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Page 1
Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase.
Lange Y, Ory DS, Ye J, Lanier MH, Hsu FF, Steck TL. Lange Y, et al. J Biol Chem. 2008 Jan 18;283(3):1445-1455. doi: 10.1074/jbc.M706967200. Epub 2007 Nov 16. J Biol Chem. 2008. PMID: 18024962 Free article.
We have now examined the roles of sterol regulatory element-binding protein (SREBP)-dependent gene expression, side chain oxysterol biosynthesis, and cholesterol precursors in the short term regulation of ER cholesterol levels and HMGR activity. We found that SREBP-depende …
We have now examined the roles of sterol regulatory element-binding protein (SREBP)-dependent gene expression, side chain oxysterol biosynth …
Mechanism of highly active anti-retroviral therapy-induced hyperlipidemia in HIV-infected individuals.
Carpentier A, Patterson BW, Uffelman KD, Salit I, Lewis GF. Carpentier A, et al. Atherosclerosis. 2005 Jan;178(1):165-72. doi: 10.1016/j.atherosclerosis.2004.07.035. Atherosclerosis. 2005. PMID: 15585214
The use of highly active anti-retroviral therapy (HAART) is associated with long-term adverse metabolic events including lipodystrophy, dyslipidemia, and insulin resistance. ...
The use of highly active anti-retroviral therapy (HAART) is associated with long-term adverse metabolic events including lipodystroph …
Treatment with oxandrolone and the durability of effects in older men.
Schroeder ET, Zheng L, Yarasheski KE, Qian D, Stewart Y, Flores C, Martinez C, Terk M, Sattler FR. Schroeder ET, et al. J Appl Physiol (1985). 2004 Mar;96(3):1055-62. doi: 10.1152/japplphysiol.00808.2003. Epub 2003 Oct 24. J Appl Physiol (1985). 2004. PMID: 14578370 Free article. Clinical Trial.
However, the decreases in total and trunk fat were sustained (-1.5 +/- 1.8, P = 0.001 and -1.0 +/- 1.1 kg, P < 0.001, respectively). Thus oxandrolone induced short-term improvements in LBM, muscle area, and strength, while reducing whole body and trunk adiposity. ...

However, the decreases in total and trunk fat were sustained (-1.5 +/- 1.8, P = 0.001 and -1.0 +/- 1.1 kg, P < 0.001, respectively). Thus

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Gender differences in lipid and glucose kinetics during short-term fasting.
Mittendorfer B, Horowitz JF, Klein S. Mittendorfer B, et al. Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1333-9. doi: 10.1152/ajpendo.2001.281.6.E1333. Am J Physiol Endocrinol Metab. 2001. PMID: 11701450 Free article. Clinical Trial.
However, differences in body composition between males and females confound the interpretation of these studies, because increased adiposity itself alters the metabolic response to short-term fasting. We evaluated whole body lipid and glucose kinetics during basal (14-h fa …
However, differences in body composition between males and females confound the interpretation of these studies, because increased adiposity …
A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease.
Pennathur S, Wagner JD, Leeuwenburgh C, Litwak KN, Heinecke JW. Pennathur S, et al. J Clin Invest. 2001 Apr;107(7):853-60. doi: 10.1172/JCI11194. J Clin Invest. 2001. PMID: 11285304 Free PMC article.
Moreover, tissue levels of ortho-tyrosine and meta-tyrosine correlated strongly with serum levels of glycated hemoglobin, a measure of glycemic control. We conclude that short-term hyperglycemia in primates promotes oxidation of artery wall proteins by a species that resem …
Moreover, tissue levels of ortho-tyrosine and meta-tyrosine correlated strongly with serum levels of glycated hemoglobin, a measure of glyce …
Metabolic and clinical response to recombinant human insulin-like growth factor I in myotonic dystrophy--a clinical research center study.
Vlachopapadopoulou E, Zachwieja JJ, Gertner JM, Manzione D, Bier DM, Matthews DE, Slonim AE. Vlachopapadopoulou E, et al. J Clin Endocrinol Metab. 1995 Dec;80(12):3715-23. doi: 10.1210/jcem.80.12.8530624. J Clin Endocrinol Metab. 1995. PMID: 8530624 Clinical Trial.

An increase in manual muscle strength of 0.42 +/- 0.30 (P < 0.02) and in neuromuscular function of 17.5 +/- 11.7 (P < 0.02) occurred in the four patients who received a rhIGF-I dose greater than 70 micrograms/kg, whereas a more modest response occurred in the three patients

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An increase in manual muscle strength of 0.42 +/- 0.30 (P < 0.02) and in neuromuscular function of 17.5 +/- 11.7 (P < 0.02) occurred i

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