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Mitochondrial proteostasis in the control of aging and longevity.
Jensen MB, Jasper H. Jensen MB, et al. Cell Metab. 2014 Aug 5;20(2):214-25. doi: 10.1016/j.cmet.2014.05.006. Epub 2014 Jun 12. Cell Metab. 2014. PMID: 24930971 Free PMC article. Review.
These findings center on the mitochondrial unfolded protein response (UPR(mt)), which has been implicated in lifespan extension in worms, flies, and mice, suggesting a conserved role in the long-term maintenance of cellular homeostasis. Here, we review current knowledge of …
These findings center on the mitochondrial unfolded protein response (UPR(mt)), which has been implicated in lifespan extension in worms, fl …
Maintaining tissue homeostasis: dynamic control of somatic stem cell activity.
Biteau B, Hochmuth CE, Jasper H. Biteau B, et al. Cell Stem Cell. 2011 Nov 4;9(5):402-11. doi: 10.1016/j.stem.2011.10.004. Cell Stem Cell. 2011. PMID: 22056138 Free PMC article. Review.
Long-term maintenance of tissue homeostasis relies on the accurate regulation of somatic stem cell activity. ...
Long-term maintenance of tissue homeostasis relies on the accurate regulation of somatic stem cell activity. ...
Insulin and JNK: optimizing metabolic homeostasis and lifespan.
Karpac J, Jasper H. Karpac J, et al. Trends Endocrinol Metab. 2009 Apr;20(3):100-6. doi: 10.1016/j.tem.2008.11.004. Epub 2009 Feb 27. Trends Endocrinol Metab. 2009. PMID: 19251431 Free PMC article. Review.
Metabolic adaptation to environmental changes is crucial for the long-term survival of an organism. Signaling mechanisms that govern this adaptation thus influence lifespan. ...
Metabolic adaptation to environmental changes is crucial for the long-term survival of an organism. Signaling mechanisms that govern …