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SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3.
Tripathi U, Nchioua R, Prata LGPL, Zhu Y, Gerdes EOW, Giorgadze N, Pirtskhalava T, Parker E, Xue A, Espindola-Netto JM, Stenger S, Robbins PD, Niedernhofer LJ, Dickinson SL, Allison DB, Kirchhoff F, Sparrer KMJ, Tchkonia T, Kirkland JL. Tripathi U, et al. Among authors: robbins pd. Aging (Albany NY). 2021 Sep 16;13(18):21838-21854. doi: 10.18632/aging.203560. Epub 2021 Sep 16. Aging (Albany NY). 2021. PMID: 34531331 Free PMC article.
Our results suggest that induction of cellular senescence and SASP amplification through TLR-3 contribute to SARS-CoV-2 morbidity, indicating that clinical trials of senolytics and/or SASP/TLR-3 inhibitors for alleviating acute and long-term SARS-CoV-2 sequelae are warrant …
Our results suggest that induction of cellular senescence and SASP amplification through TLR-3 contribute to SARS-CoV-2 morbidity, indicatin …
Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era.
Verdoorn BP, Evans TK, Hanson GJ, Zhu Y, Langhi Prata LGP, Pignolo RJ, Atkinson EJ, Wissler-Gerdes EO, Kuchel GA, Mannick JB, Kritchevsky SB, Khosla S, Rizza SA, Walston JD, Musi N, Lipsitz LA, Kiel DP, Yung R, LeBrasseur NK, Singh RJ, McCarthy T, Puskarich MA, Niedernhofer LJ, Robbins PD, Sorenson M, Tchkonia T, Kirkland JL. Verdoorn BP, et al. Among authors: robbins pd. J Am Geriatr Soc. 2021 Nov;69(11):3023-3033. doi: 10.1111/jgs.17416. Epub 2021 Aug 20. J Am Geriatr Soc. 2021. PMID: 34375437 Free PMC article.
We consider logistic challenges of conducting trials in long-term care settings in the SARS-CoV-2 era, including restricted access, consent procedures, methods for obtaining biospecimens and clinical data, staffing, investigational product administration issues, and potent …
We consider logistic challenges of conducting trials in long-term care settings in the SARS-CoV-2 era, including restricted access, c …
Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice.
Saccon TD, Nagpal R, Yadav H, Cavalcante MB, Nunes ADC, Schneider A, Gesing A, Hughes B, Yousefzadeh M, Tchkonia T, Kirkland JL, Niedernhofer LJ, Robbins PD, Masternak MM. Saccon TD, et al. Among authors: robbins pd. J Gerontol A Biol Sci Med Sci. 2021 Oct 13;76(11):1895-1905. doi: 10.1093/gerona/glab002. J Gerontol A Biol Sci Med Sci. 2021. PMID: 33406219 Free PMC article.
The senolytic drug combination, Dasatinib plus Quercetin (D+Q), is known to reduce senescent cell abundance in aged mice. However, the effects of long-term D+Q treatment on intestinal senescent cell and inflammatory burden and microbiome composition in aged mice remain unk …
The senolytic drug combination, Dasatinib plus Quercetin (D+Q), is known to reduce senescent cell abundance in aged mice. However, the effec …
Development of an IGF1R longevity variant mouse line using CRISPR/Cas9 genome editing.
Dou Y, Darvas M, Sharma K, Mathieu J, Morton J, Tan H, Soto-Palma C, Angelini LA, McGowan SJ, Niedernhofer LJ, Suh Y, Robbins PD, Barzilai N, Ladiges WC. Dou Y, et al. Among authors: robbins pd. Trends Biomed Res. 2020 Dec;3(1):121. doi: 10.15761/jtbr.1000121. Epub 2020 Oct 8. Trends Biomed Res. 2020. PMID: 37113577 Free PMC article.
In addition, depletion of IGF1R signaling specifically in skeletal muscle of progeroid Ercc1 (-/delta) mice resulted in extended health span and median lifespan providing the rationale for long term lifespan studies in Igf1r hR407H variant mice. This mouse line will be a v …
In addition, depletion of IGF1R signaling specifically in skeletal muscle of progeroid Ercc1 (-/delta) mice resulted in extended health span …
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.
Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borràs FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MÁ, Brigstock DR, Brisson A, Broekman ML, Bromberg JF, Bryl-Górecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzás EI, Byrd JB, Camussi G, Carter DR, Caruso S, Chamley LW, Chang YT, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP, Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FA, Coyle B, Crescitelli R, Criado MF, D'Souza-Schorey C, Das S, Datta Chaudhuri A, de Candia P, De Santana EF, De Wever O, Del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TA, Duarte FV, Duncan HM, Eichenberger RM, Ekström K, El Andaloussi S, Elie-Caille C, Erdbrügger U, Falcón-Pérez JM, Fatima F, Fish JE, Flores-Bellver M, Försönit… See abstract for full author list ➔ Théry C, et al. Among authors: robbins pd. J Extracell Vesicles. 2018 Nov 23;7(1):1535750. doi: 10.1080/20013078.2018.1535750. eCollection 2018. J Extracell Vesicles. 2018. PMID: 30637094 Free PMC article.
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, mic …
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of ex …
The Clinical Potential of Senolytic Drugs.
Kirkland JL, Tchkonia T, Zhu Y, Niedernhofer LJ, Robbins PD. Kirkland JL, et al. Among authors: robbins pd. J Am Geriatr Soc. 2017 Oct;65(10):2297-2301. doi: 10.1111/jgs.14969. Epub 2017 Sep 4. J Am Geriatr Soc. 2017. PMID: 28869295 Free PMC article.
To do so, new clinical trial paradigms for testing senolytics and other agents that target fundamental aging mechanisms are being developed, because use of long-term endpoints such as lifespan or healthspan is not feasible. These strategies include testing effects on multi …
To do so, new clinical trial paradigms for testing senolytics and other agents that target fundamental aging mechanisms are being developed, …
Arthritis gene therapy and its tortuous path into the clinic.
Evans CH, Ghivizzani SC, Robbins PD. Evans CH, et al. Among authors: robbins pd. Transl Res. 2013 Apr;161(4):205-16. doi: 10.1016/j.trsl.2013.01.002. Epub 2013 Jan 29. Transl Res. 2013. PMID: 23369825 Free PMC article. Review.
There is an abundance of preclinical data confirming that genes can be efficiently transferred to tissues within joints by intra-articular injection using a variety of different vectors in conjunction with ex vivo and in vivo strategies. Using the appropriate gene transfer techno …
There is an abundance of preclinical data confirming that genes can be efficiently transferred to tissues within joints by intra-articular i …
Bioplasty for vertebral fractures: preliminary results of a pre-clinical study on goats using autologous modified skin fibroblasts.
Pola E, Nasto LA, Tampieri A, Lattanzi W, Di Giacomo G, Colangelo D, Ciriello V, Pagano E, Spinelli S, Robbins PD, Logroscino G. Pola E, et al. Among authors: robbins pd. Int J Immunopathol Pharmacol. 2011 Jan-Mar;24(1 Suppl 2):139-42. doi: 10.1177/03946320110241S226. Int J Immunopathol Pharmacol. 2011. PMID: 21669153 Free PMC article.
The debate is still ongoing about the long term effects of the mininvasive vertebral augmentation techniques and their usefulness in treating more complex cases where a bone inducing effect more than a merely bone substitution would be suitable, such as the vertebral fract …
The debate is still ongoing about the long term effects of the mininvasive vertebral augmentation techniques and their usefulness in …
DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes.
Riedel MJ, Gaddy DF, Asadi A, Robbins PD, Kieffer TJ. Riedel MJ, et al. Among authors: robbins pd. Gene Ther. 2010 Feb;17(2):171-80. doi: 10.1038/gt.2009.143. Epub 2009 Oct 29. Gene Ther. 2010. PMID: 19865180
It has recently been demonstrated that self-complimentary, double-stranded, adeno-associated virus serotype-8 (DsAAV8) can efficiently transduce pancreatic beta-cells in vivo, resulting in long-term transgene expression. In this study, we engineered a DsAAV8 vector contain …
It has recently been demonstrated that self-complimentary, double-stranded, adeno-associated virus serotype-8 (DsAAV8) can efficiently trans …
Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis.
Wehling P, Reinecke J, Baltzer AW, Granrath M, Schulitz KP, Schultz C, Krauspe R, Whiteside TW, Elder E, Ghivizzani SC, Robbins PD, Evans CH. Wehling P, et al. Among authors: robbins pd. Hum Gene Ther. 2009 Feb;20(2):97-101. doi: 10.1089/hum.2008.075. Hum Gene Ther. 2009. PMID: 18986219 Free PMC article. Clinical Trial.
Thus, gene transfer to human, rheumatoid joints can be accomplished safely to produce clinical benefit, at least in the short term. Using this ex vivo procedure, the transgene persisted within the joint for at least 1 month. ...
Thus, gene transfer to human, rheumatoid joints can be accomplished safely to produce clinical benefit, at least in the short term. U …
37 results