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M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion.
Luo Y, Shao L, Chang J, Feng W, Liu YL, Cottler-Fox MH, Emanuel PD, Hauer-Jensen M, Bernstein ID, Liu L, Chen X, Zhou J, Murray PJ, Zhou D. Luo Y, et al. Blood Adv. 2018 Apr 24;2(8):859-870. doi: 10.1182/bloodadvances.2018015685. Blood Adv. 2018. PMID: 29666049 Free PMC article.
Importantly, coculture of hUCB CD34(+) cells with human M2-Mphis for 8 days resulted in 28.7- and 6.6-fold increases in the number of CD34(+) cells and long-term SCID mice-repopulating cells, respectively, compared with uncultured hUCB CD34(+) cells. ...
Importantly, coculture of hUCB CD34(+) cells with human M2-Mphis for 8 days resulted in 28.7- and 6.6-fold increases in the number of CD34(+ …
Low doses of oxygen ion irradiation cause long-term damage to bone marrow hematopoietic progenitor and stem cells in mice.
Wang Y, Chang J, Li X, Pathak R, Sridharan V, Jones T, Mao XW, Nelson G, Boerma M, Hauer-Jensen M, Zhou D, Shao L. Wang Y, et al. PLoS One. 2017 Dec 12;12(12):e0189466. doi: 10.1371/journal.pone.0189466. eCollection 2017. PLoS One. 2017. PMID: 29232383 Free PMC article.
However, the chronic effects of low dose 16O irradiation remain undefined. In the current study, we investigated the long-term effects of low dose 16O irradiation on the mouse hematopoietic system. ...These data suggest that exposure to low doses of 16O irradiation induces …
However, the chronic effects of low dose 16O irradiation remain undefined. In the current study, we investigated the long-term effect …
Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.
Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J. Demaria M, et al. Cancer Discov. 2017 Feb;7(2):165-176. doi: 10.1158/2159-8290.CD-16-0241. Epub 2016 Dec 15. Cancer Discov. 2017. PMID: 27979832 Free PMC article.
Using a transgenic mouse that permits tracking and eliminating senescent cells, we show that therapy-induced senescent (TIS) cells persist and contribute to local and systemic inflammation. Eliminating TIS cells reduced several short- and long-term effects of the drugs, in …
Using a transgenic mouse that permits tracking and eliminating senescent cells, we show that therapy-induced senescent (TIS) cells persist a …
Granulocyte colony-stimulating factor exacerbates hematopoietic stem cell injury after irradiation.
Li C, Lu L, Zhang J, Huang S, Xing Y, Zhao M, Zhou D, Li D, Meng A. Li C, et al. Cell Biosci. 2015 Nov 25;5:65. doi: 10.1186/s13578-015-0057-3. eCollection 2015. Cell Biosci. 2015. PMID: 26609358 Free PMC article.
BACKGROUND: Exposure to a moderate to high dose of ionizing radiation (IR) not only causes acute radiation syndrome but also induces long-term (LT) bone marrow (BM) injury. The latter effect of IR is primarily attributed to the induction of hematopoietic stem cell (HSC) se …
BACKGROUND: Exposure to a moderate to high dose of ionizing radiation (IR) not only causes acute radiation syndrome but also induces long- …
Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.
Xu G, Wu H, Zhang J, Li D, Wang Y, Wang Y, Zhang H, Lu L, Li C, Huang S, Xing Y, Zhou D, Meng A. Xu G, et al. Free Radic Biol Med. 2015 Oct;87:15-25. doi: 10.1016/j.freeradbiomed.2015.05.045. Epub 2015 Jun 16. Free Radic Biol Med. 2015. PMID: 26086617 Free PMC article.
These findings demonstrate that metformin can attenuate TBI-induced long-term BM injury at least in part by inhibiting the induction of chronic oxidative stress in HSCs and HSC senescence. Therefore, metformin has the potential to be used as a novel radioprotectant to amel …
These findings demonstrate that metformin can attenuate TBI-induced long-term BM injury at least in part by inhibiting the induction …
Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner.
Shao L, Feng W, Li H, Gardner D, Luo Y, Wang Y, Liu L, Meng A, Sharpless NE, Zhou D. Shao L, et al. Blood. 2014 May 15;123(20):3105-15. doi: 10.1182/blood-2013-07-515619. Epub 2014 Mar 12. Blood. 2014. PMID: 24622326 Free PMC article.
Exposure to total body irradiation (TBI) induces not only acute hematopoietic radiation syndrome but also long-term or residual bone marrow (BM) injury. This residual BM injury is mainly attributed to permanent damage to hematopoietic stem cells (HSCs), including impaired …
Exposure to total body irradiation (TBI) induces not only acute hematopoietic radiation syndrome but also long-term or residual bone …
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury.
Shao L, Wang Y, Chang J, Luo Y, Meng A, Zhou D. Shao L, et al. Transl Cancer Res. 2013 Oct;2(5):397-411. doi: 10.3978/j.issn.2218-676X.2013.07.03. Transl Cancer Res. 2013. PMID: 24605290 Free PMC article.
Due to improvements in early detection and treatment of cancer, the number of long-term cancer survivors is increasing. Unfortunately, these survivors are at increased risk for developing cancer treatment-related late effects, including ionizing radiation (IR)- and chemoth …
Due to improvements in early detection and treatment of cancer, the number of long-term cancer survivors is increasing. Unfortunately …
Hematopoietic stem cell injury induced by ionizing radiation.
Shao L, Luo Y, Zhou D. Shao L, et al. Antioxid Redox Signal. 2014 Mar 20;20(9):1447-62. doi: 10.1089/ars.2013.5635. Epub 2014 Feb 10. Antioxid Redox Signal. 2014. PMID: 24124731 Free PMC article. Review.
CRITICAL ISSUES: Induction of apoptosis in HSCs and hematopoietic progenitor cells is primarily responsible for IR-induced acute bone marrow (BM) injury. Long-term BM suppression caused by IR is mainly attributable to the induction of HSC senescence. However, the promotion …
CRITICAL ISSUES: Induction of apoptosis in HSCs and hematopoietic progenitor cells is primarily responsible for IR-induced acute bone marrow …
Resveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.
Zhang H, Zhai Z, Wang Y, Zhang J, Wu H, Wang Y, Li C, Li D, Lu L, Wang X, Chang J, Hou Q, Ju Z, Zhou D, Meng A. Zhang H, et al. Free Radic Biol Med. 2013 Jan;54:40-50. doi: 10.1016/j.freeradbiomed.2012.10.530. Epub 2012 Nov 1. Free Radic Biol Med. 2013. PMID: 23124026 Free PMC article.
Our recent studies showed that total body irradiation (TBI) induces long-term bone marrow (BM) suppression in part by induction of hematopoietic stem cell (HSC) senescence through NADPH oxidase 4 (NOX4)-derived reactive oxygen species (ROS). ...Therefore, resveratrol has t …
Our recent studies showed that total body irradiation (TBI) induces long-term bone marrow (BM) suppression in part by induction of he …
Inhibition of p38 MAPK attenuates ionizing radiation-induced hematopoietic cell senescence and residual bone marrow injury.
Wang Y, Liu L, Zhou D. Wang Y, et al. Radiat Res. 2011 Dec;176(6):743-52. doi: 10.1667/rr2727.1. Epub 2011 Oct 20. Radiat Res. 2011. PMID: 22014293 Free PMC article.
Exposure to a moderate or high total-body dose of radiation induces not only acute bone marrow suppression but also residual (or long-term) bone marrow injury. The induction of residual bone marrow injury is primarily attributed to the induction of hematopoietic cell senes …
Exposure to a moderate or high total-body dose of radiation induces not only acute bone marrow suppression but also residual (or long-ter …
12 results