FTY720 markedly increases alloengraftment but does not eliminate host anti-donor T cells that cause graft rejection on its withdrawal.
Biol Blood Marrow Transplant. 2012 Sep;18(9):1341-52. doi: 10.1016/j.bbmt.2012.06.007. Epub 2012 Jun 19.
Biol Blood Marrow Transplant. 2012.
PMID: 22728248
Free PMC article.
In contrast to FTY alone, the combination of anti-CD40L mAb and FTY resulted in a surprisingly stable, multilineage, long-term donor chimerism. These data illustrate FTY's profound migration modulating effects and suggest a use in combinatorial therapy in achieving stable …
In contrast to FTY alone, the combination of anti-CD40L mAb and FTY resulted in a surprisingly stable, multilineage, long-term donor …