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Page 1
Self-organization of plasticity and specialization in a primitively social insect.
Patalano S, Alsina A, Gregorio-Rodríguez C, Bachman M, Dreier S, Hernando-Herraez I, Nana P, Balasubramanian S, Sumner S, Reik W, Rulands S. Patalano S, et al. Among authors: reik w. Cell Syst. 2022 Sep 21;13(9):768-779.e4. doi: 10.1016/j.cels.2022.08.002. Epub 2022 Aug 30. Cell Syst. 2022. PMID: 36044898 Free PMC article.
This allows Polistes to be stable against intrinsic perturbations of molecular states while reacting plastically to extrinsic cues affecting the whole society. Long-term stability of the social structure is reinforced by dynamic DNA methylation. ...
This allows Polistes to be stable against intrinsic perturbations of molecular states while reacting plastically to extrinsic cues affecting …
Single-cell multi-omics of human preimplantation embryos shows susceptibility to glucocorticoids.
Zhao C, Biondic S, Vandal K, Björklund ÅK, Hagemann-Jensen M, Sommer TM, Canizo J, Clark S, Raymond P, Zenklusen DR, Rivron N, Reik W, Petropoulos S. Zhao C, et al. Among authors: reik w. Genome Res. 2022 Aug 10;32(9):1627-41. doi: 10.1101/gr.276665.122. Online ahead of print. Genome Res. 2022. PMID: 35948369 Free PMC article.
This study suggests that exposures to exogenous compounds during preimplantation may unintentionally reprogram the human embryo, possibly leading to suboptimal development and longer-term health outcomes....
This study suggests that exposures to exogenous compounds during preimplantation may unintentionally reprogram the human embryo, possibly le …
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Takashima Y, Guo G, Loos R, Nichols J, Ficz G, Krueger F, Oxley D, Santos F, Clarke J, Mansfield W, Reik W, Bertone P, Smith A. Takashima Y, et al. Among authors: reik w. Cell. 2014 Sep 11;158(6):1254-1269. doi: 10.1016/j.cell.2014.08.029. Cell. 2014. PMID: 25215486 Free PMC article.
Current human pluripotent stem cells lack the transcription factor circuitry that governs the ground state of mouse embryonic stem cells (ESC). Here, we report that short-term expression of two components, NANOG and KLF2, is sufficient to ignite other elements of the netwo …
Current human pluripotent stem cells lack the transcription factor circuitry that governs the ground state of mouse embryonic stem cells (ES …
Etoposide induces nuclear re-localisation of AID.
Lambert LJ, Walker S, Feltham J, Lee HJ, Reik W, Houseley J. Lambert LJ, et al. Among authors: reik w. PLoS One. 2013 Dec 4;8(12):e82110. doi: 10.1371/journal.pone.0082110. eCollection 2013. PLoS One. 2013. PMID: 24324754 Free PMC article.
We conclude that DSB formation initiates a slow-acting pathway which allows stable long-term nuclear localisation of AID, and that such a pathway may enable AID-induced DNA demethylation during epigenetic reprogramming....
We conclude that DSB formation initiates a slow-acting pathway which allows stable long-term nuclear localisation of AID, and that su …
The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells.
Seisenberger S, Andrews S, Krueger F, Arand J, Walter J, Santos F, Popp C, Thienpont B, Dean W, Reik W. Seisenberger S, et al. Among authors: reik w. Mol Cell. 2012 Dec 28;48(6):849-62. doi: 10.1016/j.molcel.2012.11.001. Epub 2012 Dec 6. Mol Cell. 2012. PMID: 23219530 Free PMC article.
Global loss of methylation takes place during PGC expansion and migration with evidence for passive demethylation, but sequences that carry long-term epigenetic memory (imprints, CpG islands on the X chromosome, germline-specific genes) only become demethylated upon entry …
Global loss of methylation takes place during PGC expansion and migration with evidence for passive demethylation, but sequences that carry …
Raised late pregnancy glucose concentrations in mice carrying pups with targeted disruption of H19delta13.
Petry CJ, Evans ML, Wingate DL, Ong KK, Reik W, Constância M, Dunger DB. Petry CJ, et al. Among authors: reik w. Diabetes. 2010 Jan;59(1):282-6. doi: 10.2337/db09-0757. Epub 2009 Sep 30. Diabetes. 2010. PMID: 19794064 Free PMC article.
However, at day 16 mothers carrying H19(Delta13)-null pups had a significantly higher area under the glucose tolerance test curves than controls (1,845 +/- 378 vs. 1,386 +/- 107 mmol * min * l(-1) [P = 0.01]) in association with increasing pregnancy-related insulin resistance. Al …
However, at day 16 mothers carrying H19(Delta13)-null pups had a significantly higher area under the glucose tolerance test curves than cont …
Stability and flexibility of epigenetic gene regulation in mammalian development.
Reik W. Reik W. Nature. 2007 May 24;447(7143):425-32. doi: 10.1038/nature05918. Nature. 2007. PMID: 17522676 Review.
Pluripotent stem cells express genes that encode a set of core transcription factors, while genes that are required later in development are repressed by histone marks, which confer short-term, and therefore flexible, epigenetic silencing. By contrast, the methylation of D …
Pluripotent stem cells express genes that encode a set of core transcription factors, while genes that are required later in development are …
Regulation of placental efficiency for nutrient transport by imprinted genes.
Angiolini E, Fowden A, Coan P, Sandovici I, Smith P, Dean W, Burton G, Tycko B, Reik W, Sibley C, Constância M. Angiolini E, et al. Among authors: reik w. Placenta. 2006 Apr;27 Suppl A:S98-102. doi: 10.1016/j.placenta.2005.12.008. Epub 2006 Feb 28. Placenta. 2006. PMID: 16503350 Review.
Intrauterine growth and development can impact upon the long-term health of an individual. The fetus is dependent upon the placenta for its supply of nutrients and oxygen from the mother. ...
Intrauterine growth and development can impact upon the long-term health of an individual. The fetus is dependent upon the placenta f …
Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems.
Constância M, Angiolini E, Sandovici I, Smith P, Smith R, Kelsey G, Dean W, Ferguson-Smith A, Sibley CP, Reik W, Fowden A. Constância M, et al. Among authors: reik w. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19219-24. doi: 10.1073/pnas.0504468103. Epub 2005 Dec 19. Proc Natl Acad Sci U S A. 2005. PMID: 16365304 Free PMC article.
An altered balance between supply and demand can lead to deviations from this trajectory with long-term consequences for health. We have previously shown that in a knockout lacking the imprinted placental-specific Igf2 transcript (P0), growth of the placenta is compromised …
An altered balance between supply and demand can lead to deviations from this trajectory with long-term consequences for health. We h …
Generation of monoparental embryos for investigation into genomic imprinting.
Dean WL, Kelsey G, Reik W. Dean WL, et al. Among authors: reik w. Methods Mol Biol. 2001;181:1-19. doi: 10.1385/1-59259-211-2:1. Methods Mol Biol. 2001. PMID: 12843438
The seminal work of McGrath and Solter (1) and independently of Surani et al. (2) in 1984 established the fundamental principle of nuclear nonequivalency; that is, chromosomes of both paternal and maternal origin are required for development to term in mammals. This was ac …
The seminal work of McGrath and Solter (1) and independently of Surani et al. (2) in 1984 established the fundamental principle of nuclear n …
15 results