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Sirtuin 6 Protects Against Oxidative Stress and Vascular Dysfunction in Mice.
Greiten LE, Zhang B, Roos CM, Hagler M, Jahns FP, Miller JD. Greiten LE, et al. Front Physiol. 2021 Oct 20;12:753501. doi: 10.3389/fphys.2021.753501. eCollection 2021. Front Physiol. 2021. PMID: 34744793 Free PMC article.

Relaxation in response to acetylcholine (ACH) was impaired in HET mice compared to littermate-matched WT controls (67 3% versus 76 3%, respectively; p < 0.05), while responses to sodium nitroprusside were unchanged. Short-term incubation of carotid rings with the NAD(P)

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Relaxation in response to acetylcholine (ACH) was impaired in HET mice compared to littermate-matched WT controls (67 3% versus 76 3%, respe …
Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.
Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK. Schafer MJ, et al. Diabetes. 2016 Jun;65(6):1606-15. doi: 10.2337/db15-0291. Epub 2016 Mar 16. Diabetes. 2016. PMID: 26983960 Free PMC article.
We show that exercise prevents the accumulation of senescent cells and the expression of the SASP while nullifying the damaging effects of the FFD on parameters of health. We also demonstrate that exercise initiated after long-term FFD feeding reduces senescent phenotype m …
We show that exercise prevents the accumulation of senescent cells and the expression of the SASP while nullifying the damaging effects of t …
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.
Roos CM, Zhang B, Palmer AK, Ogrodnik MB, Pirtskhalava T, Thalji NM, Hagler M, Jurk D, Smith LA, Casaclang-Verzosa G, Zhu Y, Schafer MJ, Tchkonia T, Kirkland JL, Miller JD. Roos CM, et al. Aging Cell. 2016 Oct;15(5):973-7. doi: 10.1111/acel.12458. Epub 2016 Aug 5. Aging Cell. 2016. PMID: 26864908 Free PMC article.
While reports suggest a single dose of senolytics may improve vasomotor function, the structural and functional impact of long-term senolytic treatment is unknown. To determine whether long-term senolytic treatment improves vasomotor function, vascular stiffness, an …
While reports suggest a single dose of senolytics may improve vasomotor function, the structural and functional impact of long-term s …