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Characterization and preclinical evaluation of the cGMP grade DNA based vaccine, AV-1959D to enter the first-in-human clinical trials.
Neurobiol Dis. 2020 Jun;139:104823. doi: 10.1016/j.nbd.2020.104823. Epub 2020 Feb 28.
Neurobiol Dis. 2020.
PMID: 32119976
Free PMC article.
Review.
In Tg2576 mice with established amyloid pathology, we did not observe short- or long-term toxicities after multiple immunizations with three doses of AV-1959D. ...
In Tg2576 mice with established amyloid pathology, we did not observe short- or long-term toxicities after multiple immunizations wit …
Epitope-based DNA vaccine for Alzheimer's disease: translational study in macaques.
Evans CF, Davtyan H, Petrushina I, Hovakimyan A, Davtyan A, Hannaman D, Cribbs DH, Agadjanyan MG, Ghochikyan A.
Evans CF, et al. Among authors: petrushina i.
Alzheimers Dement. 2014 May;10(3):284-95. doi: 10.1016/j.jalz.2013.04.505. Epub 2013 Jul 31.
Alzheimers Dement. 2014.
PMID: 23916838
Free PMC article.
Functional activities of anti-Abeta antibodies generated in response to vaccination were assessed in vitro. RESULTS: AV-1955 generates long-term, potent anti-Abeta antibodies and cellular immune responses specific to foreign T-helper epitopes but not to self-Abeta. ...
Functional activities of anti-Abeta antibodies generated in response to vaccination were assessed in vitro. RESULTS: AV-1955 generates long- …
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