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Mutation rates and adaptive variation among the clinically dominant clusters of Mycobacterium abscessus.
Commins N, Sullivan MR, McGowen K, Koch EM, Rubin EJ, Farhat M. Commins N, et al. Among authors: rubin ej. Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2302033120. doi: 10.1073/pnas.2302033120. Epub 2023 May 22. Proc Natl Acad Sci U S A. 2023. PMID: 37216535 Free PMC article.
We implement a subsampling approach in combination with coalescent analysis to estimate the molecular clock rate along the long internal branches of the tree, indicating a faster long-term molecular clock rate compared to branches within phylogenetic clusters. ...
We implement a subsampling approach in combination with coalescent analysis to estimate the molecular clock rate along the long internal bra …
Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing.
Zhang YJ, Reddy MC, Ioerger TR, Rothchild AC, Dartois V, Schuster BM, Trauner A, Wallis D, Galaviz S, Huttenhower C, Sacchettini JC, Behar SM, Rubin EJ. Zhang YJ, et al. Among authors: rubin ej. Cell. 2013 Dec 5;155(6):1296-308. doi: 10.1016/j.cell.2013.10.045. Cell. 2013. PMID: 24315099 Free PMC article.
Here, we present a genome-scale study of Mycobacterium tuberculosis (Mtb) that uncovers the bacterial determinants of surviving host immunity, sets of genes we term "counteractomes." Through this analysis, we found that CD4 T cells attempt to contain Mtb growth by starving …
Here, we present a genome-scale study of Mycobacterium tuberculosis (Mtb) that uncovers the bacterial determinants of surviving host immunit …
Letting sleeping dos lie: does dormancy play a role in tuberculosis?
Chao MC, Rubin EJ. Chao MC, et al. Among authors: rubin ej. Annu Rev Microbiol. 2010;64:293-311. doi: 10.1146/annurev.micro.112408.134043. Annu Rev Microbiol. 2010. PMID: 20825351 Review.
Latency and antibiotic tolerance are commonly taken as a proxy for dormancy, a stable nonreplicative state. However, latency is a clinical term that is solely defined by a lack of disease indicators. The actual state of the bacterium in human latency is not well understood …
Latency and antibiotic tolerance are commonly taken as a proxy for dormancy, a stable nonreplicative state. However, latency is a clinical …