Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2010 2
2012 1
2013 1
2014 1
2017 1
2021 2
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

7 results

Results by year

Filters applied: . Clear all
Page 1
SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3.
Tripathi U, Nchioua R, Prata LGPL, Zhu Y, Gerdes EOW, Giorgadze N, Pirtskhalava T, Parker E, Xue A, Espindola-Netto JM, Stenger S, Robbins PD, Niedernhofer LJ, Dickinson SL, Allison DB, Kirchhoff F, Sparrer KMJ, Tchkonia T, Kirkland JL. Tripathi U, et al. Aging (Albany NY). 2021 Sep 16;13(18):21838-21854. doi: 10.18632/aging.203560. Epub 2021 Sep 16. Aging (Albany NY). 2021. PMID: 34531331 Free PMC article.
Our results suggest that induction of cellular senescence and SASP amplification through TLR-3 contribute to SARS-CoV-2 morbidity, indicating that clinical trials of senolytics and/or SASP/TLR-3 inhibitors for alleviating acute and long-term SARS-CoV-2 sequelae are warrant …
Our results suggest that induction of cellular senescence and SASP amplification through TLR-3 contribute to SARS-CoV-2 morbidity, indicatin …
Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era.
Verdoorn BP, Evans TK, Hanson GJ, Zhu Y, Langhi Prata LGP, Pignolo RJ, Atkinson EJ, Wissler-Gerdes EO, Kuchel GA, Mannick JB, Kritchevsky SB, Khosla S, Rizza SA, Walston JD, Musi N, Lipsitz LA, Kiel DP, Yung R, LeBrasseur NK, Singh RJ, McCarthy T, Puskarich MA, Niedernhofer LJ, Robbins PD, Sorenson M, Tchkonia T, Kirkland JL. Verdoorn BP, et al. J Am Geriatr Soc. 2021 Nov;69(11):3023-3033. doi: 10.1111/jgs.17416. Epub 2021 Aug 20. J Am Geriatr Soc. 2021. PMID: 34375437 Free PMC article.
We consider logistic challenges of conducting trials in long-term care settings in the SARS-CoV-2 era, including restricted access, consent procedures, methods for obtaining biospecimens and clinical data, staffing, investigational product administration issues, and potent …
We consider logistic challenges of conducting trials in long-term care settings in the SARS-CoV-2 era, including restricted access, c …
The Clinical Potential of Senolytic Drugs.
Kirkland JL, Tchkonia T, Zhu Y, Niedernhofer LJ, Robbins PD. Kirkland JL, et al. J Am Geriatr Soc. 2017 Oct;65(10):2297-2301. doi: 10.1111/jgs.14969. Epub 2017 Sep 4. J Am Geriatr Soc. 2017. PMID: 28869295 Free PMC article.
To do so, new clinical trial paradigms for testing senolytics and other agents that target fundamental aging mechanisms are being developed, because use of long-term endpoints such as lifespan or healthspan is not feasible. These strategies include testing effects on multi …
To do so, new clinical trial paradigms for testing senolytics and other agents that target fundamental aging mechanisms are being developed, …
Effects of thiol antioxidant β-mercaptoethanol on diet-induced obese mice.
Wong S, Kirkland JL, Schwanz HA, Simmons AL, Hamilton JA, Corkey BE, Guo W. Wong S, et al. Life Sci. 2014 Jun 27;107(1-2):32-41. doi: 10.1016/j.lfs.2014.04.031. Epub 2014 May 5. Life Sci. 2014. PMID: 24802126 Free PMC article.
However, treatments of obese subjects with different types of antioxidants often give mixed outcomes. In this work, we sought to determine if long-term supplementation of a thiol antioxidant, beta-mercaptoethanol, to diet-induced obese mice may improve their health conditi …
However, treatments of obese subjects with different types of antioxidants often give mixed outcomes. In this work, we sought to determine i …
Translating advances from the basic biology of aging into clinical application.
Kirkland JL. Kirkland JL. Exp Gerontol. 2013 Jan;48(1):1-5. doi: 10.1016/j.exger.2012.11.014. Epub 2012 Dec 10. Exp Gerontol. 2013. PMID: 23237984 Free PMC article. Review.
Focusing on subjects with symptoms of age-related diseases or frailty or who are at imminent risk of developing these problems, measuring effects on short-term, clinically relevant outcomes, as opposed to long-term outcomes such as healthspan or lifespan, and develo …
Focusing on subjects with symptoms of age-related diseases or frailty or who are at imminent risk of developing these problems, measuring ef …