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Page 1
Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury: a multicentre, randomised, double-blind, placebo-controlled, assessor-masked superiority trial.
Dahyot-Fizelier C, Lasocki S, Kerforne T, Perrigault PF, Geeraerts T, Asehnoune K, Cinotti R, Launey Y, Cottenceau V, Laffon M, Gaillard T, Boisson M, Aleyrat C, Frasca D, Mimoz O; PROPHY-VAP Study Group and the ATLANREA Study Group. Dahyot-Fizelier C, et al. Lancet Respir Med. 2024 May;12(5):375-385. doi: 10.1016/S2213-2600(23)00471-X. Epub 2024 Jan 20. Lancet Respir Med. 2024. PMID: 38262428 Clinical Trial.
BACKGROUND: Patients with acute brain injury are at high risk of ventilator-associated pneumonia (VAP). The benefit of short-term antibiotic prophylaxis remains debated. We aimed to establish the effect of an early, single dose of the antibiotic ceftriaxone on the incidenc …
BACKGROUND: Patients with acute brain injury are at high risk of ventilator-associated pneumonia (VAP). The benefit of short-term ant …
Long-Term Outcome of Severe Metabolic Acidemia in ICU Patients, a BICAR-ICU Trial Post Hoc Analysis.
Bendiab E, Garnier F, Soler M, Fosset M, Jaber S, Molinari N, Jung B; BICAR-ICU Investigators. Bendiab E, et al. Crit Care Med. 2023 Jan 1;51(1):e1-e12. doi: 10.1097/CCM.0000000000005706. Epub 2022 Nov 8. Crit Care Med. 2023. PMID: 36351174 Clinical Trial.
OBJECTIVES: Long-term prognosis of ICU survivors is a major issue. Severe acidemia upon ICU admission is associated with very high short-term mortality. Since the long-term prognosis of these patients is unknown, we aimed to determine the long-term hea …
OBJECTIVES: Long-term prognosis of ICU survivors is a major issue. Severe acidemia upon ICU admission is associated with very high sh …
Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis.
Roquilly A, Jacqueline C, Davieau M, Mollé A, Sadek A, Fourgeux C, Rooze P, Broquet A, Misme-Aucouturier B, Chaumette T, Vourc'h M, Cinotti R, Marec N, Gauttier V, McWilliam HEG, Altare F, Poschmann J, Villadangos JA, Asehnoune K. Roquilly A, et al. Nat Immunol. 2020 Jun;21(6):636-648. doi: 10.1038/s41590-020-0673-x. Epub 2020 May 18. Nat Immunol. 2020. PMID: 32424365
Corticosteroids administration to improve outcome in high-risk surgical patients.
Asehnoune K, Vourc'h M, Roquilly A. Asehnoune K, et al. Among authors: roquilly a. Curr Opin Crit Care. 2018 Dec;24(6):575-580. doi: 10.1097/MCC.0000000000000553. Curr Opin Crit Care. 2018. PMID: 30247218 Review.
PURPOSE OF REVIEW: Postoperative complications are major healthcare problems and are associated with a reduced short-term and long-term survival. Major surgery is associated with a predictable and usually transient systemic inflammatory response (SIRS), depending on …
PURPOSE OF REVIEW: Postoperative complications are major healthcare problems and are associated with a reduced short-term and long- …
Alveolar Macrophages: Adaptation to Their Anatomic Niche during and after Inflammation.
Martin FP, Jacqueline C, Poschmann J, Roquilly A. Martin FP, et al. Among authors: roquilly a. Cells. 2021 Oct 12;10(10):2720. doi: 10.3390/cells10102720. Cells. 2021. PMID: 34685700 Free PMC article. Review.
In some cases, lung-trained immunity offers better defense capacities against autoimmune disorders and the long-term risk of infection. At the opposite, it can perpetuate a harmful process and lead to a pathological state, as is the case among critically ill patients who h …
In some cases, lung-trained immunity offers better defense capacities against autoimmune disorders and the long-term risk of infectio …
[Brain injury, immunity and infections].
Roquilly A, Lejus C, Asehnoune K. Roquilly A, et al. Ann Fr Anesth Reanim. 2012 Jun;31(6):e97-100. doi: 10.1016/j.annfar.2012.04.012. Epub 2012 Jun 7. Ann Fr Anesth Reanim. 2012. PMID: 22683165 Review. French.
Specialized units of care for ischemic stroke, taking into account the risk of infection related to the IS, have improved the prognosis until 18th month after the initial damage of the SNC. It is now well recognized that the improved long-term prognosis is related with the …
Specialized units of care for ischemic stroke, taking into account the risk of infection related to the IS, have improved the prognosis unti …
Anxiety and depression symptoms in relatives of moderate-to-severe traumatic brain injury survivors - A multicentre cohort.
Cinotti R, Chopin A, Moyer JD, Huet O, Lasocki S, Cohen B, Dahyot-Fizelier C, Chalard K, Seguin P, Martin FP, Lerebourg C, Guitteny M, Chenet A, Perrouin-Verbe B, Asehnoune K, Feuillet F, Sébille V, Roquilly A; Atlanréa Group and the Société Française d’Anesthésie-Réanimation–SFAR Research Network. Cinotti R, et al. Among authors: roquilly a. Anaesth Crit Care Pain Med. 2023 Oct;42(5):101232. doi: 10.1016/j.accpm.2023.101232. Epub 2023 Apr 11. Anaesth Crit Care Pain Med. 2023. PMID: 37054915 Clinical Trial.
Anxiety and depression were inversely correlated with the patient's mental health status at 6 months. CONCLUSIONS: Long-term follow-up must provide psychological care to relatives after TBI....
Anxiety and depression were inversely correlated with the patient's mental health status at 6 months. CONCLUSIONS: Long-term follow-u …
Characteristics and Prognosis Factors of Pneumocystis jirovecii Pneumonia According to Underlying Disease: A Retrospective Multicenter Study.
Lécuyer R, Issa N, Camou F, Lavergne RA, Gabriel F, Morio F, Canet E, Raffi F, Boutoille D, Cady A, Gousseff M, Crabol Y, Néel A, Tessoulin B, Gaborit B; PRONOCYSTIS Study Group. Lécuyer R, et al. Chest. 2024 Jan 11:S0012-3692(24)00022-9. doi: 10.1016/j.chest.2024.01.015. Online ahead of print. Chest. 2024. PMID: 38215935 Free article.

In multivariate analysis, among the HIV-negative population, solid tumor underlying disease (OR, 5.47; 95% CI, 2.16-14.1; P < .001), IMIDs (OR, 2.19; 95% CI, 1.05-4.60; P = .037), long-term corticosteroid exposure (OR, 2.07; 95% CI, 1.03-4.31; P = .045), cysts in sputum

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In multivariate analysis, among the HIV-negative population, solid tumor underlying disease (OR, 5.47; 95% CI, 2.16-14.1; P < .001), IMID

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Tracheostomy and long-term mortality in ICU patients undergoing prolonged mechanical ventilation.
Cinotti R, Voicu S, Jaber S, Chousterman B, Paugam-Burtz C, Oueslati H, Damoisel C, Caillard A, Roquilly A, Feuillet F, Mebazaa A, Gayat E; FROG-ICU investigators. Cinotti R, et al. Among authors: roquilly a. PLoS One. 2019 Oct 2;14(10):e0220399. doi: 10.1371/journal.pone.0220399. eCollection 2019. PLoS One. 2019. PMID: 31577804 Free PMC article. Clinical Trial.
INTRODUCTION: In critically ill patients undergoing prolonged mechanical ventilation (MV), the difference in long-term outcomes between patients with or without tracheostomy remains unexplored. ...
INTRODUCTION: In critically ill patients undergoing prolonged mechanical ventilation (MV), the difference in long-term outcomes betwe …
19 results