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Page 1
Long-Term Skeletal Muscle Mitochondrial Dysfunction is Associated with Hypermetabolism in Severely Burned Children.
Porter C, Herndon DN, Børsheim E, Bhattarai N, Chao T, Reidy PT, Rasmussen BB, Andersen CR, Suman OE, Sidossis LS. Porter C, et al. J Burn Care Res. 2016 Jan-Feb;37(1):53-63. doi: 10.1097/BCR.0000000000000308. J Burn Care Res. 2016. PMID: 26361327 Free PMC article.
The long-term impact of burn trauma on skeletal muscle bioenergetics remains unknown. ...These quantitative and qualitative derangements in skeletal muscle bioenergetics likely contribute to the long-term pathophysiological stress response to burn trauma....
The long-term impact of burn trauma on skeletal muscle bioenergetics remains unknown. ...These quantitative and qualitative derangeme …
Rapamycin does not affect post-absorptive protein metabolism in human skeletal muscle.
Dickinson JM, Drummond MJ, Fry CS, Gundermann DM, Walker DK, Timmerman KL, Volpi E, Rasmussen BB. Dickinson JM, et al. Metabolism. 2013 Jan;62(1):144-51. doi: 10.1016/j.metabol.2012.07.003. Epub 2012 Sep 6. Metabolism. 2013. PMID: 22959478 Free PMC article. Clinical Trial.
Thus, post-absorptive muscle protein metabolism and mTORC1 signaling were not affected by rapamycin administration. CONCLUSIONS: Short-term rapamycin administration may only impair protein synthesis in human skeletal muscle when combined with a stimulus such as resistance …
Thus, post-absorptive muscle protein metabolism and mTORC1 signaling were not affected by rapamycin administration. CONCLUSIONS: Short-te …
Gene and protein expression associated with protein synthesis and breakdown in paraplegic skeletal muscle.
Drummond MJ, Glynn EL, Lujan HL, Dicarlo SE, Rasmussen BB. Drummond MJ, et al. Muscle Nerve. 2008 Apr;37(4):505-13. doi: 10.1002/mus.20976. Muscle Nerve. 2008. PMID: 18236467 Free PMC article.
Spinal cord injury reduces the rate of skeletal muscle protein synthesis and increases protein breakdown, resulting in rapid muscle loss. The purpose of this study was to determine whether long-term paraplegia would eventually result in a downregulation of muscle mRNA and …
Spinal cord injury reduces the rate of skeletal muscle protein synthesis and increases protein breakdown, resulting in rapid muscle loss. Th …
Chronic paraplegia-induced muscle atrophy downregulates the mTOR/S6K1 signaling pathway.
Dreyer HC, Glynn EL, Lujan HL, Fry CS, DiCarlo SE, Rasmussen BB. Dreyer HC, et al. J Appl Physiol (1985). 2008 Jan;104(1):27-33. doi: 10.1152/japplphysiol.00736.2007. Epub 2007 Sep 20. J Appl Physiol (1985). 2008. PMID: 17885021 Free PMC article.
Therefore, in addition to upregulation of atrophy signaling during muscle wasting, downregulation of muscle cell growth/hypertrophy-associated signaling appears to be an important component of long-term muscle loss....
Therefore, in addition to upregulation of atrophy signaling during muscle wasting, downregulation of muscle cell growth/hypertrophy-associat …
Short-term insulin and nutritional energy provision do not stimulate muscle protein synthesis if blood amino acid availability decreases.
Bell JA, Fujita S, Volpi E, Cadenas JG, Rasmussen BB. Bell JA, et al. Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E999-1006. doi: 10.1152/ajpendo.00170.2005. Epub 2005 Jul 19. Am J Physiol Endocrinol Metab. 2005. PMID: 16030064 Free PMC article.
Muscle protein synthesis requires energy and amino acids to proceed and can be stimulated by insulin under certain circumstances. We hypothesized that short-term provision of insulin and nutritional energy would stimulate muscle protein synthesis in healthy subjects only i …
Muscle protein synthesis requires energy and amino acids to proceed and can be stimulated by insulin under certain circumstances. We hypothe …