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Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation.
Kelly RM, Goren EM, Taylor PA, Mueller SN, Stefanski HE, Osborn MJ, Scott HS, Komarova EA, Gudkov AV, Holländer GA, Blazar BR. Kelly RM, et al. Blood. 2010 Feb 4;115(5):1088-97. doi: 10.1182/blood-2009-05-223198. Epub 2009 Dec 4. Blood. 2010. PMID: 19965631 Free PMC article.
Long-term follow-up of a phase I/II randomized, placebo-controlled trial of palifermin to prevent graft-versus-host disease (GVHD) after related donor allogeneic hematopoietic cell transplantation (HCT).
Levine JE, Blazar BR, DeFor T, Ferrara JLM, Weisdorf DJ. Levine JE, et al. Biol Blood Marrow Transplant. 2008 Sep;14(9):1017-1021. doi: 10.1016/j.bbmt.2008.06.013. Biol Blood Marrow Transplant. 2008. PMID: 18721764 Free PMC article. Clinical Trial.
We found no differences in CMV or invasive fungal infections, chronic GVHD, or long-term survival between cohorts. We conclude that the benefits of palifermin appear primarily to be limited to ameliorating mucotoxicity when given to allogeneic HCT recipients....
We found no differences in CMV or invasive fungal infections, chronic GVHD, or long-term survival between cohorts. We conclude that t …
Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells.
Serafini M, Dylla SJ, Oki M, Heremans Y, Tolar J, Jiang Y, Buckley SM, Pelacho B, Burns TC, Frommer S, Rossi DJ, Bryder D, Panoskaltsis-Mortari A, O'Shaughnessy MJ, Nelson-Holte M, Fine GC, Weissman IL, Blazar BR, Verfaillie CM. Serafini M, et al. J Exp Med. 2007 Jan 22;204(1):129-39. doi: 10.1084/jem.20061115. Epub 2007 Jan 16. J Exp Med. 2007. PMID: 17227908 Free PMC article.