Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Takashima Y, Guo G, Loos R, Nichols J, Ficz G, Krueger F, Oxley D, Santos F, Clarke J, Mansfield W, Reik W, Bertone P, Smith A.
Takashima Y, et al. Among authors: reik w.
Cell. 2014 Sep 11;158(6):1254-1269. doi: 10.1016/j.cell.2014.08.029.
Cell. 2014.
PMID: 25215486
Free PMC article.
Current human pluripotent stem cells lack the transcription factor circuitry that governs the ground state of mouse embryonic stem cells (ESC). Here, we report that short-term expression of two components, NANOG and KLF2, is sufficient to ignite other elements of the netwo …
Current human pluripotent stem cells lack the transcription factor circuitry that governs the ground state of mouse embryonic stem cells (ES …