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Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure.
Bishawi M, Lee FH, Abraham DM, Glass C, Blocker SJ, Cox DJ, Brown ZD, Rockman HA, Mao L, Slaba TC, Dewhirst MW, Truskey GA, Bowles DE. Bishawi M, et al. Among authors: rockman ha. iScience. 2022 Mar 16;25(4):104086. doi: 10.1016/j.isci.2022.104086. eCollection 2022 Apr 15. iScience. 2022. PMID: 35378858 Free PMC article.
The complex and inaccessible space radiation environment poses an unresolved risk to astronaut cardiovascular health during long-term space exploration missions. To model this risk, healthy male c57BL/6 mice aged six months (corresponding to an astronaut of 34 years) were …
The complex and inaccessible space radiation environment poses an unresolved risk to astronaut cardiovascular health during long-term …
Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction.
Yoo B, Lemaire A, Mangmool S, Wolf MJ, Curcio A, Mao L, Rockman HA. Yoo B, et al. Among authors: rockman ha. Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1377-86. doi: 10.1152/ajpheart.00504.2009. Epub 2009 Jul 24. Am J Physiol Heart Circ Physiol. 2009. PMID: 19633206 Free PMC article.
Cardiac inotropy, chronotropy, and CaMKII activity following short-term isoproterenol stimulation were significantly attenuated in beta(1)ARKO and DKO compared with either the beta(2)ARKO or wild-type (WT) mice, indicating that beta(1)ARs are required for catecholamine-ind …
Cardiac inotropy, chronotropy, and CaMKII activity following short-term isoproterenol stimulation were significantly attenuated in be …
Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence.
Mohler PJ, Healy JA, Xue H, Puca AA, Kline CF, Allingham RR, Kranias EG, Rockman HA, Bennett V. Mohler PJ, et al. Among authors: rockman ha. PLoS One. 2007 Oct 17;2(10):e1051. doi: 10.1371/journal.pone.0001051. PLoS One. 2007. PMID: 17940615 Free PMC article.
Together these findings suggest a constellation of traits that we term "ankyrin-B syndrome", which may contribute to both aging-related disorders and enhanced cardiac function....
Together these findings suggest a constellation of traits that we term "ankyrin-B syndrome", which may contribute to both aging-relat …