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Telemetric assessment of referred vaginal hyperalgesia and the effect of indomethacin in a rat model of endometriosis.
Dmitrieva N, Faircloth EK, Pyatok S, Sacher F, Patchev V. Dmitrieva N, et al. Among authors: patchev v. Front Pharmacol. 2012 Aug 30;3:158. doi: 10.3389/fphar.2012.00158. eCollection 2012. Front Pharmacol. 2012. PMID: 22969722 Free PMC article.
These results show that telemetric assessment of the VMR is a sensitive tool, suitable for long-term studies in conscious rats. The results with this technique also suggest that ENDO-associated vaginal hyperalgesia involves COX activity, the feature that also underlies inf …
These results show that telemetric assessment of the VMR is a sensitive tool, suitable for long-term studies in conscious rats. The r …
Endpoints of drug discovery for menopausal vasomotor symptoms: interpretation of data from a proxy of disease.
Prelle K, Igl BW, Obendorf M, Girbig D, Lehmann T, Patchev VK. Prelle K, et al. Among authors: patchev vk. Menopause. 2012 Aug;19(8):909-15. doi: 10.1097/gme.0b013e318245533f. Menopause. 2012. PMID: 22473248
METHODS: Using telemetric recordings in a rat model of estrogen deficit-induced vasomotor dysregulation, we compared the long- and short-term effects of estrogen supplementation and treatment with neuropharmaceuticals (venlafaxine, desvenlafaxine, fluoxetine, agomelatine, …
METHODS: Using telemetric recordings in a rat model of estrogen deficit-induced vasomotor dysregulation, we compared the long- and short- …
Neuroendocrine and neurochemical consequences of long-term sleep deprivation in rats: similarities to some features of depression.
Patchev V, Felszeghy K, Korányi L. Patchev V, et al. Homeost Health Dis. 1991;33(3):97-108. Homeost Health Dis. 1991. PMID: 1818684
The paradigm of long-term sleep deprivation was used as a model of chronic inescapable stress in rats. ...Behavioural depression and altered open field activity were also observed in exhausted animals. Long-term sleep deprivation, therefore, seems to reproduce some …
The paradigm of long-term sleep deprivation was used as a model of chronic inescapable stress in rats. ...Behavioural depression and …
Adrenalectomy and experimental hypercorticalism modulate the basal, corticotropin-releasing-hormone- and arginine-vasopressin-stimulated release of hypothalamic beta-endorphin.
Patchev VK, Racké K, Almeida OF. Patchev VK, et al. Neuroendocrinology. 1991 Aug;54(2):111-7. doi: 10.1159/000125859. Neuroendocrinology. 1991. PMID: 1766548
However, whereas AVP merely synergizes with CRH in the pituitary, it seems to be essential for the release of hypothalamic beta-END by CRH. The present paper reports on the effects of long-term adrenalectomy (ADX) and subsequent replacement with supraphysiological doses of …
However, whereas AVP merely synergizes with CRH in the pituitary, it seems to be essential for the release of hypothalamic beta-END by CRH. …
Melatonin effects on glucocorticoid receptors in rat brain and pituitary: significance in adrenocortical regulation.
Marinova C, Persengiev S, Konakchieva R, Ilieva A, Patchev V. Marinova C, et al. Among authors: patchev v. Int J Biochem. 1991;23(4):479-81. doi: 10.1016/0020-711x(91)90177-o. Int J Biochem. 1991. PMID: 2015956
The effects of chronic melatonin treatment on glucocorticoid binding sites in hippocampus, hypothalamus and pituitary were investigated in rats, subjected to long-term manipulation of circulating corticosterone concentrations. 2. ...The effect of melatonin was apparent in …
The effects of chronic melatonin treatment on glucocorticoid binding sites in hippocampus, hypothalamus and pituitary were investigated in r …
Melatonin effects on thymus steroid receptors in the course of primary antibody responses: significance of circulating glucocorticoid levels.
Persengiev S, Patchev V, Velev B. Persengiev S, et al. Among authors: patchev v. Int J Biochem. 1991;23(12):1487-9. doi: 10.1016/0020-711x(91)90292-u. Int J Biochem. 1991. PMID: 1761156
The effects of chronic melatonin treatment on antibody production and thymus glucocorticoid and progestin binding sites in the course of primary immune response were investigated in rats subjected to long-term manipulations of circulating glucocorticoid concentrations. 2. …
The effects of chronic melatonin treatment on antibody production and thymus glucocorticoid and progestin binding sites in the course of pri …
Steroid hormone receptors in the thymus: a site of immunomodulatory action of melatonin.
Persengiev S, Marinova C, Patchev V. Persengiev S, et al. Among authors: patchev v. Int J Biochem. 1991;23(12):1483-5. doi: 10.1016/0020-711x(91)90291-t. Int J Biochem. 1991. PMID: 1761155
The probability for an interaction between these hormones in the thymus gland has been investigated in rats following chronic administration of exogenous melatonin and long-term exposure to variable levels of circulating glucocorticoids. 2. ...
The probability for an interaction between these hormones in the thymus gland has been investigated in rats following chronic administration …
Ovariectomy- and sex hormone-induced changes in the excitability of the CNS: an assessment by EEG paroxysmal activity and behaviour.
Nikiforova AS, Patchev VK, Nikolov ND. Nikiforova AS, et al. Among authors: patchev vk. Acta Physiol Pharmacol Bulg. 1989;15(4):48-52. Acta Physiol Pharmacol Bulg. 1989. PMID: 2634904
The experimental results showed that the removal of the sex hormone secretion for a long-term period causes a discrepancy between the decrease of behavioral patterns and increased excitability in CNS. ...
The experimental results showed that the removal of the sex hormone secretion for a long-term period causes a discrepancy between the …
Long-term locomotion regimens affect EEG paroxysmal activity, behaviour and sex hormone secretion in female rats.
Nikiforova AS, Patchev VK, Nikolov ND. Nikiforova AS, et al. Among authors: patchev vk. Acta Physiol Pharmacol Bulg. 1989;15(3):31-7. Acta Physiol Pharmacol Bulg. 1989. PMID: 2603738
The study deals with the changes of the excitability of CNS in the course of the ovarial cycle under the influence of long-term locomotion regimens. The excitability of the CNS was evaluated by the spontaneous EEG paroxysmal activity and by the changes in certain behaviour …
The study deals with the changes of the excitability of CNS in the course of the ovarial cycle under the influence of long-term locom …
Spontaneous EEG paroxysmal activity, behavioural and endocrine changes in male rats subjected to different regimens of locomotion.
Nikiforova AS, Patchev VK, Nikolov ND. Nikiforova AS, et al. Among authors: patchev vk. Acta Physiol Pharmacol Bulg. 1989;15(2):58-62. Acta Physiol Pharmacol Bulg. 1989. PMID: 2552747
The changes in the excitability of the GNS of male rats were investigated following the influence of long-term (6 months) regimens of locomotion: running exercise and relative immobilization. ...Long-term restriction of the locomotion leads to an increase of the sen …
The changes in the excitability of the GNS of male rats were investigated following the influence of long-term (6 months) regimens of …