6:347. doi: 10.1038/msb.2010.5. Epub 2010 Feb 16. Mol Syst Biol. 2010. PMID: 20160708 Free PMC article.
Combining in-silico interactome analysis and functional target gene inhibition, stochastic modelling and live cell microscopy, we show here that there exists a dynamic feedback loop that is triggered by a DNA damage response (DDR) and, which after a delay of several days, locks t …
Combining in-silico interactome analysis and functional target gene inhibition, stochastic modelling and live cell microscopy, we show here …
Establishment of immortalized multipotent hematopoietic progenitor cell lines by retroviral-mediated gene transfer of beta-catenin.
Templin C, Kotlarz D, Rathinam C, Rudolph C, Schätzlein S, Ramireddy K, Rudolph KL, Schlegelberger B, Klein C, Drexler H. Templin C, et al. Among authors: rudolph kl. Exp Hematol. 2008 Feb;36(2):204-15. doi: 10.1016/j.exphem.2007.10.005. Exp Hematol. 2008. PMID: 18206728 Free article.
RESULTS: Retroviral-mediated overexpression of human beta-catenin in lin(-)- and lin(-)Sca-1+c-kit+ hematopoietic cells led to generation of novel, murine interleukin-3-, and stem cell factor-dependent hematopoietic multipotent progenitor cell lines (DK1mix and DK2mix) with stabl …
RESULTS: Retroviral-mediated overexpression of human beta-catenin in lin(-)- and lin(-)Sca-1+c-kit+ hematopoietic cells led to generation of …
Telomere dysfunction alters the chemotherapeutic profile of transformed cells.
Lee KH, Rudolph KL, Ju YJ, Greenberg RA, Cannizzaro L, Chin L, Weiler SR, DePinho RA. Lee KH, et al. Among authors: rudolph kl. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3381-6. doi: 10.1073/pnas.051629198. Proc Natl Acad Sci U S A. 2001. PMID: 11248087 Free PMC article.
Telomerase inhibition has been touted as a novel cancer-selective therapeutic goal based on the observation of high telomerase levels in most cancers and the importance of telomere maintenance in long-term cellular growth and survival. Here, the impact of telomere dysfunct …
Telomerase inhibition has been touted as a novel cancer-selective therapeutic goal based on the observation of high telomerase levels in mos …