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Exogenous hydrogen sulfide attenuates hyperoxia effects on neonatal mouse airways.
Bartman CM, Schiliro M, Nesbitt L, Lee KK, Prakash YS, Pabelick CM. Bartman CM, et al. Among authors: prakash ys. Am J Physiol Lung Cell Mol Physiol. 2024 Jan 1;326(1):L52-L64. doi: 10.1152/ajplung.00196.2023. Epub 2023 Nov 21. Am J Physiol Lung Cell Mol Physiol. 2024. PMID: 37987780
Moderate hyperoxia promotes AHR via effects on airway smooth muscle (ASM), a cell type that also contributes to impaired bronchodilation and remodeling (proliferation, altered extracellular matrix). Understanding mechanisms by which O(2) initiates long-term airway changes …
Moderate hyperoxia promotes AHR via effects on airway smooth muscle (ASM), a cell type that also contributes to impaired bronchodilation and …
Piezo channels in stretch effects on developing human airway smooth muscle.
Kelley B, Zhang EY, Khalfaoui L, Schiliro M, Wells N, Pabelick CM, Prakash YS, Vogel ER. Kelley B, et al. Among authors: prakash ys. Am J Physiol Lung Cell Mol Physiol. 2023 Nov 1;325(5):L542-L551. doi: 10.1152/ajplung.00008.2023. Epub 2023 Sep 12. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 37697925
The use of respiratory support strategies such as continuous positive airway pressure in premature infants can substantially stretch highly compliant perinatal airways, leading to airway hyperreactivity and remodeling in the long term. The mechanisms by which stretch detri …
The use of respiratory support strategies such as continuous positive airway pressure in premature infants can substantially stretch highly …
CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3.
Mayer CA, Ganguly A, Mayer A, Pabelick CM, Prakash YS, Hascall VC, Midura RJ, Cali V, Flask CA, Erokwu BO, Martin RJ, MacFarlane PM. Mayer CA, et al. Among authors: prakash ys. Pediatr Res. 2022 Sep;92(3):685-693. doi: 10.1038/s41390-021-01695-0. Epub 2021 Nov 8. Pediatr Res. 2022. PMID: 34750521 Free PMC article.
BACKGROUND: Continuous positive airway pressure (CPAP) is a primary mode of respiratory support for preterm infants. Animal studies have shown long-term detrimental effects on lung/airway development, particularly airway (AW) hyper-reactivity, as an unfortunate consequence …
BACKGROUND: Continuous positive airway pressure (CPAP) is a primary mode of respiratory support for preterm infants. Animal studies have sho …
Calcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice.
Mayer CA, Roos B, Teske J, Wells N, Martin RJ, Chang W, Pabelick CM, Prakash YS, MacFarlane PM. Mayer CA, et al. Among authors: prakash ys. Pediatr Res. 2022 May;91(6):1391-1398. doi: 10.1038/s41390-021-01540-4. Epub 2021 May 6. Pediatr Res. 2022. PMID: 33958714 Free PMC article.
BACKGROUND: Continuous positive airway pressure (CPAP) in preterm infants is initially beneficial, but animal models suggest longer term detrimental airway effects towards asthma. We used a neonatal CPAP mouse model and human fetal airway smooth muscle (ASM) to investigate …
BACKGROUND: Continuous positive airway pressure (CPAP) in preterm infants is initially beneficial, but animal models suggest longer term …
Estrogen receptors differentially regulate intracellular calcium handling in human nonasthmatic and asthmatic airway smooth muscle cells.
Bhallamudi S, Connell J, Pabelick CM, Prakash YS, Sathish V. Bhallamudi S, et al. Among authors: prakash ys. Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L112-L124. doi: 10.1152/ajplung.00206.2019. Epub 2019 Oct 16. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 31617730 Free PMC article.
Previous studies suggested rapid, nongenomic signaling of estrogen via ERs reduces intracellular calcium ([Ca(2+)](i)), thereby promoting relaxation of ASM. However, long-term ER activation on [Ca(2+)](i) regulation in human ASM during inflammation or in asthma is still no …
Previous studies suggested rapid, nongenomic signaling of estrogen via ERs reduces intracellular calcium ([Ca(2+)](i)), thereby promoting re …
Neonatal hyperoxia promotes asthma-like features through IL-33-dependent ILC2 responses.
Cheon IS, Son YM, Jiang L, Goplen NP, Kaplan MH, Limper AH, Kita H, Paczesny S, Prakash YS, Tepper R, Ahlfeld SK, Sun J. Cheon IS, et al. Among authors: prakash ys. J Allergy Clin Immunol. 2018 Oct;142(4):1100-1112. doi: 10.1016/j.jaci.2017.11.025. Epub 2017 Dec 15. J Allergy Clin Immunol. 2018. PMID: 29253513 Free PMC article.
Assessments were performed at various time points for evaluation of airway hyperresponsiveness, eosinophilia, mucus production, inflammatory gene expression, and T(H) and group 2 innate lymphoid cell (ILC2) responses. Sera from term- and preterm-born infants were also coll …
Assessments were performed at various time points for evaluation of airway hyperresponsiveness, eosinophilia, mucus production, inflammatory …
Functional Effects of Cigarette Smoke-Induced Changes in Airway Smooth Muscle Mitochondrial Morphology.
Aravamudan B, Thompson M, Sieck GC, Vassallo R, Pabelick CM, Prakash YS. Aravamudan B, et al. Among authors: prakash ys. J Cell Physiol. 2017 May;232(5):1053-1068. doi: 10.1002/jcp.25508. Epub 2016 Sep 21. J Cell Physiol. 2017. PMID: 27474898 Free PMC article.
Long-term exposure to cigarette smoke (CS) triggers airway hyperreactivity and remodeling, effects that involve airway smooth muscle (ASM). ...
Long-term exposure to cigarette smoke (CS) triggers airway hyperreactivity and remodeling, effects that involve airway smooth muscle …
The Effect of Continuous Positive Airway Pressure in a Mouse Model of Hyperoxic Neonatal Lung Injury.
Reyburn B, Di Fiore JM, Raffay T, Martin RJ, Prakash YS, Jafri A, MacFarlane PM. Reyburn B, et al. Among authors: prakash ys. Neonatology. 2016;109(1):6-13. doi: 10.1159/000438818. Epub 2015 Sep 23. Neonatology. 2016. PMID: 26394387 Free PMC article.
Although oxygen therapy is associated with respiratory morbidities including bronchopulmonary dysplasia (BPD), the long-term effects of CPAP on lung function are largely unknown. We used a hyperoxia-induced mouse model of BPD to explore the effects of daily CPAP in the fir …
Although oxygen therapy is associated with respiratory morbidities including bronchopulmonary dysplasia (BPD), the long-term effects …
Coming to terms with tissue engineering and regenerative medicine in the lung.
Prakash YS, Tschumperlin DJ, Stenmark KR. Prakash YS, et al. Am J Physiol Lung Cell Mol Physiol. 2015 Oct 1;309(7):L625-38. doi: 10.1152/ajplung.00204.2015. Epub 2015 Aug 7. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 26254424 Free PMC article. Review.
However, limited donor lung availability, graft rejection, and long-term problems after transplantation are major hurdles to lung transplantation being a panacea. ...
However, limited donor lung availability, graft rejection, and long-term problems after transplantation are major hurdles to lung tra …
Mechanisms of Cigarette Smoke Effects on Human Airway Smooth Muscle.
Wylam ME, Sathish V, VanOosten SK, Freeman M, Burkholder D, Thompson MA, Pabelick CM, Prakash YS. Wylam ME, et al. Among authors: prakash ys. PLoS One. 2015 Jun 15;10(6):e0128778. doi: 10.1371/journal.pone.0128778. eCollection 2015. PLoS One. 2015. PMID: 26075746 Free PMC article.
CSE also increased hASM ROS generation and cytokine secretion. In addition, we found in the airways of patients with long-term smoking history, TRPC3 and CD38 expression were significantly increased compared to life-long never-smokers, supporting the role of these proteins …
CSE also increased hASM ROS generation and cytokine secretion. In addition, we found in the airways of patients with long-term smokin …
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