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Low baseline ribosome-related gene expression and resistance training-induced declines in ribosome-related gene expression are associated with skeletal muscle hypertrophy in young men and women.
Brown A, Parise G, Thomas ACQ, Ng SY, McGlory C, Phillips SM, Kumbhare D, Joanisse S. Brown A, et al. Among authors: phillips sm. J Cell Physiol. 2024 Apr;239(4):e31182. doi: 10.1002/jcp.31182. Epub 2024 Jan 12. J Cell Physiol. 2024. PMID: 38214457
This may point to the importance of translational efficiency rather than translational capacity (i.e. ribosome content) in mediating long-term exercise-induced adaptations in skeletal muscle....
This may point to the importance of translational efficiency rather than translational capacity (i.e. ribosome content) in mediating long- …
Current evidence shows no influence of women's menstrual cycle phase on acute strength performance or adaptations to resistance exercise training.
Colenso-Semple LM, D'Souza AC, Elliott-Sale KJ, Phillips SM. Colenso-Semple LM, et al. Among authors: phillips sm. Front Sports Act Living. 2023 Mar 23;5:1054542. doi: 10.3389/fspor.2023.1054542. eCollection 2023. Front Sports Act Living. 2023. PMID: 37033884 Free PMC article. Review.
DISCUSSION: We highlight the importance of comprehensive menstrual cycle verification methods, as we noted a pattern of poor and inconsistent methodological practices in the literature. In our opinion, it is premature to conclude that short-term fluctuations in reproductiv …
DISCUSSION: We highlight the importance of comprehensive menstrual cycle verification methods, as we noted a pattern of poor and inconsisten …
An elusive consensus definition of sarcopenia impedes research and clinical treatment: A narrative review.
Coletta G, Phillips SM. Coletta G, et al. Among authors: phillips sm. Ageing Res Rev. 2023 Apr;86:101883. doi: 10.1016/j.arr.2023.101883. Epub 2023 Feb 13. Ageing Res Rev. 2023. PMID: 36792012 Free article. Review.
The definition of sarcopenia, the age-related loss of muscle mass, has evolved since the term's inception and yet there is no consensus. Many of the identified definitions of sarcopenia centre their criteria around the loss of muscle mass, loss of function, and weakness. . …
The definition of sarcopenia, the age-related loss of muscle mass, has evolved since the term's inception and yet there is no consens …
Increased protein intake derived from leucine-enriched protein enhances the integrated myofibrillar protein synthetic response to short-term resistance training in untrained men and women: a 4-day randomized controlled trial.
Lim C, Traylor DA, McGlory C, Joanisse S, McKendry J, Grewal T, Mcleod JC, Prior T, Nunes EA, Lees M, Phillips SM. Lim C, et al. Among authors: phillips sm. Appl Physiol Nutr Metab. 2022 Nov 1;47(11):1104-1114. doi: 10.1139/apnm-2022-0164. Epub 2022 Sep 20. Appl Physiol Nutr Metab. 2022. PMID: 36126327 Clinical Trial.
The consumption of higher leucine-containing drinks stimulates MyoPS, but we know less about higher leucine solid foods. Here, we examined the effect of short-term resistance exercise training (STRT) combined with supplementation of a protein and leucine-enriched bar, comp …
The consumption of higher leucine-containing drinks stimulates MyoPS, but we know less about higher leucine solid foods. Here, we examined t …
Declines in muscle protein synthesis account for short-term muscle disuse atrophy in humans in the absence of increased muscle protein breakdown.
Brook MS, Stokes T, Gorissen SHM, Bass JJ, McGlory C, Cegielski J, Wilkinson DJ, Phillips BE, Smith K, Phillips SM, Atherton PJ. Brook MS, et al. Among authors: phillips sm. J Cachexia Sarcopenia Muscle. 2022 Aug;13(4):2005-2016. doi: 10.1002/jcsm.13005. Epub 2022 May 23. J Cachexia Sarcopenia Muscle. 2022. PMID: 35606155 Free PMC article.
BACKGROUND: We determined the short-term (i.e. 4 days) impacts of disuse atrophy in relation to muscle protein turnover [acute fasted-fed muscle protein synthesis (MPS)/muscle protein breakdown (MPB) and integrated MPS/estimated MPB]. ...
BACKGROUND: We determined the short-term (i.e. 4 days) impacts of disuse atrophy in relation to muscle protein turnover [acute fasted …
Group-based nutrition interventions to promote healthy eating and mobility in community-dwelling older adults: a systematic review.
Teggart K, Ganann R, Sihota D, Moore C, Keller H, Senson C, Phillips SM, Neil-Sztramko SE. Teggart K, et al. Among authors: phillips sm. Public Health Nutr. 2022 May 16;25(10):1-32. doi: 10.1017/S136898002200115X. Online ahead of print. Public Health Nutr. 2022. PMID: 35570675 Free PMC article. Review.
SETTING: Nutrition interventions delivered to groups in community-based settings were eligible. Studies delivered in acute or long-term care settings were excluded. PARTICIPANTS: Community-dwelling older adults aged 55+ years. ...
SETTING: Nutrition interventions delivered to groups in community-based settings were eligible. Studies delivered in acute or long-term …
A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease.
Timmons JA, Anighoro A, Brogan RJ, Stahl J, Wahlestedt C, Farquhar DG, Taylor-King J, Volmar CH, Kraus WE, Phillips SM. Timmons JA, et al. Among authors: phillips sm. Elife. 2022 Jan 17;11:e68832. doi: 10.7554/eLife.68832. Elife. 2022. PMID: 35037854 Free PMC article.
Cross-referencing these results with the way existing drugs act on gene activity, highlighted 138 compounds that directly bind 73 proteins responsible for regulating insulin resistance pathways. Some of the drugs identified are suitable for short-term clinical studies, and …
Cross-referencing these results with the way existing drugs act on gene activity, highlighted 138 compounds that directly bind 73 proteins r …
The importance of protein sources to support muscle anabolism in cancer: An expert group opinion.
Ford KL, Arends J, Atherton PJ, Engelen MPKJ, Gonçalves TJM, Laviano A, Lobo DN, Phillips SM, Ravasco P, Deutz NEP, Prado CM. Ford KL, et al. Among authors: phillips sm. Clin Nutr. 2022 Jan;41(1):192-201. doi: 10.1016/j.clnu.2021.11.032. Epub 2021 Nov 29. Clin Nutr. 2022. PMID: 34891022 Free article. Review.
., vegan) diet upon a diagnosis of cancer, given the presence of elevated protein requirements and risk of inadequate protein intake to support muscle anabolism. Amino acid combination and the long-term sustainability of a dietary pattern void of animal-based foods require …
., vegan) diet upon a diagnosis of cancer, given the presence of elevated protein requirements and risk of inadequate protein intake to supp …
Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans.
Willis CRG, Gallagher IJ, Wilkinson DJ, Brook MS, Bass JJ, Phillips BE, Smith K, Etheridge T, Stokes T, McGlory C, Gorissen SHM, Szewczyk NJ, Phillips SM, Atherton PJ. Willis CRG, et al. Among authors: phillips sm. FASEB J. 2021 Sep;35(9):e21830. doi: 10.1096/fj.202100276RR. FASEB J. 2021. PMID: 34342902
Notably, we implicate a putative role for muscle protein breakdown-related molecular networks in impairing MPS during short-term disuse, and further establish DEPTOR (a potent mTOR inhibitor) as a critical mechanistic candidate of disuse driven MPS suppression in humans. O …
Notably, we implicate a putative role for muscle protein breakdown-related molecular networks in impairing MPS during short-term disu …
68 results