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Impact of transcranial magnetic stimulation on motor function in children with acquired brain injury: a scoping review protocol.
Rathinam C, Mohan V, Bill P, Yates D, Gupta R, Peirson J. Rathinam C, et al. BMJ Paediatr Open. 2023 May;7(1):e001885. doi: 10.1136/bmjpo-2023-001885. BMJ Paediatr Open. 2023. PMID: 37130655 Free PMC article.
BACKGROUND: Children with severe acquired brain injury (ABI) require early and effective neurorehabilitation provision to promote a good long-term functional outcome. Transcranial magnetic stimulation (TMS) has been used to improve motor skills for children with cerebral p …
BACKGROUND: Children with severe acquired brain injury (ABI) require early and effective neurorehabilitation provision to promote a good lon …
Parents' experience of children with acquired brain injury undergoing neuro-rehabilitation: thematic synthesis protocol.
Fernandes M, Rathinam C, Topping AE. Fernandes M, et al. Among authors: rathinam c. BMJ Open. 2023 Apr 19;13(4):e066254. doi: 10.1136/bmjopen-2022-066254. BMJ Open. 2023. PMID: 37076161 Free PMC article.
INTRODUCTION: Children with moderate to severe acquired brain injury frequently require a period of demanding medical and rehabilitative care to optimise their long-term capabilities and quality of life. Usually, the initial acute care is provided in tertiary centres and c …
INTRODUCTION: Children with moderate to severe acquired brain injury frequently require a period of demanding medical and rehabilitative car …
A20 deficiency in multipotent progenitors perturbs quiescence of hematopoietic stem cells.
Nakagawa MM, Davis H, Rathinam CV. Nakagawa MM, et al. Among authors: rathinam cv. Stem Cell Res. 2018 Dec;33:199-205. doi: 10.1016/j.scr.2018.10.020. Epub 2018 Oct 31. Stem Cell Res. 2018. PMID: 30445411 Free PMC article.
Interestingly, A20 deficiency in MPPs caused loss of HSC quiescence and compromised long-term hematopoietic reconstitution. Mechanistic studies identified that A20 deficiency caused elevated levels of Interferon-gamma signaling and downregulation of p57 in HSCs. ...
Interestingly, A20 deficiency in MPPs caused loss of HSC quiescence and compromised long-term hematopoietic reconstitution. Mechanist …
FoxO1-dependent induction of acute myeloid leukemia by osteoblasts in mice.
Kode A, Mosialou I, Manavalan SJ, Rathinam CV, Friedman RA, Teruya-Feldstein J, Bhagat G, Berman E, Kousteni S. Kode A, et al. Among authors: rathinam cv. Leukemia. 2016 Jan;30(1):1-13. doi: 10.1038/leu.2015.161. Epub 2015 Jun 25. Leukemia. 2016. PMID: 26108693 Free PMC article.
At the molecular level, FoxO1 interacts with beta-catenin in osteoblasts to induce expression of the Notch ligand, Jagged-1. Subsequent activation of Notch signaling in long-term repopulating HSC progenitors induces the leukemogenic transformation of HSCs and ultimately le …
At the molecular level, FoxO1 interacts with beta-catenin in osteoblasts to induce expression of the Notch ligand, Jagged-1. Subsequent acti …
Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts.
Kode A, Manavalan JS, Mosialou I, Bhagat G, Rathinam CV, Luo N, Khiabanian H, Lee A, Murty VV, Friedman R, Brum A, Park D, Galili N, Mukherjee S, Teruya-Feldstein J, Raza A, Rabadan R, Berman E, Kousteni S. Kode A, et al. Among authors: rathinam cv. Nature. 2014 Feb 13;506(7487):240-4. doi: 10.1038/nature12883. Epub 2014 Jan 15. Nature. 2014. PMID: 24429522 Free PMC article.
Cells of the osteoblast lineage affect the homing and the number of long-term repopulating haematopoietic stem cells, haematopoietic stem cell mobilization and lineage determination and B cell lymphopoiesis. ...
Cells of the osteoblast lineage affect the homing and the number of long-term repopulating haematopoietic stem cells, haematopoietic …
The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells.
Rathinam C, Matesic LE, Flavell RA. Rathinam C, et al. Nat Immunol. 2011 May;12(5):399-407. doi: 10.1038/ni.2021. Epub 2011 Apr 10. Nat Immunol. 2011. PMID: 21478879 Free PMC article.
Itch(-/-) mice had HSCs with enhanced frequency, competence and long-term repopulating activity. Itch-deficient HSCs showed accelerated proliferation rates and sustained progenitor properties, as well as more signaling by the transcription factor Notch1, due to more accumu …
Itch(-/-) mice had HSCs with enhanced frequency, competence and long-term repopulating activity. Itch-deficient HSCs showed accelerat …
The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells.
Rathinam C, Thien CB, Langdon WY, Gu H, Flavell RA. Rathinam C, et al. Genes Dev. 2008 Apr 15;22(8):992-7. doi: 10.1101/gad.1651408. Genes Dev. 2008. PMID: 18413713 Free PMC article.
HSCs of c-Cbl(-/-) mice exhibit augmented pool size, hyperproliferation, greater competence, and enhanced long-term repopulating capacity. Our mechanistic studies identified that c-Cbl(-/-) HSCs are hyperresponsive to thrombopoietin (TPO) and display elevated levels of STA …
HSCs of c-Cbl(-/-) mice exhibit augmented pool size, hyperproliferation, greater competence, and enhanced long-term repopulating capa …
Establishment of immortalized multipotent hematopoietic progenitor cell lines by retroviral-mediated gene transfer of beta-catenin.
Templin C, Kotlarz D, Rathinam C, Rudolph C, Schätzlein S, Ramireddy K, Rudolph KL, Schlegelberger B, Klein C, Drexler H. Templin C, et al. Among authors: rathinam c. Exp Hematol. 2008 Feb;36(2):204-15. doi: 10.1016/j.exphem.2007.10.005. Exp Hematol. 2008. PMID: 18206728 Free article.
RESULTS: Retroviral-mediated overexpression of human beta-catenin in lin(-)- and lin(-)Sca-1+c-kit+ hematopoietic cells led to generation of novel, murine interleukin-3-, and stem cell factor-dependent hematopoietic multipotent progenitor cell lines (DK1mix and DK2mix) with stabl …
RESULTS: Retroviral-mediated overexpression of human beta-catenin in lin(-)- and lin(-)Sca-1+c-kit+ hematopoietic cells led to generation of …